In silico Approaches for the Design and Optimization of Interfering Peptides Against Protein–Protein Interactions

In silico Approaches for the Design and Optimization of Interfering Peptides Against Protein–Protein Interactions

Large contact surfaces of protein–protein interactions (PPIs) remain to be an ongoing issue in the discovery and design of small molecule modulators. Peptides are intrinsically capable of exploring larger surfaces, stable, and bioavailable, and therefore bear a high therapeutic value in the treatmen...

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Bibliographic Details
Main Authors: Zahra Sadat Hashemi, Mahboubeh Zarei, Mohsen Karami Fath, Mahmoud Ganji, Mahboube Shahrabi Farahani, Fatemeh Afsharnouri, Navid Pourzardosht, Bahman Khalesi, Abolfazl Jahangiri, Mohammad Reza Rahbar, Saeed Khalili
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Molecular Biosciences
Subjects:
peptide
protein–protein interactions
in silico
bioinformatics 3
interfering peptides
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.669431/full

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