Genealogy, Dendritic Cell Priming, and Differentiation of Tissue-Resident Memory CD8+ T Cells
Tissue-resident memory CD8+ T (Trm) cells define a distinct non-recirculating subset. Trm cells constitute a first line of defense against local infections in barrier tissues, but they are also found in non-barrier tissues and play a role in antitumor immunity. Their differentiation in tissues and t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-07-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2018.01751/full |
| _version_ | 1817999126883729408 |
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| author | Michel Enamorado Sofía C. Khouili Salvador Iborra David Sancho |
| author_facet | Michel Enamorado Sofía C. Khouili Salvador Iborra David Sancho |
| author_sort | Michel Enamorado |
| collection | DOAJ |
| description | Tissue-resident memory CD8+ T (Trm) cells define a distinct non-recirculating subset. Trm cells constitute a first line of defense against local infections in barrier tissues, but they are also found in non-barrier tissues and play a role in antitumor immunity. Their differentiation in tissues and their phenotypical, transcriptional, and functional characteristics are the object of active research. Herein, we will discuss the potential existence of committed CD8+ Trm precursors and the genealogy of memory CD8+ T cell subsets. In addition to the priming of naive T cells, there is some plasticity of antigen-experienced effector and memory T cell subsets to generate Trm precursors. Local inflammation, antigen presentation, and cytokines drive Trm differentiation. It is of prime interest how specific dendritic cell subsets modulate priming and differentiation of Trm cells, as well as their reactivation within tissues. Research on how we can manipulate generation of memory T cells subsets is key for improved vaccination strategies. |
| first_indexed | 2024-04-14T03:04:00Z |
| format | Article |
| id | doaj.art-9f1acf5cb4964f84ac35dd1114cf6bcb |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-14T03:04:00Z |
| publishDate | 2018-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-9f1acf5cb4964f84ac35dd1114cf6bcb2022-12-22T02:15:50ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-07-01910.3389/fimmu.2018.01751392784Genealogy, Dendritic Cell Priming, and Differentiation of Tissue-Resident Memory CD8+ T CellsMichel Enamorado0Sofía C. Khouili1Salvador Iborra2David Sancho3Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, SpainCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, SpainDepartment of Immunology, School of Medicine, Universidad Complutense de Madrid, 12 de Octubre Health Research Institute (imas12), Madrid, SpainCentro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, SpainTissue-resident memory CD8+ T (Trm) cells define a distinct non-recirculating subset. Trm cells constitute a first line of defense against local infections in barrier tissues, but they are also found in non-barrier tissues and play a role in antitumor immunity. Their differentiation in tissues and their phenotypical, transcriptional, and functional characteristics are the object of active research. Herein, we will discuss the potential existence of committed CD8+ Trm precursors and the genealogy of memory CD8+ T cell subsets. In addition to the priming of naive T cells, there is some plasticity of antigen-experienced effector and memory T cell subsets to generate Trm precursors. Local inflammation, antigen presentation, and cytokines drive Trm differentiation. It is of prime interest how specific dendritic cell subsets modulate priming and differentiation of Trm cells, as well as their reactivation within tissues. Research on how we can manipulate generation of memory T cells subsets is key for improved vaccination strategies.https://www.frontiersin.org/article/10.3389/fimmu.2018.01751/fullmemory CD8+ T cellcirculating memorytissue-resident memoryinfectionplasticitypriming |
| spellingShingle | Michel Enamorado Sofía C. Khouili Salvador Iborra David Sancho Genealogy, Dendritic Cell Priming, and Differentiation of Tissue-Resident Memory CD8+ T Cells Frontiers in Immunology memory CD8+ T cell circulating memory tissue-resident memory infection plasticity priming |
| title | Genealogy, Dendritic Cell Priming, and Differentiation of Tissue-Resident Memory CD8+ T Cells |
| title_full | Genealogy, Dendritic Cell Priming, and Differentiation of Tissue-Resident Memory CD8+ T Cells |
| title_fullStr | Genealogy, Dendritic Cell Priming, and Differentiation of Tissue-Resident Memory CD8+ T Cells |
| title_full_unstemmed | Genealogy, Dendritic Cell Priming, and Differentiation of Tissue-Resident Memory CD8+ T Cells |
| title_short | Genealogy, Dendritic Cell Priming, and Differentiation of Tissue-Resident Memory CD8+ T Cells |
| title_sort | genealogy dendritic cell priming and differentiation of tissue resident memory cd8 t cells |
| topic | memory CD8+ T cell circulating memory tissue-resident memory infection plasticity priming |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2018.01751/full |
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