Genetic regulation of newborn telomere length is mediated and modified by DNA methylation

Genetic regulation of newborn telomere length is mediated and modified by DNA methylation

Telomere length at birth determines later life telomere length and potentially predicts ageing-related diseases. However, the genetic and epigenetic settings of telomere length in newborns have not been analyzed. In addition, no study yet has reported how the interplay between genetic variants and g...

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Bibliographic Details
Main Authors: Congrong Wang, Rossella Alfano, Brigitte Reimann, Janneke Hogervorst, Mariona Bustamante, Immaculata De Vivo, Michelle Plusquin, Tim S. Nawrot, Dries S. Martens
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Genetics
Subjects:
newborn
telomere
ageing
genetic variants
DNA methylation
mQTL
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.934277/full

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