Diabetic Peripheral Neuropathy Associated with Cardiovascular Risk Factors and Glucagon-Like Peptide-1 Concentrations Among Newly Diagnosed Patients with Type 2 Diabetes Mellitus
Tuan Dinh Le,1,2,* Nga Phi Thi Nguyen,2 Hoa Thanh Thi Tran,3 Thuc Luong Cong,4,* Lan Ho Thi Nguyen,5 Binh Do Nhu,6 Son Tien Nguyen,2 Manh Van Ngo,7 Hoa Trung Dinh,8 Hien Thi Nguyen,9 Kien Trung Nguyen,10 Duc-Cuong Le7,11,* 1Center of Emergency, Critical Care Medicine and Clin...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-01-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
| Subjects: | |
| Online Access: | https://www.dovepress.com/diabetic-peripheral-neuropathy-associated-with-cardiovascular-risk-fac-peer-reviewed-fulltext-article-DMSO |
| _version_ | 1797936700262973440 |
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| author | Dinh Le T Phi Thi Nguyen N Thanh Thi Tran H Luong Cong T Ho Thi Nguyen L Do Nhu B Tien Nguyen S Van Ngo M Trung Dinh H Thi Nguyen H Trung Nguyen K Duc-Cuong Le |
| author_facet | Dinh Le T Phi Thi Nguyen N Thanh Thi Tran H Luong Cong T Ho Thi Nguyen L Do Nhu B Tien Nguyen S Van Ngo M Trung Dinh H Thi Nguyen H Trung Nguyen K Duc-Cuong Le |
| author_sort | Dinh Le T |
| collection | DOAJ |
| description | Tuan Dinh Le,1,2,* Nga Phi Thi Nguyen,2 Hoa Thanh Thi Tran,3 Thuc Luong Cong,4,* Lan Ho Thi Nguyen,5 Binh Do Nhu,6 Son Tien Nguyen,2 Manh Van Ngo,7 Hoa Trung Dinh,8 Hien Thi Nguyen,9 Kien Trung Nguyen,10 Duc-Cuong Le7,11,* 1Center of Emergency, Critical Care Medicine and Clinical Toxicology, Military Hospital 103, Vietnam Military Medical University, Ha Noi, Vietnam; 2Department of Rheumatology and Endocrinology, Military Hospital 103, Vietnam Military Medical University, Ha Noi, Vietnam; 3National Hospital of Endocrinology, Hanoi, Vietnam; 4Department of Cardiology, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam; 5Department of General Internal Medicine, National Hospital of Endocrinology, Ha Noi, Vietnam; 6Division of Military Science, Military Hospital 103, Vietnam Military Medical University, Ha Noi, Vietnam; 7Postgraduate Training Management Department, Thai Binh University of Medicine and Pharmacy, Thai Binh, Vietnam; 8Department of Requested Treatment, National Hospital of Endocrinology, Ha Noi, Vietnam; 9Department of Physiology, Thai Binh University of Medicine and Pharmacy, Thai Binh, Vietnam; 10Department of Science Management, Thai Binh University of Medicine and Pharmacy, Thai Binh, Vietnam; 11Epidemiology-Faculty of Public Health, Thai Binh University of Medicine and Pharmacy, Thai Binh, Vietnam*These authors contributed equally to this workCorrespondence: Tuan Dinh LeCenter of Emergency, Critical Care Medicine and Clinical Toxicology, Department of Rheumatology and Endocrinology, Military Hospital 103, Vietnam Military Medical University, 261 Phung Hung Street, Phuc La Ward, Ha Dong District, Ha Noi, VietnamTel +840388166078Email letuan985@gmail.comDuc-Cuong LePostgraduate Training Management Department; Epidemiology-Faculty of Public Health, Thai Binh University of Medicine and Pharmacy, 373 Ly Bon Street, Ky Ba Ward, Thai Binh, VietnamTel +84 93 8042 668Email cuongldvn@gmail.comPurpose: This study was aimed at the prevalence, cardiovascular risk factors of diabetic peripheral neuropathy (DPN), and the relationship between DPN and fasting glucagon-like peptide-1 (fGLP-1) concentrations in newly diagnosed patients with type 2 diabetes mellitus (nT2D).Methods: A cross-sectional descriptive study was conducted from 2015 to 2020 with a population of 473 nT2D. Screening for DPN was based on the United Kingdom screening test. fGLP-1 was measured by enzyme-linked immunosorbent assay.Results: The prevalence of DPN was 26.6%, in which mild grade was 17.3%, moderate grade was 8.2% and severe grade was 1.1% in total. Age (OR = 1.73, 95% CI 1.12– 2.67, p = 0.012), smoking (OR = 1.64, 95% CI 1.03– 2.62, p = 0.037), poor control HbA1c (OR = 2.66, 95% CI 1.23– 5.76, p = 0.01), 24-h urinary albumin (24hUA) (OR = 2.49, 95% CI 1.26– 4.94, p = 0.007), and diabetic retinopathy (OR = 3.17, 95% CI 1.46– 6.89, p = 0.002) significantly increased the risk for DPN. In multivariate logistic regression analysis, hypertension (OR = 2.96, 95% CI 1.16– 7.55, p = 0.023), triglyceride (OR = 1.50, 95% CI 1.11– 2.03, p = 0.009), albumin (OR = 0.85, 95% CI 0.75– 0.95, p = 0.005), and fGLP-1 (OR = 0.79, 95% CI 0.67– 0.93, p = 0.005) correlated with DPN. The fGLP-1 concentrations were reduced significantly in DPN (p < 0.001). In particular, male patients with DPN had a significantly lower fGLP-1 levels than those without DPN (p < 0.001).Conclusion: The prevalence of DPN among nT2D was 26.6%. Age, smoking, hypertension, HbA1c control, triglyceride, albumin, 24hUA, diabetic retinopathy were the associated risk factors of DPN, and fGLP-1 was negatively correlated with DPN (OR = 0.79, 95% CI 0.67– 0.93, p = 0.005).Keywords: newly diagnosed type 2 diabetes mellitus, diabetic peripheral neuropathy, cardiovascular risk factors, glucagon-like peptide-1 concentrations |
| first_indexed | 2024-04-10T18:33:24Z |
| format | Article |
| id | doaj.art-9f1beb051735480983a4984e4eff4d58 |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-04-10T18:33:24Z |
| publishDate | 2022-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-9f1beb051735480983a4984e4eff4d582023-02-02T02:45:11ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072022-01-01Volume 15354472085Diabetic Peripheral Neuropathy Associated with Cardiovascular Risk Factors and Glucagon-Like Peptide-1 Concentrations Among Newly Diagnosed Patients with Type 2 Diabetes MellitusDinh Le TPhi Thi Nguyen NThanh Thi Tran HLuong Cong THo Thi Nguyen LDo Nhu BTien Nguyen SVan Ngo MTrung Dinh HThi Nguyen HTrung Nguyen KDuc-Cuong LeTuan Dinh Le,1,2,* Nga Phi Thi Nguyen,2 Hoa Thanh Thi Tran,3 Thuc Luong Cong,4,* Lan Ho Thi Nguyen,5 Binh Do Nhu,6 Son Tien Nguyen,2 Manh Van Ngo,7 Hoa Trung Dinh,8 Hien Thi Nguyen,9 Kien Trung Nguyen,10 Duc-Cuong Le7,11,* 1Center of Emergency, Critical Care Medicine and Clinical Toxicology, Military Hospital 103, Vietnam Military Medical University, Ha Noi, Vietnam; 2Department of Rheumatology and Endocrinology, Military Hospital 103, Vietnam Military Medical University, Ha Noi, Vietnam; 3National Hospital of Endocrinology, Hanoi, Vietnam; 4Department of Cardiology, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam; 5Department of General Internal Medicine, National Hospital of Endocrinology, Ha Noi, Vietnam; 6Division of Military Science, Military Hospital 103, Vietnam Military Medical University, Ha Noi, Vietnam; 7Postgraduate Training Management Department, Thai Binh University of Medicine and Pharmacy, Thai Binh, Vietnam; 8Department of Requested Treatment, National Hospital of Endocrinology, Ha Noi, Vietnam; 9Department of Physiology, Thai Binh University of Medicine and Pharmacy, Thai Binh, Vietnam; 10Department of Science Management, Thai Binh University of Medicine and Pharmacy, Thai Binh, Vietnam; 11Epidemiology-Faculty of Public Health, Thai Binh University of Medicine and Pharmacy, Thai Binh, Vietnam*These authors contributed equally to this workCorrespondence: Tuan Dinh LeCenter of Emergency, Critical Care Medicine and Clinical Toxicology, Department of Rheumatology and Endocrinology, Military Hospital 103, Vietnam Military Medical University, 261 Phung Hung Street, Phuc La Ward, Ha Dong District, Ha Noi, VietnamTel +840388166078Email letuan985@gmail.comDuc-Cuong LePostgraduate Training Management Department; Epidemiology-Faculty of Public Health, Thai Binh University of Medicine and Pharmacy, 373 Ly Bon Street, Ky Ba Ward, Thai Binh, VietnamTel +84 93 8042 668Email cuongldvn@gmail.comPurpose: This study was aimed at the prevalence, cardiovascular risk factors of diabetic peripheral neuropathy (DPN), and the relationship between DPN and fasting glucagon-like peptide-1 (fGLP-1) concentrations in newly diagnosed patients with type 2 diabetes mellitus (nT2D).Methods: A cross-sectional descriptive study was conducted from 2015 to 2020 with a population of 473 nT2D. Screening for DPN was based on the United Kingdom screening test. fGLP-1 was measured by enzyme-linked immunosorbent assay.Results: The prevalence of DPN was 26.6%, in which mild grade was 17.3%, moderate grade was 8.2% and severe grade was 1.1% in total. Age (OR = 1.73, 95% CI 1.12– 2.67, p = 0.012), smoking (OR = 1.64, 95% CI 1.03– 2.62, p = 0.037), poor control HbA1c (OR = 2.66, 95% CI 1.23– 5.76, p = 0.01), 24-h urinary albumin (24hUA) (OR = 2.49, 95% CI 1.26– 4.94, p = 0.007), and diabetic retinopathy (OR = 3.17, 95% CI 1.46– 6.89, p = 0.002) significantly increased the risk for DPN. In multivariate logistic regression analysis, hypertension (OR = 2.96, 95% CI 1.16– 7.55, p = 0.023), triglyceride (OR = 1.50, 95% CI 1.11– 2.03, p = 0.009), albumin (OR = 0.85, 95% CI 0.75– 0.95, p = 0.005), and fGLP-1 (OR = 0.79, 95% CI 0.67– 0.93, p = 0.005) correlated with DPN. The fGLP-1 concentrations were reduced significantly in DPN (p < 0.001). In particular, male patients with DPN had a significantly lower fGLP-1 levels than those without DPN (p < 0.001).Conclusion: The prevalence of DPN among nT2D was 26.6%. Age, smoking, hypertension, HbA1c control, triglyceride, albumin, 24hUA, diabetic retinopathy were the associated risk factors of DPN, and fGLP-1 was negatively correlated with DPN (OR = 0.79, 95% CI 0.67– 0.93, p = 0.005).Keywords: newly diagnosed type 2 diabetes mellitus, diabetic peripheral neuropathy, cardiovascular risk factors, glucagon-like peptide-1 concentrationshttps://www.dovepress.com/diabetic-peripheral-neuropathy-associated-with-cardiovascular-risk-fac-peer-reviewed-fulltext-article-DMSOnewly-diagnosed type 2 diabetes mellitusdiabetic peripheral neuropathycardiovascular risk factorsglucagon-like peptide-1 concentrations |
| spellingShingle | Dinh Le T Phi Thi Nguyen N Thanh Thi Tran H Luong Cong T Ho Thi Nguyen L Do Nhu B Tien Nguyen S Van Ngo M Trung Dinh H Thi Nguyen H Trung Nguyen K Duc-Cuong Le Diabetic Peripheral Neuropathy Associated with Cardiovascular Risk Factors and Glucagon-Like Peptide-1 Concentrations Among Newly Diagnosed Patients with Type 2 Diabetes Mellitus Diabetes, Metabolic Syndrome and Obesity newly-diagnosed type 2 diabetes mellitus diabetic peripheral neuropathy cardiovascular risk factors glucagon-like peptide-1 concentrations |
| title | Diabetic Peripheral Neuropathy Associated with Cardiovascular Risk Factors and Glucagon-Like Peptide-1 Concentrations Among Newly Diagnosed Patients with Type 2 Diabetes Mellitus |
| title_full | Diabetic Peripheral Neuropathy Associated with Cardiovascular Risk Factors and Glucagon-Like Peptide-1 Concentrations Among Newly Diagnosed Patients with Type 2 Diabetes Mellitus |
| title_fullStr | Diabetic Peripheral Neuropathy Associated with Cardiovascular Risk Factors and Glucagon-Like Peptide-1 Concentrations Among Newly Diagnosed Patients with Type 2 Diabetes Mellitus |
| title_full_unstemmed | Diabetic Peripheral Neuropathy Associated with Cardiovascular Risk Factors and Glucagon-Like Peptide-1 Concentrations Among Newly Diagnosed Patients with Type 2 Diabetes Mellitus |
| title_short | Diabetic Peripheral Neuropathy Associated with Cardiovascular Risk Factors and Glucagon-Like Peptide-1 Concentrations Among Newly Diagnosed Patients with Type 2 Diabetes Mellitus |
| title_sort | diabetic peripheral neuropathy associated with cardiovascular risk factors and glucagon like peptide 1 concentrations among newly diagnosed patients with type 2 diabetes mellitus |
| topic | newly-diagnosed type 2 diabetes mellitus diabetic peripheral neuropathy cardiovascular risk factors glucagon-like peptide-1 concentrations |
| url | https://www.dovepress.com/diabetic-peripheral-neuropathy-associated-with-cardiovascular-risk-fac-peer-reviewed-fulltext-article-DMSO |
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