Prenatal exposure to phthalate and decreased body mass index of children: a systematic review and meta-analysis
Abstract Phthalates are well-known endocrine-disrupting chemicals. Many detrimental health effects of phthalates were investigated, but studies on the association of phthalates with obesity in children showed inconsistent results. Thus, this systematic review and meta-analysis were performed to clar...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-13154-9 |
| _version_ | 1818238643329826816 |
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| author | Dong-Wook Lee Hyun-Mook Lim Joong-Yub Lee Kyung-Bok Min Choong-Ho Shin Young-Ah Lee Yun-Chul Hong |
| author_facet | Dong-Wook Lee Hyun-Mook Lim Joong-Yub Lee Kyung-Bok Min Choong-Ho Shin Young-Ah Lee Yun-Chul Hong |
| author_sort | Dong-Wook Lee |
| collection | DOAJ |
| description | Abstract Phthalates are well-known endocrine-disrupting chemicals. Many detrimental health effects of phthalates were investigated, but studies on the association of phthalates with obesity in children showed inconsistent results. Thus, this systematic review and meta-analysis were performed to clarify whether prenatal and postnatal exposures to phthalates are associated with physical growth disturbances in children. We performed the systematic review and meta-analysis following the PRISMA 2020 statement guidelines, and found 39 studies that met our inclusion criteria, including 22 longitudinal and 17 cross-sectional studies. We observed a significant negative association between the prenatal exposure to DEHP and the body mass index (BMI) z-score of the offspring (β = − 0.05; 95% CI: − 0.10, − 0.001) in the meta-analysis, while no significant association between the prenatal exposure to DEHP and the body fat percentage of the offspring was observed (β = 0.01; 95% CI: − 0.41, 0.44). In the systematic review, studies on the association between phthalates exposure in childhood and obesity were inconsistent. Prenatal exposure to phthalates was found to be associated with decreased BMI z-score in children, but not associated with body fat percentage. Our findings suggest that phthalates disturb the normal muscle growth of children, rather than induce obesity, as previous studies have hypothesized. |
| first_indexed | 2024-12-12T12:44:55Z |
| format | Article |
| id | doaj.art-9f2155bad5d8498e802fc1fa4e22b7bb |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-12T12:44:55Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-9f2155bad5d8498e802fc1fa4e22b7bb2022-12-22T00:24:08ZengNature PortfolioScientific Reports2045-23222022-05-0112111810.1038/s41598-022-13154-9Prenatal exposure to phthalate and decreased body mass index of children: a systematic review and meta-analysisDong-Wook Lee0Hyun-Mook Lim1Joong-Yub Lee2Kyung-Bok Min3Choong-Ho Shin4Young-Ah Lee5Yun-Chul Hong6Public Healthcare Center, Seoul National University HospitalCOMWEL Daejeon Hospital, Korea Workers’ Compensation & Welfare ServiceDepartment of Preventive Medicine, Seoul National University College of MedicineDepartment of Preventive Medicine, Seoul National University College of MedicineDepartment of Pediatrics, Seoul National University College of MedicineDepartment of Pediatrics, Seoul National University College of MedicineDepartment of Humans Systems Medicine, Seoul National University College of MedicineAbstract Phthalates are well-known endocrine-disrupting chemicals. Many detrimental health effects of phthalates were investigated, but studies on the association of phthalates with obesity in children showed inconsistent results. Thus, this systematic review and meta-analysis were performed to clarify whether prenatal and postnatal exposures to phthalates are associated with physical growth disturbances in children. We performed the systematic review and meta-analysis following the PRISMA 2020 statement guidelines, and found 39 studies that met our inclusion criteria, including 22 longitudinal and 17 cross-sectional studies. We observed a significant negative association between the prenatal exposure to DEHP and the body mass index (BMI) z-score of the offspring (β = − 0.05; 95% CI: − 0.10, − 0.001) in the meta-analysis, while no significant association between the prenatal exposure to DEHP and the body fat percentage of the offspring was observed (β = 0.01; 95% CI: − 0.41, 0.44). In the systematic review, studies on the association between phthalates exposure in childhood and obesity were inconsistent. Prenatal exposure to phthalates was found to be associated with decreased BMI z-score in children, but not associated with body fat percentage. Our findings suggest that phthalates disturb the normal muscle growth of children, rather than induce obesity, as previous studies have hypothesized.https://doi.org/10.1038/s41598-022-13154-9 |
| spellingShingle | Dong-Wook Lee Hyun-Mook Lim Joong-Yub Lee Kyung-Bok Min Choong-Ho Shin Young-Ah Lee Yun-Chul Hong Prenatal exposure to phthalate and decreased body mass index of children: a systematic review and meta-analysis Scientific Reports |
| title | Prenatal exposure to phthalate and decreased body mass index of children: a systematic review and meta-analysis |
| title_full | Prenatal exposure to phthalate and decreased body mass index of children: a systematic review and meta-analysis |
| title_fullStr | Prenatal exposure to phthalate and decreased body mass index of children: a systematic review and meta-analysis |
| title_full_unstemmed | Prenatal exposure to phthalate and decreased body mass index of children: a systematic review and meta-analysis |
| title_short | Prenatal exposure to phthalate and decreased body mass index of children: a systematic review and meta-analysis |
| title_sort | prenatal exposure to phthalate and decreased body mass index of children a systematic review and meta analysis |
| url | https://doi.org/10.1038/s41598-022-13154-9 |
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