EPOR mRNA level: A valuable prognostic indicator for patients with ER+ breast cancer
Objective: To explore the expression level and prognostic significance of erythropoietin receptor (EPOR) in patients with breast cancer (BRCA) based on estrogen receptor (ER) status and different molecular subtypes. Methods: The Cancer Genome Atlas (TCGA) and GTEx data were collected in GEPIA initia...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Asian Pacific Journal of Tropical Medicine |
| Subjects: | |
| Online Access: | http://www.apjtm.org/article.asp?issn=1995-7645;year=2018;volume=11;issue=4;spage=297;epage=304;aulast=Pan |
| _version_ | 1818187637391884288 |
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| author | Jing Pan Xing-Hua Han Wei Wang Yue-Yin Pan |
| author_facet | Jing Pan Xing-Hua Han Wei Wang Yue-Yin Pan |
| author_sort | Jing Pan |
| collection | DOAJ |
| description | Objective: To explore the expression level and prognostic significance of erythropoietin receptor (EPOR) in patients with breast cancer (BRCA) based on estrogen receptor (ER) status and different molecular subtypes. Methods: The Cancer Genome Atlas (TCGA) and GTEx data were collected in GEPIA initially to identify the dysregulated genes. Further, bc- GenExMiner 4.1 online bioinformatics tool was used to evaluate EPOR mRNA differential expression level according to different classification of clinicopathologic parameters in patients with breast cancer. Additionally, the prognostic value between EPOR mRNA expression and free survival of metastatic relapse (MR) or any event (AE, namely any relapse or death) in patients with breast cancer was done. Results: EPOR mRNA was significantly downregulated in BRCA (1 085 cases) compared to normal tissues (291 cases) (P<0.05). Univariate Cox analysis revealed that high EPOR mRNA expression was remarkably correlated to a decreased risk of MR (HR: 0.79, P<0.000 1) and AE (HR: 0.87, P =0.000 7) especially in breast cancer patients with ER+. Besides, high EPOR mRNA level also associated with a favorable MR- free survival (HR: 0.81, P =0.007 2) and AE-free survival (HR: 0.88, P =0.029 9) in ER+ breast cancer patients. However, no similar above phenomenon was detected in ER- patients. Moreover, the subsequent prognostic adjusted analyses and univariate Cox analysis of AE based on SSP or SCM molecular subtypes validated the above results. Conclusion: EPOR mRNA level is a valuable prognostic indicator for patients with ER+ breast cancer. |
| first_indexed | 2024-12-11T23:14:12Z |
| format | Article |
| id | doaj.art-9f285b4e61b64efc90f9130ff13e7f9e |
| institution | Directory Open Access Journal |
| issn | 2352-4146 |
| language | English |
| last_indexed | 2024-12-11T23:14:12Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Pacific Journal of Tropical Medicine |
| spelling | doaj.art-9f285b4e61b64efc90f9130ff13e7f9e2022-12-22T00:46:36ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Tropical Medicine2352-41462018-01-0111429730410.4103/1995-7645.231471EPOR mRNA level: A valuable prognostic indicator for patients with ER+ breast cancerJing PanXing-Hua HanWei WangYue-Yin PanObjective: To explore the expression level and prognostic significance of erythropoietin receptor (EPOR) in patients with breast cancer (BRCA) based on estrogen receptor (ER) status and different molecular subtypes. Methods: The Cancer Genome Atlas (TCGA) and GTEx data were collected in GEPIA initially to identify the dysregulated genes. Further, bc- GenExMiner 4.1 online bioinformatics tool was used to evaluate EPOR mRNA differential expression level according to different classification of clinicopathologic parameters in patients with breast cancer. Additionally, the prognostic value between EPOR mRNA expression and free survival of metastatic relapse (MR) or any event (AE, namely any relapse or death) in patients with breast cancer was done. Results: EPOR mRNA was significantly downregulated in BRCA (1 085 cases) compared to normal tissues (291 cases) (P<0.05). Univariate Cox analysis revealed that high EPOR mRNA expression was remarkably correlated to a decreased risk of MR (HR: 0.79, P<0.000 1) and AE (HR: 0.87, P =0.000 7) especially in breast cancer patients with ER+. Besides, high EPOR mRNA level also associated with a favorable MR- free survival (HR: 0.81, P =0.007 2) and AE-free survival (HR: 0.88, P =0.029 9) in ER+ breast cancer patients. However, no similar above phenomenon was detected in ER- patients. Moreover, the subsequent prognostic adjusted analyses and univariate Cox analysis of AE based on SSP or SCM molecular subtypes validated the above results. Conclusion: EPOR mRNA level is a valuable prognostic indicator for patients with ER+ breast cancer.http://www.apjtm.org/article.asp?issn=1995-7645;year=2018;volume=11;issue=4;spage=297;epage=304;aulast=Panbreast cancereporprognosisbioinformatics |
| spellingShingle | Jing Pan Xing-Hua Han Wei Wang Yue-Yin Pan EPOR mRNA level: A valuable prognostic indicator for patients with ER+ breast cancer Asian Pacific Journal of Tropical Medicine breast cancer epor prognosis bioinformatics |
| title | EPOR mRNA level: A valuable prognostic indicator for patients with ER+ breast cancer |
| title_full | EPOR mRNA level: A valuable prognostic indicator for patients with ER+ breast cancer |
| title_fullStr | EPOR mRNA level: A valuable prognostic indicator for patients with ER+ breast cancer |
| title_full_unstemmed | EPOR mRNA level: A valuable prognostic indicator for patients with ER+ breast cancer |
| title_short | EPOR mRNA level: A valuable prognostic indicator for patients with ER+ breast cancer |
| title_sort | epor mrna level a valuable prognostic indicator for patients with er breast cancer |
| topic | breast cancer epor prognosis bioinformatics |
| url | http://www.apjtm.org/article.asp?issn=1995-7645;year=2018;volume=11;issue=4;spage=297;epage=304;aulast=Pan |
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