Metabolomics approach: Interpretation of changes in rat plasma metabolites after solifenacin treatment

Metabolomics approach: Interpretation of changes in rat plasma metabolites after solifenacin treatment

Abstract Changes in metabolite levels of patients using the long-term drug can be comprehensively demonstrated by pharmacometabolomic studies. In this study, biological alterations induced by the administration of solifenacin succinate were investigated with a pharmacometabolomics approach on rat me...

Full description

Bibliographic Details
Main Authors:	Tugrul Cagri Akman, Yucel Kadioglu, Onur Senol, Beyzagul Erkayman
Format:	Article
Language:	English
Published:	Universidade de São Paulo 2022-11-01
Series:	Brazilian Journal of Pharmaceutical Sciences
Subjects:	Solifenacin succinate Metabolomics Rat LC-Q-TOF/MS/MS
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100755&tlng=en

Similar Items

Investigation of the metabolic difference between ST-elevated myocardial infarction and non-ST-elevated myocardial infarction via LC/Q-TOF/MS/MS
by: Gulsah Gundogdu, et al.
Published: (2019-10-01)

The relation between the storage symptoms before and after transurethral resection of the prostate, analysis of the risk factors and the prevention of the symptoms with solifenacin
by: Timucin Sipal, et al.

Efficacy of Additional Solifenacin Succinate Therapy for Storage Symptoms in Females with Uncomplicated Lower Urinary Tract Infection: The SOLUTION Randomized Controlled Trial
by: Harrina Erlianti Rahardjo, et al.
Published: (2018-10-01)

Effectiveness and durability of solifenacin versus percutaneous tibial nerve stimulation versus their combination for the treatment of women with overactive bladder syndrome: a randomized controlled study with a follow-up of ten months
by: Carlo Vecchioli-Scaldazza, et al.

Novel Bioequivalent Tablet of Solifenacin Succinate Prepared Using Direct Compression Technique for Improved Chemical Stability
by: Do Hwan Kim, et al.
Published: (2023-06-01)

Metabolomics reveals differences in metabolite profiles between wild and cultivated Tetrastigmae Radix
by: Haijie Chen, et al.
Published: (2024-01-01)

Biotransformation of Timosaponin BII into Seven Characteristic Metabolites by the Gut Microbiota
by: Guo-Ming Dong, et al.
Published: (2021-06-01)

Insight into the relationship between metabolite dynamic changes and microorganisms of sea urchin (S. intermedius) gonads during storage
by: Wen-qiang Cai, et al.
Published: (2023-06-01)

Pooled solifenacin overactive bladder trial data: Creation, validation and analysis of an integrated database
by: Christopher R. Chapple, et al.
Published: (2016-12-01)

Persistence and adherence of solifenacin treatment for Japanese women with overactive bladder
by: Minoru Kobayashi, et al.
Published: (2012-10-01)

Metabolomic Study of Biochemical Changes Related to Toxicity Induced by Bupleurotoxin Using LC-MS Coupled with a Pattern Recognition Approach
by: Zhong-Xiao Zhang, et al.
Published: (2015-01-01)

A comparison of the efficacy and tolerability of treating primary nocturnal enuresis with Solifenacin Plus Desmopressin, Tolterodine Plus Desmopressin, and Desmopressin alone: a randomized controlled clinical trial
by: Parvin Mousavi Ghanavati, et al.
Published: (2020-11-01)

Study on plasma metabolomics for HIV/AIDS patients treated by HAART based on LC/MS-MS
by: Donghui Lao, et al.
Published: (2022-08-01)

Targeted metabolome analysis reveals accumulation of metabolites in testa of four peanut germplasms
by: Kun Zhang, et al.
Published: (2022-09-01)

Solifenacin in overactive bladder syndrome: pharmacoeconomic analysis
by: Sergio Iannazzo, et al.
Published: (2008-03-01)

The Effect of Solifenacin on Cognitive Function following Stroke
by: Jin-Woo Park
Published: (2013-05-01)

Solifenacin and Tolterodine are Equally Effective in the Treatment of Overactive Bladder Symptoms
by: Chen-Hsun Ho, et al.
Published: (2010-10-01)

Non-targeted plasma metabolome of early and late lactation gilts
by: Lea A Rempel, et al.
Published: (2016-11-01)

Impact of Exercise and Aging on Rat Urine and Blood Metabolome. An LC-MS Based Metabolomics Longitudinal Study
by: Olga Deda, et al.
Published: (2017-02-01)

Transforming of Triptolide into Characteristic Metabolites by the Gut Microbiota
by: Ran Peng, et al.
Published: (2020-01-01)

Towards the Fecal Metabolome Derived from Moderate Red Wine Intake
by: Ana Jiménez-Girón, et al.
Published: (2014-12-01)

Analysis of Metabolomics Datasets with High-Performance Computing and Metabolite Atlases
by: Yushu Yao, et al.
Published: (2015-07-01)

Metabolomic Analysis of Response to Nitrogen-Limiting Conditions in <i>Yarrowia</i> spp.
by: Sivamoke Dissook, et al.
Published: (2020-12-01)

Characterization of ornidazole metabolites in human bile after intraveneous doses by ultraperformance liquid chromatography/quadrupole time-of-flight mass spectrometry
by: Jiangbo Du, et al.
Published: (2012-04-01)

Comparative analysis of constitutes and metabolites for traditional Chinese medicine using IDA and SWATH data acquisition modes on LC-Q-TOF MS
by: Dian Kang, et al.
Published: (2020-12-01)

Effects of Fermentation Period on the Non-Volatile Metabolites of Chinese Ultra-Long-Term Solid Fermented Kohlrabi Based on Non-Targeted Metabolomic Analysis
by: Xiaohan Jia, et al.
Published: (2023-08-01)

Metabolomics profiling to characterize cerebral ischemia-reperfusion injury in mice
by: Qiong Chen, et al.
Published: (2023-02-01)

Identification of Sanguinarine Metabolites in Rats Using UPLC-Q-TOF-MS/MS
by: Mengting Liu, et al.
Published: (2023-11-01)

Widely Targeted HPLC-MS/MS Metabolomics Analysis Reveals Natural Metabolic Insights in Insects
by: Zhaoxin Li, et al.
Published: (2023-06-01)

Convergence of Plasma Metabolomics and Proteomics Analysis to Discover Signatures of High-Grade Serous Ovarian Cancer
by: Hee-Sung Ahn, et al.
Published: (2020-11-01)

Insight into the mechanisms of therapeutic hypothermia for asphyxia cardiac arrest using a comprehensive approach of GC-MS/MS and UPLC-Q-TOF-MS/MS based on serum metabolomics
by: Yiyuan Zhang, et al.
Published: (2023-06-01)

NMR Spectroscopy for Metabolomics Research
by: Abdul-Hamid Emwas, et al.
Published: (2019-06-01)

Metabolomic Analysis of Germinated Brown Rice at Different Germination Stages
by: Hoon Kim, et al.
Published: (2020-08-01)

Metabolomic evaluation of Euphorbia pekinensis induced nephrotoxicity in rats
by: Zhenzhen Liu, et al.
Published: (2018-01-01)

Metabolomics reveals the mechanism of action of meropenem and amikacin combined in the treatment of Pseudomonas aeruginosa
by: Hai Yang, et al.
Published: (2023-12-01)

The Urinary Metabolome of Newborns with Perinatal Complications
by: Yamilé López-Hernández, et al.
Published: (2024-01-01)

Metabolomic analyses uncover an inhibitory effect of niclosamide on mitochondrial membrane potential in cholangiocarcinoma cells
by: Thanaporn Kulthawatsiri, et al.
Published: (2023-11-01)

A Review of Liquid Chromatography-Mass Spectrometry Strategies for the Analyses of Metabolomics Induced by Microplastics
by: Kuan-Lu Wu, et al.
Published: (2023-04-01)

Serum biomarkers of the calcium-deficient rats identified by metabolomics based on UPLC/Q-TOF MS/MS
by: Fanyu Meng, et al.
Published: (2020-11-01)

High precision mass measurements for wine metabolomics
by: Chloé eRoullier-Gall, et al.
Published: (2014-11-01)