The effects of monomer on the diffusion behavior of drug molecules in acrylic pressure-sensitive adhesive
Acrylic pressure-sensitive adhesive (PSA) is widely used in transdermal drug delivery systems (TDDS). In this study, PSAs with different monomer proportion were synthesized, the effects of soft monomer/hard monomer ratio on the diffusion of drug molecules were investigated by Fourier transform infra...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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IOP Publishing
2021-01-01
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| Series: | Materials Research Express |
| Subjects: | |
| Online Access: | https://doi.org/10.1088/2053-1591/abef3e |
| _version_ | 1797746686412455936 |
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| author | Yaxin Wang Jun Qian Minghui Fang Ruilin Guo Yifeng Shi |
| author_facet | Yaxin Wang Jun Qian Minghui Fang Ruilin Guo Yifeng Shi |
| author_sort | Yaxin Wang |
| collection | DOAJ |
| description | Acrylic pressure-sensitive adhesive (PSA) is widely used in transdermal drug delivery systems (TDDS). In this study, PSAs with different monomer proportion were synthesized, the effects of soft monomer/hard monomer ratio on the diffusion of drug molecules were investigated by Fourier transform infrared attenuated total reflection (ATR-FTIR) measurement and molecular dynamics simulation. The accuracy of the diffusion coefficient was confirmed by the consistency of the results from the above two methods. Based on the characterization of diffusion behavior, the diffusion mechanism was revealed. Three dominant factors, which affect the diffusion behavior: the wriggling of the polymer chain, the free volume and the drug-PSA interaction, were discussed. The wriggling of the polymer chain and the free volume of PSA are positive to the diffusion process while drug-PSA interaction is negative. Through the synergy of the three factors, the diffusion rate of drug molecules in PSA can be controlled by adjusting the proportion of soft monomer and hard monomer. |
| first_indexed | 2024-03-12T15:40:22Z |
| format | Article |
| id | doaj.art-9f1e108716174aa1804be50a4c59f835 |
| institution | Directory Open Access Journal |
| issn | 2053-1591 |
| language | English |
| last_indexed | 2024-03-12T15:40:22Z |
| publishDate | 2021-01-01 |
| publisher | IOP Publishing |
| record_format | Article |
| series | Materials Research Express |
| spelling | doaj.art-9f1e108716174aa1804be50a4c59f8352023-08-09T16:01:09ZengIOP PublishingMaterials Research Express2053-15912021-01-018303530710.1088/2053-1591/abef3eThe effects of monomer on the diffusion behavior of drug molecules in acrylic pressure-sensitive adhesiveYaxin Wang0https://orcid.org/0000-0002-3214-5170Jun Qian1https://orcid.org/0000-0002-3242-6706Minghui Fang2Ruilin Guo3Yifeng Shi4Key Laboratory of Specially Functional Polymeric Materials and Related Technology of the Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology , Shanghai, 200237, People’s Republic of ChinaKey Laboratory of Specially Functional Polymeric Materials and Related Technology of the Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology , Shanghai, 200237, People’s Republic of ChinaKey Laboratory of Specially Functional Polymeric Materials and Related Technology of the Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology , Shanghai, 200237, People’s Republic of ChinaKey Laboratory of Specially Functional Polymeric Materials and Related Technology of the Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology , Shanghai, 200237, People’s Republic of ChinaHangzhou Rongfang Pressure Sensitive New Material Co., Ltd, Shanghai, 200237, People’s Republic of ChinaAcrylic pressure-sensitive adhesive (PSA) is widely used in transdermal drug delivery systems (TDDS). In this study, PSAs with different monomer proportion were synthesized, the effects of soft monomer/hard monomer ratio on the diffusion of drug molecules were investigated by Fourier transform infrared attenuated total reflection (ATR-FTIR) measurement and molecular dynamics simulation. The accuracy of the diffusion coefficient was confirmed by the consistency of the results from the above two methods. Based on the characterization of diffusion behavior, the diffusion mechanism was revealed. Three dominant factors, which affect the diffusion behavior: the wriggling of the polymer chain, the free volume and the drug-PSA interaction, were discussed. The wriggling of the polymer chain and the free volume of PSA are positive to the diffusion process while drug-PSA interaction is negative. Through the synergy of the three factors, the diffusion rate of drug molecules in PSA can be controlled by adjusting the proportion of soft monomer and hard monomer.https://doi.org/10.1088/2053-1591/abef3ediffusionpressure-sensitive adhesivemolecular dynamics simulationTDDS |
| spellingShingle | Yaxin Wang Jun Qian Minghui Fang Ruilin Guo Yifeng Shi The effects of monomer on the diffusion behavior of drug molecules in acrylic pressure-sensitive adhesive Materials Research Express diffusion pressure-sensitive adhesive molecular dynamics simulation TDDS |
| title | The effects of monomer on the diffusion behavior of drug molecules in acrylic pressure-sensitive adhesive |
| title_full | The effects of monomer on the diffusion behavior of drug molecules in acrylic pressure-sensitive adhesive |
| title_fullStr | The effects of monomer on the diffusion behavior of drug molecules in acrylic pressure-sensitive adhesive |
| title_full_unstemmed | The effects of monomer on the diffusion behavior of drug molecules in acrylic pressure-sensitive adhesive |
| title_short | The effects of monomer on the diffusion behavior of drug molecules in acrylic pressure-sensitive adhesive |
| title_sort | effects of monomer on the diffusion behavior of drug molecules in acrylic pressure sensitive adhesive |
| topic | diffusion pressure-sensitive adhesive molecular dynamics simulation TDDS |
| url | https://doi.org/10.1088/2053-1591/abef3e |
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