Postprandial effects on plasma lipids and satiety hormones from intake of liposomes made from fractionated oat oil: two randomized crossover studies
Background: The composition and surface structure of dietary lipids influence their intestinal degradation. Intake of liposomes made of fractionated oat oil (LOO) is suggested to affect the digestion process and postprandial lipemia and also induce satiety. Objective: In the present study, the metab...
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| Format: | Article |
| Language: | English |
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Swedish Nutrition Foundation
2014-10-01
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| Series: | Food & Nutrition Research |
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| Online Access: | http://www.foodandnutritionresearch.net/index.php/fnr/article/download/24465/36156 |
| _version_ | 1811340553260892160 |
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| author | Lena Ohlsson Anna Rosenquist Jens F. Rehfeld Magnus Härröd |
| author_facet | Lena Ohlsson Anna Rosenquist Jens F. Rehfeld Magnus Härröd |
| author_sort | Lena Ohlsson |
| collection | DOAJ |
| description | Background: The composition and surface structure of dietary lipids influence their intestinal degradation. Intake of liposomes made of fractionated oat oil (LOO) is suggested to affect the digestion process and postprandial lipemia and also induce satiety. Objective: In the present study, the metabolic effects on plasma lipids and gut hormones related to satiety were investigated in healthy individuals after intake of LOO, with dairy lipids as placebo. Design: Two blinded randomized studies with crossover design were performed. In the first study, 19 subjects consumed 35 g lipids from LOO or yoghurt in a breakfast meal. In a follow-up study, 15 women consumed 14 or 1.8 g lipids from LOO mixed in yoghurt. Blood samples were analyzed for plasma lipids, insulin, glucose, and intestinal hormones CCK, PYY, GLP-1, and GLP-2 before and four times after the meal. Subjective analysis of satiety was measured using a visual analog scale questionnaire. Participants recorded their food intake during the rest of the day. Results: Intake of 35 and 14 g lipids from LOO significantly increased plasma concentrations of CCK, GLP-1, GLP-2, and PYY postprandially. This coincided with a prolonged elevation of triglycerides and large cholesterol-containing particles. Non-esterified fatty acids decreased after intake of 14 and 1.8 g lipids from LOO. The subjective sensation of satiety in women was increased 7 h after intake of 35 g lipids from LOO without any difference in food intake. Our results indicate that intake of 14 g lipids from LOO at breakfast substantially reduced energy intake during the rest of the day. Conclusions: This study suggests that intake of LOO prolong lipid digestion, affect postprandial plasma lipids and have an effect on satiety. The effect of LOO on GLP-2 indicates that intake of LOO also improve gut health. |
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| issn | 1654-661X |
| language | English |
| last_indexed | 2024-04-13T18:43:41Z |
| publishDate | 2014-10-01 |
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| spelling | doaj.art-9f13b7399c0c4d45a1625f0580dd530a2022-12-22T02:34:39ZengSwedish Nutrition FoundationFood & Nutrition Research1654-661X2014-10-0158011110.3402/fnr.v58.2446524465Postprandial effects on plasma lipids and satiety hormones from intake of liposomes made from fractionated oat oil: two randomized crossover studiesLena Ohlsson0Anna Rosenquist1Jens F. Rehfeld2Magnus Härröd3 Department of Clinical Science, Section of Medicine, University of Lund, Sweden Department of Clinical Science, Section of Medicine, University of Lund, Sweden Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark Härröd Research, Göteborg, SwedenBackground: The composition and surface structure of dietary lipids influence their intestinal degradation. Intake of liposomes made of fractionated oat oil (LOO) is suggested to affect the digestion process and postprandial lipemia and also induce satiety. Objective: In the present study, the metabolic effects on plasma lipids and gut hormones related to satiety were investigated in healthy individuals after intake of LOO, with dairy lipids as placebo. Design: Two blinded randomized studies with crossover design were performed. In the first study, 19 subjects consumed 35 g lipids from LOO or yoghurt in a breakfast meal. In a follow-up study, 15 women consumed 14 or 1.8 g lipids from LOO mixed in yoghurt. Blood samples were analyzed for plasma lipids, insulin, glucose, and intestinal hormones CCK, PYY, GLP-1, and GLP-2 before and four times after the meal. Subjective analysis of satiety was measured using a visual analog scale questionnaire. Participants recorded their food intake during the rest of the day. Results: Intake of 35 and 14 g lipids from LOO significantly increased plasma concentrations of CCK, GLP-1, GLP-2, and PYY postprandially. This coincided with a prolonged elevation of triglycerides and large cholesterol-containing particles. Non-esterified fatty acids decreased after intake of 14 and 1.8 g lipids from LOO. The subjective sensation of satiety in women was increased 7 h after intake of 35 g lipids from LOO without any difference in food intake. Our results indicate that intake of 14 g lipids from LOO at breakfast substantially reduced energy intake during the rest of the day. Conclusions: This study suggests that intake of LOO prolong lipid digestion, affect postprandial plasma lipids and have an effect on satiety. The effect of LOO on GLP-2 indicates that intake of LOO also improve gut health.http://www.foodandnutritionresearch.net/index.php/fnr/article/download/24465/36156polar lipidsliposomespostprandial lipemiaintestinal hormonessatietygut health |
| spellingShingle | Lena Ohlsson Anna Rosenquist Jens F. Rehfeld Magnus Härröd Postprandial effects on plasma lipids and satiety hormones from intake of liposomes made from fractionated oat oil: two randomized crossover studies Food & Nutrition Research polar lipids liposomes postprandial lipemia intestinal hormones satiety gut health |
| title | Postprandial effects on plasma lipids and satiety hormones from intake of liposomes made from fractionated oat oil: two randomized crossover studies |
| title_full | Postprandial effects on plasma lipids and satiety hormones from intake of liposomes made from fractionated oat oil: two randomized crossover studies |
| title_fullStr | Postprandial effects on plasma lipids and satiety hormones from intake of liposomes made from fractionated oat oil: two randomized crossover studies |
| title_full_unstemmed | Postprandial effects on plasma lipids and satiety hormones from intake of liposomes made from fractionated oat oil: two randomized crossover studies |
| title_short | Postprandial effects on plasma lipids and satiety hormones from intake of liposomes made from fractionated oat oil: two randomized crossover studies |
| title_sort | postprandial effects on plasma lipids and satiety hormones from intake of liposomes made from fractionated oat oil two randomized crossover studies |
| topic | polar lipids liposomes postprandial lipemia intestinal hormones satiety gut health |
| url | http://www.foodandnutritionresearch.net/index.php/fnr/article/download/24465/36156 |
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