Prenatal Pollutant Exposures and Hypothalamic Development: Early Life Disruption of Metabolic Programming
Environmental contaminants in ambient air pollution pose a serious risk to long-term metabolic health. Strong evidence shows that prenatal exposure to pollutants can significantly increase the risk of Type II Diabetes (T2DM) in children and all ethnicities, even without the prevalence of obesity. Th...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.938094/full |
| _version_ | 1811296702517215232 |
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| author | Lisa Koshko Sydney Scofield Gil Mor Marianna Sadagurski |
| author_facet | Lisa Koshko Sydney Scofield Gil Mor Marianna Sadagurski |
| author_sort | Lisa Koshko |
| collection | DOAJ |
| description | Environmental contaminants in ambient air pollution pose a serious risk to long-term metabolic health. Strong evidence shows that prenatal exposure to pollutants can significantly increase the risk of Type II Diabetes (T2DM) in children and all ethnicities, even without the prevalence of obesity. The central nervous system (CNS) is critical in regulating whole-body metabolism. Within the CNS, the hypothalamus lies at the intersection of the neuroendocrine and autonomic systems and is primarily responsible for the regulation of energy homeostasis and satiety signals. The hypothalamus is particularly sensitive to insults during early neurodevelopmental periods and may be susceptible to alterations in the formation of neural metabolic circuitry. Although the precise molecular mechanism is not yet defined, alterations in hypothalamic developmental circuits may represent a leading cause of impaired metabolic programming. In this review, we present the current knowledge on the links between prenatal pollutant exposure and the hypothalamic programming of metabolism. |
| first_indexed | 2024-04-13T05:52:23Z |
| format | Article |
| id | doaj.art-9f1015e2707548a3b3cbc205849e8a1c |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-13T05:52:23Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-9f1015e2707548a3b3cbc205849e8a1c2022-12-22T02:59:43ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-07-011310.3389/fendo.2022.938094938094Prenatal Pollutant Exposures and Hypothalamic Development: Early Life Disruption of Metabolic ProgrammingLisa Koshko0Sydney Scofield1Gil Mor2Marianna Sadagurski3Integrative Biosciences Center, Department of Biological Sciences, Wayne State University, Detroit, MI, United StatesIntegrative Biosciences Center, Department of Biological Sciences, Wayne State University, Detroit, MI, United StatesC.S. Mott Center for Human Growth and Development, Department of Obstetrics and Gynecology School of Medicine, Wayne State University, Detroit, MI, United StatesIntegrative Biosciences Center, Department of Biological Sciences, Wayne State University, Detroit, MI, United StatesEnvironmental contaminants in ambient air pollution pose a serious risk to long-term metabolic health. Strong evidence shows that prenatal exposure to pollutants can significantly increase the risk of Type II Diabetes (T2DM) in children and all ethnicities, even without the prevalence of obesity. The central nervous system (CNS) is critical in regulating whole-body metabolism. Within the CNS, the hypothalamus lies at the intersection of the neuroendocrine and autonomic systems and is primarily responsible for the regulation of energy homeostasis and satiety signals. The hypothalamus is particularly sensitive to insults during early neurodevelopmental periods and may be susceptible to alterations in the formation of neural metabolic circuitry. Although the precise molecular mechanism is not yet defined, alterations in hypothalamic developmental circuits may represent a leading cause of impaired metabolic programming. In this review, we present the current knowledge on the links between prenatal pollutant exposure and the hypothalamic programming of metabolism.https://www.frontiersin.org/articles/10.3389/fendo.2022.938094/fullprenatal environmental exposuresair pollutionhypothalamic developmentneuroinflammationmetabolic programmingmetabolic syndrome |
| spellingShingle | Lisa Koshko Sydney Scofield Gil Mor Marianna Sadagurski Prenatal Pollutant Exposures and Hypothalamic Development: Early Life Disruption of Metabolic Programming Frontiers in Endocrinology prenatal environmental exposures air pollution hypothalamic development neuroinflammation metabolic programming metabolic syndrome |
| title | Prenatal Pollutant Exposures and Hypothalamic Development: Early Life Disruption of Metabolic Programming |
| title_full | Prenatal Pollutant Exposures and Hypothalamic Development: Early Life Disruption of Metabolic Programming |
| title_fullStr | Prenatal Pollutant Exposures and Hypothalamic Development: Early Life Disruption of Metabolic Programming |
| title_full_unstemmed | Prenatal Pollutant Exposures and Hypothalamic Development: Early Life Disruption of Metabolic Programming |
| title_short | Prenatal Pollutant Exposures and Hypothalamic Development: Early Life Disruption of Metabolic Programming |
| title_sort | prenatal pollutant exposures and hypothalamic development early life disruption of metabolic programming |
| topic | prenatal environmental exposures air pollution hypothalamic development neuroinflammation metabolic programming metabolic syndrome |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.938094/full |
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