Wiedemann–Steiner Syndrome: Case Report and Review of Literature
Wiedemann–Steiner syndrome (WDSTS) is an autosomal dominant disorder with a broad and variable phenotypic spectrum characterized by intellectual disability, prenatal and postnatal growth retardation, hypertrichosis, characteristic facial features, behavioral problems, and congenital anomalies involv...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/9/10/1545 |
| _version_ | 1797474175153078272 |
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| author | Huan Yu Guijiao Zhang Shengxu Yu Wei Wu |
| author_facet | Huan Yu Guijiao Zhang Shengxu Yu Wei Wu |
| author_sort | Huan Yu |
| collection | DOAJ |
| description | Wiedemann–Steiner syndrome (WDSTS) is an autosomal dominant disorder with a broad and variable phenotypic spectrum characterized by intellectual disability, prenatal and postnatal growth retardation, hypertrichosis, characteristic facial features, behavioral problems, and congenital anomalies involving different systems. Here, we report a five-year-old boy who was diagnosed with WDSTS based on the results of Trio-based whole-exome sequencing and an assessment of his clinical features. He had intellectual disability, short stature, hirsutism, and atypical facial features, including a low hairline, down-slanting palpebral fissures, hypertelorism, long eyelashes, broad and arching eyebrows, synophrys, a bulbous nose, a broad nasal tip, and dental/oral anomalies. However, not all individuals with WDSTS exhibit the classic phenotype, so the spectrum of the disorder can vary widely from relatively atypical facial features to multiple systemic symptoms. Here, we summarize the clinical and molecular spectrum, diagnosis and differential diagnosis, long-term management, and care planning of WDSTS to improve the awareness of both pediatricians and clinical geneticists and to promote the diagnosis and treatment of the disease. |
| first_indexed | 2024-03-09T20:27:25Z |
| format | Article |
| id | doaj.art-9f1da8810fd34fcd8931b2775582e230 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-09T20:27:25Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-9f1da8810fd34fcd8931b2775582e2302023-11-23T23:32:42ZengMDPI AGChildren2227-90672022-10-01910154510.3390/children9101545Wiedemann–Steiner Syndrome: Case Report and Review of LiteratureHuan Yu0Guijiao Zhang1Shengxu Yu2Wei Wu3Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaWiedemann–Steiner syndrome (WDSTS) is an autosomal dominant disorder with a broad and variable phenotypic spectrum characterized by intellectual disability, prenatal and postnatal growth retardation, hypertrichosis, characteristic facial features, behavioral problems, and congenital anomalies involving different systems. Here, we report a five-year-old boy who was diagnosed with WDSTS based on the results of Trio-based whole-exome sequencing and an assessment of his clinical features. He had intellectual disability, short stature, hirsutism, and atypical facial features, including a low hairline, down-slanting palpebral fissures, hypertelorism, long eyelashes, broad and arching eyebrows, synophrys, a bulbous nose, a broad nasal tip, and dental/oral anomalies. However, not all individuals with WDSTS exhibit the classic phenotype, so the spectrum of the disorder can vary widely from relatively atypical facial features to multiple systemic symptoms. Here, we summarize the clinical and molecular spectrum, diagnosis and differential diagnosis, long-term management, and care planning of WDSTS to improve the awareness of both pediatricians and clinical geneticists and to promote the diagnosis and treatment of the disease.https://www.mdpi.com/2227-9067/9/10/1545KMT2Aintellectual disabilityWiedemann–Steiner syndrome |
| spellingShingle | Huan Yu Guijiao Zhang Shengxu Yu Wei Wu Wiedemann–Steiner Syndrome: Case Report and Review of Literature Children KMT2A intellectual disability Wiedemann–Steiner syndrome |
| title | Wiedemann–Steiner Syndrome: Case Report and Review of Literature |
| title_full | Wiedemann–Steiner Syndrome: Case Report and Review of Literature |
| title_fullStr | Wiedemann–Steiner Syndrome: Case Report and Review of Literature |
| title_full_unstemmed | Wiedemann–Steiner Syndrome: Case Report and Review of Literature |
| title_short | Wiedemann–Steiner Syndrome: Case Report and Review of Literature |
| title_sort | wiedemann steiner syndrome case report and review of literature |
| topic | KMT2A intellectual disability Wiedemann–Steiner syndrome |
| url | https://www.mdpi.com/2227-9067/9/10/1545 |
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