Painful and non‐painful diabetic polyneuropathy: Clinical characteristics and diagnostic issues
Abstract Diabetic neuropathy (DN) is a common complication of diabetes and can be either painful or non‐painful. It is challenging to diagnose this complication, as no biomarker or clear consensus on the clinical definition of either painful or non‐painful DN exists. Hence, a hierarchical classifica...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-09-01
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| Series: | Journal of Diabetes Investigation |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jdi.13105 |
| _version_ | 1818865946954039296 |
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| author | Sandra Sif Gylfadottir Danita Weeracharoenkul Signe Toft Andersen Supranee Niruthisard Sompongse Suwanwalaikorn Troels Staehelin Jensen |
| author_facet | Sandra Sif Gylfadottir Danita Weeracharoenkul Signe Toft Andersen Supranee Niruthisard Sompongse Suwanwalaikorn Troels Staehelin Jensen |
| author_sort | Sandra Sif Gylfadottir |
| collection | DOAJ |
| description | Abstract Diabetic neuropathy (DN) is a common complication of diabetes and can be either painful or non‐painful. It is challenging to diagnose this complication, as no biomarker or clear consensus on the clinical definition of either painful or non‐painful DN exists. Hence, a hierarchical classification has been developed categorizing the probability of the diagnosis into: possible, probable or definite, based on the clinical presentation of symptoms and signs. Pain is a warning signal of tissue damage, and non‐painful DN therefore represents a clinical and diagnostic challenge because it often goes unnoticed until irreversible nerve damage has occurred. Simple clinical tests seem to be the best for evaluation of DN in the general care for diabetes. Screening programs at regular intervals might be the most optimal strategy for early detection and interventions to possibly prevent further neuronal damage and to lower the economic burden of this complication. |
| first_indexed | 2024-12-19T10:55:38Z |
| format | Article |
| id | doaj.art-9f156c1b779f4d67a3a1b2a2c3d8b2c2 |
| institution | Directory Open Access Journal |
| issn | 2040-1116 2040-1124 |
| language | English |
| last_indexed | 2024-12-19T10:55:38Z |
| publishDate | 2019-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Investigation |
| spelling | doaj.art-9f156c1b779f4d67a3a1b2a2c3d8b2c22022-12-21T20:24:49ZengWileyJournal of Diabetes Investigation2040-11162040-11242019-09-011051148115710.1111/jdi.13105Painful and non‐painful diabetic polyneuropathy: Clinical characteristics and diagnostic issuesSandra Sif Gylfadottir0Danita Weeracharoenkul1Signe Toft Andersen2Supranee Niruthisard3Sompongse Suwanwalaikorn4Troels Staehelin Jensen5Danish Pain Research Center Aarhus University Aarhus DenmarkPain Management Research Unit Department of Anesthesiology Faculty of Medicine King Chulalongkorn Memorial Hospital Chulalongkorn University Bangkok ThailandDanish Pain Research Center Aarhus University Aarhus DenmarkPain Management Research Unit Department of Anesthesiology Faculty of Medicine King Chulalongkorn Memorial Hospital Chulalongkorn University Bangkok ThailandDepartment of Medicine Faculty of Medicine King Chulalongkorn Memorial Hospital Chulalongkorn University Bangkok ThailandDanish Pain Research Center Aarhus University Aarhus DenmarkAbstract Diabetic neuropathy (DN) is a common complication of diabetes and can be either painful or non‐painful. It is challenging to diagnose this complication, as no biomarker or clear consensus on the clinical definition of either painful or non‐painful DN exists. Hence, a hierarchical classification has been developed categorizing the probability of the diagnosis into: possible, probable or definite, based on the clinical presentation of symptoms and signs. Pain is a warning signal of tissue damage, and non‐painful DN therefore represents a clinical and diagnostic challenge because it often goes unnoticed until irreversible nerve damage has occurred. Simple clinical tests seem to be the best for evaluation of DN in the general care for diabetes. Screening programs at regular intervals might be the most optimal strategy for early detection and interventions to possibly prevent further neuronal damage and to lower the economic burden of this complication.https://doi.org/10.1111/jdi.13105Clinical characteristicsDiabetic neuropathyDiagnosis |
| spellingShingle | Sandra Sif Gylfadottir Danita Weeracharoenkul Signe Toft Andersen Supranee Niruthisard Sompongse Suwanwalaikorn Troels Staehelin Jensen Painful and non‐painful diabetic polyneuropathy: Clinical characteristics and diagnostic issues Journal of Diabetes Investigation Clinical characteristics Diabetic neuropathy Diagnosis |
| title | Painful and non‐painful diabetic polyneuropathy: Clinical characteristics and diagnostic issues |
| title_full | Painful and non‐painful diabetic polyneuropathy: Clinical characteristics and diagnostic issues |
| title_fullStr | Painful and non‐painful diabetic polyneuropathy: Clinical characteristics and diagnostic issues |
| title_full_unstemmed | Painful and non‐painful diabetic polyneuropathy: Clinical characteristics and diagnostic issues |
| title_short | Painful and non‐painful diabetic polyneuropathy: Clinical characteristics and diagnostic issues |
| title_sort | painful and non painful diabetic polyneuropathy clinical characteristics and diagnostic issues |
| topic | Clinical characteristics Diabetic neuropathy Diagnosis |
| url | https://doi.org/10.1111/jdi.13105 |
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