Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge
Irradiation depletes brain microglia cells and induces replenishment of the pool by bone marrow (BM)-derived macrophage. Here the authors show, using mouse BM chimera, that BM-derived macrophages establish long-term residency in the brain, but remain distinct from resident microglia in their transcr...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-07548-5 |
| _version_ | 1818735350038659072 |
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| author | Anat Shemer Jonathan Grozovski Tuan Leng Tay Jenhan Tao Alon Volaski Patrick Süß Alberto Ardura-Fabregat Mor Gross-Vered Jung-Seok Kim Eyal David Louise Chappell-Maor Lars Thielecke Christopher K. Glass Kerstin Cornils Marco Prinz Steffen Jung |
| author_facet | Anat Shemer Jonathan Grozovski Tuan Leng Tay Jenhan Tao Alon Volaski Patrick Süß Alberto Ardura-Fabregat Mor Gross-Vered Jung-Seok Kim Eyal David Louise Chappell-Maor Lars Thielecke Christopher K. Glass Kerstin Cornils Marco Prinz Steffen Jung |
| author_sort | Anat Shemer |
| collection | DOAJ |
| description | Irradiation depletes brain microglia cells and induces replenishment of the pool by bone marrow (BM)-derived macrophage. Here the authors show, using mouse BM chimera, that BM-derived macrophages establish long-term residency in the brain, but remain distinct from resident microglia in their transcriptome and gene accessibility landscape. |
| first_indexed | 2024-12-18T00:19:51Z |
| format | Article |
| id | doaj.art-9f28b09877e64569b86de53bc8767168 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T00:19:51Z |
| publishDate | 2018-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-9f28b09877e64569b86de53bc87671682022-12-21T21:27:23ZengNature PortfolioNature Communications2041-17232018-12-019111610.1038/s41467-018-07548-5Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challengeAnat Shemer0Jonathan Grozovski1Tuan Leng Tay2Jenhan Tao3Alon Volaski4Patrick Süß5Alberto Ardura-Fabregat6Mor Gross-Vered7Jung-Seok Kim8Eyal David9Louise Chappell-Maor10Lars Thielecke11Christopher K. Glass12Kerstin Cornils13Marco Prinz14Steffen Jung15Department of Immunology, Weizmann Institute of ScienceDepartment of Immunology, Weizmann Institute of ScienceCluster of Excellence BrainLinks-BrainTools, University of FreiburgDepartment of Cellular and Molecular Medicine, University of California, San DiegoDepartment of Immunology, Weizmann Institute of ScienceInstitute of Neuropathology, Medical Faculty, University of FreiburgInstitute of Neuropathology, Medical Faculty, University of FreiburgDepartment of Immunology, Weizmann Institute of ScienceDepartment of Immunology, Weizmann Institute of ScienceDepartment of Immunology, Weizmann Institute of ScienceDepartment of Immunology, Weizmann Institute of ScienceInstitute for Medical Informatics and Biometry, Faculty of Medicine Carl Gustav Carus, Technische Universität DresdenDepartment of Cellular and Molecular Medicine, University of California, San DiegoUniversity Medical Center Hamburg-Eppendorf, Department of Pediatric Hematology and Oncology, Division of Pediatric Stem Cell Transplantation and Immunology and Research Institute, Children’s Cancer Center HamburgInstitute of Neuropathology, Medical Faculty, University of FreiburgDepartment of Immunology, Weizmann Institute of ScienceIrradiation depletes brain microglia cells and induces replenishment of the pool by bone marrow (BM)-derived macrophage. Here the authors show, using mouse BM chimera, that BM-derived macrophages establish long-term residency in the brain, but remain distinct from resident microglia in their transcriptome and gene accessibility landscape.https://doi.org/10.1038/s41467-018-07548-5 |
| spellingShingle | Anat Shemer Jonathan Grozovski Tuan Leng Tay Jenhan Tao Alon Volaski Patrick Süß Alberto Ardura-Fabregat Mor Gross-Vered Jung-Seok Kim Eyal David Louise Chappell-Maor Lars Thielecke Christopher K. Glass Kerstin Cornils Marco Prinz Steffen Jung Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge Nature Communications |
| title | Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge |
| title_full | Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge |
| title_fullStr | Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge |
| title_full_unstemmed | Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge |
| title_short | Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge |
| title_sort | engrafted parenchymal brain macrophages differ from microglia in transcriptome chromatin landscape and response to challenge |
| url | https://doi.org/10.1038/s41467-018-07548-5 |
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