Relationship of plasma MBP and 8-oxo-dG with brain damage in preterm
Preterm infants face a significant risk of brain injury in the perinatal period, as well as potential long-term neurodevelopmental disabilities. However, preterm children with brain injury lack specific clinical manifestations in the early days. Therefore, timely and accurate diagnosis of brain inju...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2022-10-01
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| Series: | Open Medicine |
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| Online Access: | https://doi.org/10.1515/med-2022-0566 |
| _version_ | 1811324196493459456 |
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| author | Zhao Yuwei Liu Guanghui Liang Lei Yu Zaiwei Zhang Jian Zheng Hong Dai Liying |
| author_facet | Zhao Yuwei Liu Guanghui Liang Lei Yu Zaiwei Zhang Jian Zheng Hong Dai Liying |
| author_sort | Zhao Yuwei |
| collection | DOAJ |
| description | Preterm infants face a significant risk of brain injury in the perinatal period, as well as potential long-term neurodevelopmental disabilities. However, preterm children with brain injury lack specific clinical manifestations in the early days. Therefore, timely and accurate diagnosis of brain injury is of vital importance. This study was to explore the diagnostic efficiency of myelin basic protein (MBP) and 8-oxo-deoxyguanosine (8-oxo-dG) serum levels in brain injury of premature infants. A total of 75 preterm infants with gestational age between 28 and 32 weeks and birth weight higher than 1,000 g were prospectively included. MBP serum levels were significantly higher in premature infants with white matter injury (WMI). 8-oxo-dG serum levels were significantly increased in both WMI and periventricular–intraventricular hemorrhages (PIVH). MBP and 8-oxo-dG were significantly correlated. The area under the curve was 0.811 [95% confidence interval (CI) 0.667–0.955; p = 0.002] in MBP and 0.729 (95% CI 0.562–0.897; p = 0.020) in 8-oxo-dG. Therefore, the results showed that high MBP levels indicated a possibility of WMI in the premature brain during the early postnatal period, while high 8-oxo-dG levels were closely related to both WMI and PIVH, thus suggesting that MBP and 8-oxo-dG could be used as potential neuro-markers of preterm brain injury. |
| first_indexed | 2024-04-13T14:09:59Z |
| format | Article |
| id | doaj.art-9f0a60d78bdc4c3c9050a4d09d54321a |
| institution | Directory Open Access Journal |
| issn | 2391-5463 |
| language | English |
| last_indexed | 2024-04-13T14:09:59Z |
| publishDate | 2022-10-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Medicine |
| spelling | doaj.art-9f0a60d78bdc4c3c9050a4d09d54321a2022-12-22T02:43:48ZengDe GruyterOpen Medicine2391-54632022-10-011711674168110.1515/med-2022-0566Relationship of plasma MBP and 8-oxo-dG with brain damage in pretermZhao Yuwei0Liu Guanghui1Liang Lei2Yu Zaiwei3Zhang Jian4Zheng Hong5Dai Liying6Neonatology Department, Anhui Provincial Children Hospital, Hefei, ChinaNeonatology Department, Anhui Provincial Children Hospital, Hefei, ChinaPulmonary Department, Anhui Provincial Children Hospital, Hefei, ChinaNeonatology Department, Fuyang First People’s Hospital, Fuyang, ChinaNeonatology Department, Anhui Provincial Children Hospital, Hefei, ChinaNeonatology Department, Anhui Provincial Children Hospital, Hefei, ChinaNeonatology Department, Anhui Provincial Children Hospital, Hefei, ChinaPreterm infants face a significant risk of brain injury in the perinatal period, as well as potential long-term neurodevelopmental disabilities. However, preterm children with brain injury lack specific clinical manifestations in the early days. Therefore, timely and accurate diagnosis of brain injury is of vital importance. This study was to explore the diagnostic efficiency of myelin basic protein (MBP) and 8-oxo-deoxyguanosine (8-oxo-dG) serum levels in brain injury of premature infants. A total of 75 preterm infants with gestational age between 28 and 32 weeks and birth weight higher than 1,000 g were prospectively included. MBP serum levels were significantly higher in premature infants with white matter injury (WMI). 8-oxo-dG serum levels were significantly increased in both WMI and periventricular–intraventricular hemorrhages (PIVH). MBP and 8-oxo-dG were significantly correlated. The area under the curve was 0.811 [95% confidence interval (CI) 0.667–0.955; p = 0.002] in MBP and 0.729 (95% CI 0.562–0.897; p = 0.020) in 8-oxo-dG. Therefore, the results showed that high MBP levels indicated a possibility of WMI in the premature brain during the early postnatal period, while high 8-oxo-dG levels were closely related to both WMI and PIVH, thus suggesting that MBP and 8-oxo-dG could be used as potential neuro-markers of preterm brain injury.https://doi.org/10.1515/med-2022-0566myelin basic protein8-oxo-deoxyguanosinepreterm infantswhite matter injuryperiventricular–intraventricular hemorrhagesbrain injury |
| spellingShingle | Zhao Yuwei Liu Guanghui Liang Lei Yu Zaiwei Zhang Jian Zheng Hong Dai Liying Relationship of plasma MBP and 8-oxo-dG with brain damage in preterm Open Medicine myelin basic protein 8-oxo-deoxyguanosine preterm infants white matter injury periventricular–intraventricular hemorrhages brain injury |
| title | Relationship of plasma MBP and 8-oxo-dG with brain damage in preterm |
| title_full | Relationship of plasma MBP and 8-oxo-dG with brain damage in preterm |
| title_fullStr | Relationship of plasma MBP and 8-oxo-dG with brain damage in preterm |
| title_full_unstemmed | Relationship of plasma MBP and 8-oxo-dG with brain damage in preterm |
| title_short | Relationship of plasma MBP and 8-oxo-dG with brain damage in preterm |
| title_sort | relationship of plasma mbp and 8 oxo dg with brain damage in preterm |
| topic | myelin basic protein 8-oxo-deoxyguanosine preterm infants white matter injury periventricular–intraventricular hemorrhages brain injury |
| url | https://doi.org/10.1515/med-2022-0566 |
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