Metabolic Profiling Indicates Diversity in the Metabolic Physiologies Associated With Maternal Postpartum Depressive Symptoms
Background: Postpartum depression (PPD) is a devastating disease requiring improvements in diagnosis and prevention. Blood metabolomics identifies biological markers discriminatory between women with and those without antenatal depressive symptoms. Whether this cutting-edge method can be applied to...
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.685656/full |
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| author | Emma Bränn Christina Malavaki Emma Fransson Emma Fransson Maria-Konstantina Ioannidi Maria-Konstantina Ioannidi Hanna E. Henriksson Fotios C. Papadopoulos George P. Chrousos Maria I. Klapa Alkistis Skalkidou |
| author_facet | Emma Bränn Christina Malavaki Emma Fransson Emma Fransson Maria-Konstantina Ioannidi Maria-Konstantina Ioannidi Hanna E. Henriksson Fotios C. Papadopoulos George P. Chrousos Maria I. Klapa Alkistis Skalkidou |
| author_sort | Emma Bränn |
| collection | DOAJ |
| description | Background: Postpartum depression (PPD) is a devastating disease requiring improvements in diagnosis and prevention. Blood metabolomics identifies biological markers discriminatory between women with and those without antenatal depressive symptoms. Whether this cutting-edge method can be applied to postpartum depressive symptoms merits further investigation.Methods: As a substudy within the Biology, Affect, Stress, Imagine and Cognition Study, 24 women with PPD symptom (PPDS) assessment at 6 weeks postpartum were included. Controls were selected as having a score of ≤ 6 and PPDS cases as ≥12 on the Edinburgh Postnatal Depression Scale. Blood plasma was collected at 10 weeks postpartum and analyzed with gas chromatography–mass spectrometry metabolomics.Results: Variations of metabolomic profiles within the PPDS samples were identified. One cluster showed altered kidney function, whereas the other, a metabolic syndrome profile, both previously associated with depression. Five metabolites (glycerol, threonine, 2-hydroxybutanoic acid, erythritol, and phenylalanine) showed higher abundance among women with PPDSs, indicating perturbations in the serine/threonine and glycerol lipid metabolism, suggesting oxidative stress conditions.Conclusions: Alterations in certain metabolites were associated with depressive pathophysiology postpartum, whereas diversity in PPDS physiologies was revealed. Hence, plasma metabolic profiling could be considered in diagnosis and pathophysiological investigation of PPD toward providing clues for treatment. Future studies require standardization of various subgroups with respect to symptom onset, lifestyle, and comorbidities. |
| first_indexed | 2024-12-17T07:17:39Z |
| format | Article |
| id | doaj.art-9f21e3f75b154a3ca6fb3c7d92cd0fdd |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-17T07:17:39Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-9f21e3f75b154a3ca6fb3c7d92cd0fdd2022-12-21T21:58:52ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402021-06-011210.3389/fpsyt.2021.685656685656Metabolic Profiling Indicates Diversity in the Metabolic Physiologies Associated With Maternal Postpartum Depressive SymptomsEmma Bränn0Christina Malavaki1Emma Fransson2Emma Fransson3Maria-Konstantina Ioannidi4Maria-Konstantina Ioannidi5Hanna E. Henriksson6Fotios C. Papadopoulos7George P. Chrousos8Maria I. Klapa9Alkistis Skalkidou10Department of Women's and Children's Health, Uppsala University, Uppsala, SwedenMetabolic Engineering and Systems Biology Laboratory, Institute of Chemical Engineering Sciences, Foundation for Research and Technology-Hellas, Patras, GreeceDepartment of Women's and Children's Health, Uppsala University, Uppsala, SwedenDepartment of Microbiology, Tumor and Cell Biology, Centre for Translational Microbiome Research, Karolinska Institute, Stockholm, SwedenMetabolic Engineering and Systems Biology Laboratory, Institute of Chemical Engineering Sciences, Foundation for Research and Technology-Hellas, Patras, GreeceDepartment of Biology, University of Patras, Patras, GreeceDepartment of Women's and Children's Health, Uppsala University, Uppsala, SwedenDepartment of Neuroscience, Psychiatry, Uppsala University, Uppsala, SwedenUniversity Research Institute of Maternal and Child Health and Precision Medicine, UNESCO Chair on Adolescent Health Care, Medical School, National and Kapodistrian University of Athens, Athens, GreeceMetabolic Engineering and Systems Biology Laboratory, Institute of Chemical Engineering Sciences, Foundation for Research and Technology-Hellas, Patras, GreeceDepartment of Women's and Children's Health, Uppsala University, Uppsala, SwedenBackground: Postpartum depression (PPD) is a devastating disease requiring improvements in diagnosis and prevention. Blood metabolomics identifies biological markers discriminatory between women with and those without antenatal depressive symptoms. Whether this cutting-edge method can be applied to postpartum depressive symptoms merits further investigation.Methods: As a substudy within the Biology, Affect, Stress, Imagine and Cognition Study, 24 women with PPD symptom (PPDS) assessment at 6 weeks postpartum were included. Controls were selected as having a score of ≤ 6 and PPDS cases as ≥12 on the Edinburgh Postnatal Depression Scale. Blood plasma was collected at 10 weeks postpartum and analyzed with gas chromatography–mass spectrometry metabolomics.Results: Variations of metabolomic profiles within the PPDS samples were identified. One cluster showed altered kidney function, whereas the other, a metabolic syndrome profile, both previously associated with depression. Five metabolites (glycerol, threonine, 2-hydroxybutanoic acid, erythritol, and phenylalanine) showed higher abundance among women with PPDSs, indicating perturbations in the serine/threonine and glycerol lipid metabolism, suggesting oxidative stress conditions.Conclusions: Alterations in certain metabolites were associated with depressive pathophysiology postpartum, whereas diversity in PPDS physiologies was revealed. Hence, plasma metabolic profiling could be considered in diagnosis and pathophysiological investigation of PPD toward providing clues for treatment. Future studies require standardization of various subgroups with respect to symptom onset, lifestyle, and comorbidities.https://www.frontiersin.org/articles/10.3389/fpsyt.2021.685656/fullpostpartum depressionmetabolomicsperinatal depressionpregnancyGC-MS metabolic profilingmolecular psychiatry |
| spellingShingle | Emma Bränn Christina Malavaki Emma Fransson Emma Fransson Maria-Konstantina Ioannidi Maria-Konstantina Ioannidi Hanna E. Henriksson Fotios C. Papadopoulos George P. Chrousos Maria I. Klapa Alkistis Skalkidou Metabolic Profiling Indicates Diversity in the Metabolic Physiologies Associated With Maternal Postpartum Depressive Symptoms Frontiers in Psychiatry postpartum depression metabolomics perinatal depression pregnancy GC-MS metabolic profiling molecular psychiatry |
| title | Metabolic Profiling Indicates Diversity in the Metabolic Physiologies Associated With Maternal Postpartum Depressive Symptoms |
| title_full | Metabolic Profiling Indicates Diversity in the Metabolic Physiologies Associated With Maternal Postpartum Depressive Symptoms |
| title_fullStr | Metabolic Profiling Indicates Diversity in the Metabolic Physiologies Associated With Maternal Postpartum Depressive Symptoms |
| title_full_unstemmed | Metabolic Profiling Indicates Diversity in the Metabolic Physiologies Associated With Maternal Postpartum Depressive Symptoms |
| title_short | Metabolic Profiling Indicates Diversity in the Metabolic Physiologies Associated With Maternal Postpartum Depressive Symptoms |
| title_sort | metabolic profiling indicates diversity in the metabolic physiologies associated with maternal postpartum depressive symptoms |
| topic | postpartum depression metabolomics perinatal depression pregnancy GC-MS metabolic profiling molecular psychiatry |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.685656/full |
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