Maslinic acid solid lipid nanoparticles as hydrophobic anticancer drug carriers: Formulation, in vitro activity and in vivo biodistribution

Maslinic acid solid lipid nanoparticles as hydrophobic anticancer drug carriers: Formulation, in vitro activity and in vivo biodistribution

Maslinic acid (MA) is a natural pentacyclic triterpenoid with inherent antitumor activity which has a very low solubility in water. MA solid lipid nanoparticles (SLNs) were prepared using Poloxamer 407 and Dicarboxylic acid-Poloxamer 407 as surfactants. Both MA SLNs are monodisperse, with sizes arou...

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Bibliographic Details
Main Authors: Aixa Aguilera-Garrido, Pablo Graván, Saúl A. Navarro-Marchal, Marta Medina-O’Donnell, Andrés Parra, María José Gálvez-Ruiz, Juan Antonio Marchal, Francisco Galisteo-González
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Maslinic acid
Curcumin
Solid lipid nanoparticles
Poloxamer
Pancreatic cancer
Breast cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223006182

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