The Immunomodulatory Function of Vitamin D, with Particular Reference to SARS-CoV-2
Vaccines are the only way to reduce the morbidity associated to SARS-CoV-2 infection. The appearance of new mutations urges us to increase the effectiveness of vaccines as a complementary alternative. In this context, the use of adjuvant strategies has improved the effectiveness of different vaccine...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/57/12/1321 |
| _version_ | 1827671243486134272 |
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| author | Alberto Caballero-García David C. Noriega Hugo J. Bello Enrique Roche Alfredo Córdova-Martínez |
| author_facet | Alberto Caballero-García David C. Noriega Hugo J. Bello Enrique Roche Alfredo Córdova-Martínez |
| author_sort | Alberto Caballero-García |
| collection | DOAJ |
| description | Vaccines are the only way to reduce the morbidity associated to SARS-CoV-2 infection. The appearance of new mutations urges us to increase the effectiveness of vaccines as a complementary alternative. In this context, the use of adjuvant strategies has improved the effectiveness of different vaccines against virus infections such as dengue, influenza, and common cold. Recent reports on patients infected by COVID-19 reveal that low levels of circulating vitamin D correlate with a severe respiratory insufficiency. The immunomodulatory activity of this micronutrient attenuates the synthesis of pro-inflammatory cytokines and at the same time, increases antibody production. Therefore, the present review proposes the use of vitamin D as adjuvant micronutrient to increase the efficacy of vaccines against SARS-CoV-2 infection. |
| first_indexed | 2024-03-10T03:37:23Z |
| format | Article |
| id | doaj.art-9f116067f67544a8bc2fd37cb0e534f1 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-10T03:37:23Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-9f116067f67544a8bc2fd37cb0e534f12023-11-23T09:28:21ZengMDPI AGMedicina1010-660X1648-91442021-12-015712132110.3390/medicina57121321The Immunomodulatory Function of Vitamin D, with Particular Reference to SARS-CoV-2Alberto Caballero-García0David C. Noriega1Hugo J. Bello2Enrique Roche3Alfredo Córdova-Martínez4Department of Anatomy and Radiology, Health Sciences Faculty, GIR of Physical Exercise and Aging, Campus Universitario “Los Pajaritos”, 42004 Soria, SpainSpine Department, Valladolid University Hospital, University of Valladolid, 47005 Valladolid, SpainDepartment of Mathematics, School of Forestry Industry and Agronomic Engineering and Bioenergy, GIR of Physical Exercise and Aging, Campus Universitario “Los Pajaritos”, 42004 Soria, SpainDepartment of Applied Biology-Nutrition, Institute of Bioengineering, University Miguel Hernández, 03202 Elche, SpainDepartment of Biochemistry, Molecular Biology and Physiology, Faculty of Health Sciences, GIR of Physical Exercise and Aging, Campus Universitario “Los Pajaritos”, Valladolid University, 42004 Soria, SpainVaccines are the only way to reduce the morbidity associated to SARS-CoV-2 infection. The appearance of new mutations urges us to increase the effectiveness of vaccines as a complementary alternative. In this context, the use of adjuvant strategies has improved the effectiveness of different vaccines against virus infections such as dengue, influenza, and common cold. Recent reports on patients infected by COVID-19 reveal that low levels of circulating vitamin D correlate with a severe respiratory insufficiency. The immunomodulatory activity of this micronutrient attenuates the synthesis of pro-inflammatory cytokines and at the same time, increases antibody production. Therefore, the present review proposes the use of vitamin D as adjuvant micronutrient to increase the efficacy of vaccines against SARS-CoV-2 infection.https://www.mdpi.com/1648-9144/57/12/1321immunomodulationvaccinationvitamin D |
| spellingShingle | Alberto Caballero-García David C. Noriega Hugo J. Bello Enrique Roche Alfredo Córdova-Martínez The Immunomodulatory Function of Vitamin D, with Particular Reference to SARS-CoV-2 Medicina immunomodulation vaccination vitamin D |
| title | The Immunomodulatory Function of Vitamin D, with Particular Reference to SARS-CoV-2 |
| title_full | The Immunomodulatory Function of Vitamin D, with Particular Reference to SARS-CoV-2 |
| title_fullStr | The Immunomodulatory Function of Vitamin D, with Particular Reference to SARS-CoV-2 |
| title_full_unstemmed | The Immunomodulatory Function of Vitamin D, with Particular Reference to SARS-CoV-2 |
| title_short | The Immunomodulatory Function of Vitamin D, with Particular Reference to SARS-CoV-2 |
| title_sort | immunomodulatory function of vitamin d with particular reference to sars cov 2 |
| topic | immunomodulation vaccination vitamin D |
| url | https://www.mdpi.com/1648-9144/57/12/1321 |
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