Canonical and Non-Canonical Autophagy in HIV-1 Replication Cycle
Autophagy is a lysosomal-dependent degradative process essential for maintaining cellular homeostasis, and is a key player in innate and adaptive immune responses to intracellular pathogens such as human immunodeficiency virus type 1 (HIV-1). In HIV-1 target cells, autophagy mechanisms can (i) selec...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-09-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/9/10/270 |
| _version_ | 1819071070079025152 |
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| author | Olivier Leymarie Leslie Lepont Clarisse Berlioz-Torrent |
| author_facet | Olivier Leymarie Leslie Lepont Clarisse Berlioz-Torrent |
| author_sort | Olivier Leymarie |
| collection | DOAJ |
| description | Autophagy is a lysosomal-dependent degradative process essential for maintaining cellular homeostasis, and is a key player in innate and adaptive immune responses to intracellular pathogens such as human immunodeficiency virus type 1 (HIV-1). In HIV-1 target cells, autophagy mechanisms can (i) selectively direct viral proteins and viruses for degradation; (ii) participate in the processing and presentation of viral-derived antigens through major histocompatibility complexes; and (iii) contribute to interferon production in response to HIV-1 infection. As a consequence, HIV-1 has evolved different strategies to finely regulate the autophagy pathway to favor its replication and dissemination. HIV-1 notably encodes accessory genes encoding Tat, Nef and Vpu proteins, which are able to perturb and hijack canonical and non-canonical autophagy mechanisms. This review outlines the current knowledge on the complex interplay between autophagy and HIV-1 replication cycle, providing an overview of the autophagy-mediated molecular processes deployed both by infected cells to combat the virus and by HIV-1 to evade antiviral response. |
| first_indexed | 2024-12-21T17:15:59Z |
| format | Article |
| id | doaj.art-9f1e42b4a6f5413f9cf0a20839ebcc1e |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-21T17:15:59Z |
| publishDate | 2017-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-9f1e42b4a6f5413f9cf0a20839ebcc1e2022-12-21T18:56:17ZengMDPI AGViruses1999-49152017-09-0191027010.3390/v9100270v9100270Canonical and Non-Canonical Autophagy in HIV-1 Replication CycleOlivier Leymarie0Leslie Lepont1Clarisse Berlioz-Torrent2Inserm, U1016, Institut Cochin, 75014 Paris, FranceInserm, U1016, Institut Cochin, 75014 Paris, FranceInserm, U1016, Institut Cochin, 75014 Paris, FranceAutophagy is a lysosomal-dependent degradative process essential for maintaining cellular homeostasis, and is a key player in innate and adaptive immune responses to intracellular pathogens such as human immunodeficiency virus type 1 (HIV-1). In HIV-1 target cells, autophagy mechanisms can (i) selectively direct viral proteins and viruses for degradation; (ii) participate in the processing and presentation of viral-derived antigens through major histocompatibility complexes; and (iii) contribute to interferon production in response to HIV-1 infection. As a consequence, HIV-1 has evolved different strategies to finely regulate the autophagy pathway to favor its replication and dissemination. HIV-1 notably encodes accessory genes encoding Tat, Nef and Vpu proteins, which are able to perturb and hijack canonical and non-canonical autophagy mechanisms. This review outlines the current knowledge on the complex interplay between autophagy and HIV-1 replication cycle, providing an overview of the autophagy-mediated molecular processes deployed both by infected cells to combat the virus and by HIV-1 to evade antiviral response.https://www.mdpi.com/1999-4915/9/10/270HIV-1autophagyLC3-associated phagocytosisEnvTatNefVpuLC3 |
| spellingShingle | Olivier Leymarie Leslie Lepont Clarisse Berlioz-Torrent Canonical and Non-Canonical Autophagy in HIV-1 Replication Cycle Viruses HIV-1 autophagy LC3-associated phagocytosis Env Tat Nef Vpu LC3 |
| title | Canonical and Non-Canonical Autophagy in HIV-1 Replication Cycle |
| title_full | Canonical and Non-Canonical Autophagy in HIV-1 Replication Cycle |
| title_fullStr | Canonical and Non-Canonical Autophagy in HIV-1 Replication Cycle |
| title_full_unstemmed | Canonical and Non-Canonical Autophagy in HIV-1 Replication Cycle |
| title_short | Canonical and Non-Canonical Autophagy in HIV-1 Replication Cycle |
| title_sort | canonical and non canonical autophagy in hiv 1 replication cycle |
| topic | HIV-1 autophagy LC3-associated phagocytosis Env Tat Nef Vpu LC3 |
| url | https://www.mdpi.com/1999-4915/9/10/270 |
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