Childhood atopic diseases and early life circumstances: an ecological study in Cuba.
BACKGROUND: Children are especially vulnerable during periods of resource shortage such as economic embargoes. They are likely to suffer most from poor nutrition, infectious diseases, and other ensuing short-term threats. Moreover, early life circumstances can have important consequences for long-te...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3387214?pdf=render |
| _version_ | 1819276901157437440 |
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| author | Suzanne D van der Werff Katja Polman Maiza Campos Ponce Jos W R Twisk Raquel Junco Díaz Mariano Bonet Gorbea Patrick Van der Stuyft |
| author_facet | Suzanne D van der Werff Katja Polman Maiza Campos Ponce Jos W R Twisk Raquel Junco Díaz Mariano Bonet Gorbea Patrick Van der Stuyft |
| author_sort | Suzanne D van der Werff |
| collection | DOAJ |
| description | BACKGROUND: Children are especially vulnerable during periods of resource shortage such as economic embargoes. They are likely to suffer most from poor nutrition, infectious diseases, and other ensuing short-term threats. Moreover, early life circumstances can have important consequences for long-term health. We examined the relationship between early childhood exposure to the Cuban economic situation in the nineties and the occurrence of atopic diseases later in childhood. METHODOLOGY/PRINCIPAL FINDINGS: A cross-sectional study of 1321 primary schoolchildren aged 4-14 was conducted in two Cuban municipalities. Asthma, allergic rhinoconjunctivitis and atopic dermatitis were diagnosed using the International Study of Asthma and Allergies in Childhood questionnaire. Children were divided into three groups of exposure to the economic situation in the nineties according to birth date: (1) unexposed; (2) exposed during infancy; (3) exposed during infancy and early childhood. Associations were assessed using multiple logistic regression models. Exposure during infancy had a significant inverse association with the occurrence of asthma (OR 0.56, 95%CI 0.33-0.94) and allergic rhinoconjunctivitis (OR 0.46, 95%CI 0.25-0.85). The associations were stronger after longer exposure, i.e. during infancy and early childhood, for asthma (OR 0.40, 95% CI 0.17-0.95) and allergic rhinoconjunctivitis (OR 0.29, 95%CI 0.11-0.77). No significant associations were found for atopic dermatitis. CONCLUSIONS/SIGNIFICANCE: Exposure to the economic situation in the nineties during infancy and early childhood was inversely associated with asthma and allergic rhinoconjunctivitis occurrence later in childhood. We hypothesize that factors related to this period, such as infectious diseases and undernutrition, may have an attenuating effect on atopic disease development. The exact cause and underlying mechanisms need to be further elucidated. |
| first_indexed | 2024-12-23T23:47:35Z |
| format | Article |
| id | doaj.art-9f10a9b2dc6a4d48a4b4643751282d01 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-23T23:47:35Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-9f10a9b2dc6a4d48a4b4643751282d012022-12-21T17:25:29ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0176e3989210.1371/journal.pone.0039892Childhood atopic diseases and early life circumstances: an ecological study in Cuba.Suzanne D van der WerffKatja PolmanMaiza Campos PonceJos W R TwiskRaquel Junco DíazMariano Bonet GorbeaPatrick Van der StuyftBACKGROUND: Children are especially vulnerable during periods of resource shortage such as economic embargoes. They are likely to suffer most from poor nutrition, infectious diseases, and other ensuing short-term threats. Moreover, early life circumstances can have important consequences for long-term health. We examined the relationship between early childhood exposure to the Cuban economic situation in the nineties and the occurrence of atopic diseases later in childhood. METHODOLOGY/PRINCIPAL FINDINGS: A cross-sectional study of 1321 primary schoolchildren aged 4-14 was conducted in two Cuban municipalities. Asthma, allergic rhinoconjunctivitis and atopic dermatitis were diagnosed using the International Study of Asthma and Allergies in Childhood questionnaire. Children were divided into three groups of exposure to the economic situation in the nineties according to birth date: (1) unexposed; (2) exposed during infancy; (3) exposed during infancy and early childhood. Associations were assessed using multiple logistic regression models. Exposure during infancy had a significant inverse association with the occurrence of asthma (OR 0.56, 95%CI 0.33-0.94) and allergic rhinoconjunctivitis (OR 0.46, 95%CI 0.25-0.85). The associations were stronger after longer exposure, i.e. during infancy and early childhood, for asthma (OR 0.40, 95% CI 0.17-0.95) and allergic rhinoconjunctivitis (OR 0.29, 95%CI 0.11-0.77). No significant associations were found for atopic dermatitis. CONCLUSIONS/SIGNIFICANCE: Exposure to the economic situation in the nineties during infancy and early childhood was inversely associated with asthma and allergic rhinoconjunctivitis occurrence later in childhood. We hypothesize that factors related to this period, such as infectious diseases and undernutrition, may have an attenuating effect on atopic disease development. The exact cause and underlying mechanisms need to be further elucidated.http://europepmc.org/articles/PMC3387214?pdf=render |
| spellingShingle | Suzanne D van der Werff Katja Polman Maiza Campos Ponce Jos W R Twisk Raquel Junco Díaz Mariano Bonet Gorbea Patrick Van der Stuyft Childhood atopic diseases and early life circumstances: an ecological study in Cuba. PLoS ONE |
| title | Childhood atopic diseases and early life circumstances: an ecological study in Cuba. |
| title_full | Childhood atopic diseases and early life circumstances: an ecological study in Cuba. |
| title_fullStr | Childhood atopic diseases and early life circumstances: an ecological study in Cuba. |
| title_full_unstemmed | Childhood atopic diseases and early life circumstances: an ecological study in Cuba. |
| title_short | Childhood atopic diseases and early life circumstances: an ecological study in Cuba. |
| title_sort | childhood atopic diseases and early life circumstances an ecological study in cuba |
| url | http://europepmc.org/articles/PMC3387214?pdf=render |
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