Genomewide expression analysis in zebrafish mind bomb alleles with pancreas defects of different severity identifies putative Notch responsive genes.

Genomewide expression analysis in zebrafish mind bomb alleles with pancreas defects of different severity identifies putative Notch responsive genes.

BACKGROUND:Notch signaling is an evolutionarily conserved developmental pathway. Zebrafish mind bomb (mib) mutants carry mutations on mib gene, which encodes a RING E3 ligase required for Notch activation via Delta/Jagged ubiquitylation and internalization. METHODOLOGY/PRINCIPAL FINDINGS:We examined...

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Main Authors: Ashok Hegde, Nick Chuanxin Qiu, Xuehui Qiu, Steven Hao-Kee Ho, Kenny Qi-Ye Tay, Joshy George, Felicia Soo Lee Ng, Kunde Ramamoorthy Govindarajan, Zhiyuan Gong, Sinnakaruppan Mathavan, Yun-Jin Jiang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2195453?pdf=render

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