Structural basis of transcription inhibition by the DNA mimic protein Ocr of bacteriophage T7

Structural basis of transcription inhibition by the DNA mimic protein Ocr of bacteriophage T7

Bacteriophage T7 infects Escherichia coli and evades the host restriction/modification system. The Ocr protein of T7 was shown to exist as a dimer mimicking DNA and to bind to host restriction enzymes, thus preventing the degradation of the viral genome by the host. Here we report that Ocr can also...

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Bibliographic Details
Main Authors: Fuzhou Ye, Ioly Kotta-Loizou, Milija Jovanovic, Xiaojiao Liu, David TF Dryden, Martin Buck, Xiaodong Zhang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-02-01
Series:eLife
Subjects:
Ocr
bacteriophage
transcription
DNA mimicry proteins
RNAP
cryo EM
Online Access:https://elifesciences.org/articles/52125

Internet

https://elifesciences.org/articles/52125

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