Systemic L-Kynurenine sulfate administration disrupts object recognition memory, alters open field behavior and decreases c-Fos immunopositivity in C57Bl/6 mice

Systemic L-Kynurenine sulfate administration disrupts object recognition memory, alters open field behavior and decreases c-Fos immunopositivity in C57Bl/6 mice

L-Kynurenine (L-KYN) is a central metabolite of tryptophan degradation through the kynurenine pathway (KP). The systemic administration of L-KYN sulfate (L-KYNs) leads to a rapid elevation of the neuroactive KP metabolite kynurenic acid (KYNA). An elevated level of KYNA may have multiple effects on...

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Bibliographic Details
Main Authors: Dániel eVarga, Judit eHerédi, Zita eKánvási, Gyengéné Ruszka Marian, Zsolt eKis, Etsuro eOno, Naoki eIwamori, Tokuko eIwamori, Hiroki eTakakuwa, László eVécsei, József eToldi, Levente eGellért
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-06-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Anxiety
Hippocampus
c-fos
Striatum
open field
C57BL/6 Mice
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00157/full

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