Association of type 2 diabetes mellitus with lung cancer in patients with chronic obstructive pulmonary disease
BackgroundPatients with chronic obstructive pulmonary disease (COPD) have an increased risk of developing lung cancer. Some studies have also suggested that diabetes mellitus (DM) may increase the risk of developing lung cancer. This study aimed to investigate whether type 2 DM (T2DM) is associated...
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1118863/full |
| _version_ | 1797838658743566336 |
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| author | Nam Eun Kim Eun-Hwa Kang Eunhee Ha Ji-Young Lee Jin Hwa Lee |
| author_facet | Nam Eun Kim Eun-Hwa Kang Eunhee Ha Ji-Young Lee Jin Hwa Lee |
| author_sort | Nam Eun Kim |
| collection | DOAJ |
| description | BackgroundPatients with chronic obstructive pulmonary disease (COPD) have an increased risk of developing lung cancer. Some studies have also suggested that diabetes mellitus (DM) may increase the risk of developing lung cancer. This study aimed to investigate whether type 2 DM (T2DM) is associated with an increased risk of lung cancer in patients with COPD.Materials and methodsWe conducted a retrospective analysis on two cohorts: the National Health Insurance Service-National Sample Cohort (NHIS-NSC) of Korea and the Common Data Model (CDM) database of a university hospital. Among patients newly diagnosed with COPD in each cohort, those with a lung cancer diagnosis were included, and a control group was selected through propensity score matching. We used the Kaplan–Meier analysis and Cox proportional hazard models to compare lung cancer incidence between patients with COPD and T2DM and those without T2DM.ResultsIn the NHIS-NSC and CDM cohorts, we enrolled 3,474 and 858 patients with COPD, respectively. In both cohorts, T2DM was associated with an increased risk of lung cancer [NHIS-NSC: adjusted hazard ratio (aHR), 1.20; 95% confidence interval (CI), 1.02–1.41; and CDM: aHR, 1.45; 95% CI, 1.02–2.07). Furthermore, in the NHIS-NSC, among patients with COPD and T2DM, the risk of lung cancer was higher in current smokers than in never-smokers (aHR, 1.45; 95% CI, 1.09–1.91); in smokers with ≥30 pack-years than in never-smokers (aHR, 1.82; 95% CI, 1.49–2.25); and in rural residents than in metropolitan residents (aHR, 1.33; 95% CI, 1.06–1.68).ConclusionOur findings suggest that patients with COPD and T2DM may have an increased risk of developing lung cancer compared to those without T2DM. |
| first_indexed | 2024-04-09T15:45:30Z |
| format | Article |
| id | doaj.art-9f1f26f715054a7cb4255128eb405d97 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-09T15:45:30Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-9f1f26f715054a7cb4255128eb405d972023-04-27T04:28:39ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-04-011010.3389/fmed.2023.11188631118863Association of type 2 diabetes mellitus with lung cancer in patients with chronic obstructive pulmonary diseaseNam Eun Kim0Eun-Hwa Kang1Eunhee Ha2Ji-Young Lee3Jin Hwa Lee4Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Republic of KoreaInformatization Department, Ewha Womans University Medical Center, Seoul, Republic of KoreaGraduate Program in System Health Science and Engineering, Department of Environmental Medicine, College of Medicine, Ewha Medical Research Institute, Ewha Womans University, Seoul, Republic of KoreaInflammation-Cancer Microenvironment Research Center, College of Medicine, Ewha Womans University, Seoul, Republic of KoreaDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Republic of KoreaBackgroundPatients with chronic obstructive pulmonary disease (COPD) have an increased risk of developing lung cancer. Some studies have also suggested that diabetes mellitus (DM) may increase the risk of developing lung cancer. This study aimed to investigate whether type 2 DM (T2DM) is associated with an increased risk of lung cancer in patients with COPD.Materials and methodsWe conducted a retrospective analysis on two cohorts: the National Health Insurance Service-National Sample Cohort (NHIS-NSC) of Korea and the Common Data Model (CDM) database of a university hospital. Among patients newly diagnosed with COPD in each cohort, those with a lung cancer diagnosis were included, and a control group was selected through propensity score matching. We used the Kaplan–Meier analysis and Cox proportional hazard models to compare lung cancer incidence between patients with COPD and T2DM and those without T2DM.ResultsIn the NHIS-NSC and CDM cohorts, we enrolled 3,474 and 858 patients with COPD, respectively. In both cohorts, T2DM was associated with an increased risk of lung cancer [NHIS-NSC: adjusted hazard ratio (aHR), 1.20; 95% confidence interval (CI), 1.02–1.41; and CDM: aHR, 1.45; 95% CI, 1.02–2.07). Furthermore, in the NHIS-NSC, among patients with COPD and T2DM, the risk of lung cancer was higher in current smokers than in never-smokers (aHR, 1.45; 95% CI, 1.09–1.91); in smokers with ≥30 pack-years than in never-smokers (aHR, 1.82; 95% CI, 1.49–2.25); and in rural residents than in metropolitan residents (aHR, 1.33; 95% CI, 1.06–1.68).ConclusionOur findings suggest that patients with COPD and T2DM may have an increased risk of developing lung cancer compared to those without T2DM.https://www.frontiersin.org/articles/10.3389/fmed.2023.1118863/fullchronic obstructive pulmonary diseasediabetes mellituslung cancersmokingcohort study |
| spellingShingle | Nam Eun Kim Eun-Hwa Kang Eunhee Ha Ji-Young Lee Jin Hwa Lee Association of type 2 diabetes mellitus with lung cancer in patients with chronic obstructive pulmonary disease Frontiers in Medicine chronic obstructive pulmonary disease diabetes mellitus lung cancer smoking cohort study |
| title | Association of type 2 diabetes mellitus with lung cancer in patients with chronic obstructive pulmonary disease |
| title_full | Association of type 2 diabetes mellitus with lung cancer in patients with chronic obstructive pulmonary disease |
| title_fullStr | Association of type 2 diabetes mellitus with lung cancer in patients with chronic obstructive pulmonary disease |
| title_full_unstemmed | Association of type 2 diabetes mellitus with lung cancer in patients with chronic obstructive pulmonary disease |
| title_short | Association of type 2 diabetes mellitus with lung cancer in patients with chronic obstructive pulmonary disease |
| title_sort | association of type 2 diabetes mellitus with lung cancer in patients with chronic obstructive pulmonary disease |
| topic | chronic obstructive pulmonary disease diabetes mellitus lung cancer smoking cohort study |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1118863/full |
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