Evaluation of the Cytotoxic Effects of Ultrasonic Extracts of Tribulus Terrestris L. on MCF-7 Cell Line by MTT Assay
People, especially those living in rural environments and those who have recently been dissatisfied with traditional medicine, use medicinal plants for their therapeutic effects. In this study, ethanol, ethyl acetate and methanol extracts of Tribulus terrestris L. plant, which is used by local peopl...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Hitit University
2021-12-01
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| Series: | Hittite Journal of Science and Engineering |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/tr/download/article-file/1884845 |
| _version_ | 1797662661410816000 |
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| author | Füreya Elif Öztürkkan Giray Buğra Akbaba Mustafa Sertçelik |
| author_facet | Füreya Elif Öztürkkan Giray Buğra Akbaba Mustafa Sertçelik |
| author_sort | Füreya Elif Öztürkkan |
| collection | DOAJ |
| description | People, especially those living in rural environments and those who have recently been dissatisfied with traditional medicine, use medicinal plants for their therapeutic effects. In this study, ethanol, ethyl acetate and methanol extracts of Tribulus terrestris L. plant, which is used by local people as one of these medicinal plants in Kars province (Turkey), were obtained by ultrasound assisted extraction method. The cytotoxic effects of the obtained extracts on MCF-7 breast cancer cells in the concentration range of 10-1000 ppm at 24 h of exposure were investigated by the MTT method, which is a colorimetric method. T. terrestris L. ethanol extracts at 1000 ppm caused a moderate cytotoxic effect on MCF-7 breast cancer cells. It was determined that ethanolic extracts in the concentration range of 10-500 ppm and methanol and ethyl acetate extracts in the concentration of 10-1000 ppm caused cell proliferation. |
| first_indexed | 2024-03-11T19:03:34Z |
| format | Article |
| id | doaj.art-9f1406edff094504bcedd04f17e5ff73 |
| institution | Directory Open Access Journal |
| issn | 2148-4171 |
| language | English |
| last_indexed | 2024-03-11T19:03:34Z |
| publishDate | 2021-12-01 |
| publisher | Hitit University |
| record_format | Article |
| series | Hittite Journal of Science and Engineering |
| spelling | doaj.art-9f1406edff094504bcedd04f17e5ff732023-10-10T11:17:28ZengHitit UniversityHittite Journal of Science and Engineering2148-41712021-12-018430731210.17350/HJSE19030000243150Evaluation of the Cytotoxic Effects of Ultrasonic Extracts of Tribulus Terrestris L. on MCF-7 Cell Line by MTT AssayFüreya Elif Öztürkkan0Giray Buğra Akbaba1Mustafa Sertçelik2Kafkas ÜniversitesiKAFKAS ÜNİVERSİTESİKAFKAS ÜNİVERSİTESİPeople, especially those living in rural environments and those who have recently been dissatisfied with traditional medicine, use medicinal plants for their therapeutic effects. In this study, ethanol, ethyl acetate and methanol extracts of Tribulus terrestris L. plant, which is used by local people as one of these medicinal plants in Kars province (Turkey), were obtained by ultrasound assisted extraction method. The cytotoxic effects of the obtained extracts on MCF-7 breast cancer cells in the concentration range of 10-1000 ppm at 24 h of exposure were investigated by the MTT method, which is a colorimetric method. T. terrestris L. ethanol extracts at 1000 ppm caused a moderate cytotoxic effect on MCF-7 breast cancer cells. It was determined that ethanolic extracts in the concentration range of 10-500 ppm and methanol and ethyl acetate extracts in the concentration of 10-1000 ppm caused cell proliferation.https://dergipark.org.tr/tr/download/article-file/1884845tribulus terrestris l.mcf-7ultrasound assisted extractioncytotoxicitymtt assay |
| spellingShingle | Füreya Elif Öztürkkan Giray Buğra Akbaba Mustafa Sertçelik Evaluation of the Cytotoxic Effects of Ultrasonic Extracts of Tribulus Terrestris L. on MCF-7 Cell Line by MTT Assay Hittite Journal of Science and Engineering tribulus terrestris l. mcf-7 ultrasound assisted extraction cytotoxicity mtt assay |
| title | Evaluation of the Cytotoxic Effects of Ultrasonic Extracts of Tribulus Terrestris L. on MCF-7 Cell Line by MTT Assay |
| title_full | Evaluation of the Cytotoxic Effects of Ultrasonic Extracts of Tribulus Terrestris L. on MCF-7 Cell Line by MTT Assay |
| title_fullStr | Evaluation of the Cytotoxic Effects of Ultrasonic Extracts of Tribulus Terrestris L. on MCF-7 Cell Line by MTT Assay |
| title_full_unstemmed | Evaluation of the Cytotoxic Effects of Ultrasonic Extracts of Tribulus Terrestris L. on MCF-7 Cell Line by MTT Assay |
| title_short | Evaluation of the Cytotoxic Effects of Ultrasonic Extracts of Tribulus Terrestris L. on MCF-7 Cell Line by MTT Assay |
| title_sort | evaluation of the cytotoxic effects of ultrasonic extracts of tribulus terrestris l on mcf 7 cell line by mtt assay |
| topic | tribulus terrestris l. mcf-7 ultrasound assisted extraction cytotoxicity mtt assay |
| url | https://dergipark.org.tr/tr/download/article-file/1884845 |
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