The participation of nitric oxide the pathophysiology of chronic kidney disease
Nitric oxide (NO) is a free radical gas, inorganic, which has seven electrons of nitrogen and oxygen eight, possessing an unpaired electron. This radical is produced from L-arginine by a reaction mediated by the enzyme NO synthase. NO it is about a radical of who acts abundant on a variety of biolog...
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| Format: | Article |
| Language: | English |
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Universidade Estadual de Londrina
2014-10-01
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| Series: | Semina: Ciências Agrárias |
| Subjects: | |
| Online Access: | http://www.uel.br/revistas/uel/index.php/semagrarias/editor/submission/16049 |
| _version_ | 1818236942936965120 |
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| author | André Luiz Baptista Galvão Marileda Bonafim Carvalho |
| author_facet | André Luiz Baptista Galvão Marileda Bonafim Carvalho |
| author_sort | André Luiz Baptista Galvão |
| collection | DOAJ |
| description | Nitric oxide (NO) is a free radical gas, inorganic, which has seven electrons of nitrogen and oxygen eight, possessing an unpaired electron. This radical is produced from L-arginine by a reaction mediated by the enzyme NO synthase. NO it is about a radical of who acts abundant on a variety of biological processes, particularly when produced by endothelial cells plays a significant role in cardiovascular control, as a modulator of peripheral vascular resistance and platelet aggregation. This free radical has also a neurotransmitter and mediator of the immune system. NO kidney function has been considered in many physiological functions such as: (a) regulation of hemodynamics and glomerular function tubuloglomerular, (b) participation in pressure natriuresis (c) maintaining medullar perfusion (d) inhibiting sodium reabsorption tubular, and (e) acting as a modulator of the activity of the sympathetic nervous system. Given these functions, the occurrence of its deficiency is associated with chronic kidney disease (CKD) in vasoconstriction and consequently glomerular hypertension, high blood pressure (HBP), proteinuria and progression of renal dysfunction. This work has the scope to describe the role of NO in renal physiology and pathophysiology of CKD. |
| first_indexed | 2024-12-12T12:17:53Z |
| format | Article |
| id | doaj.art-9f2bcda04b4c4200b0e35f47030a2a35 |
| institution | Directory Open Access Journal |
| issn | 1676-546X 1679-0359 |
| language | English |
| last_indexed | 2024-12-12T12:17:53Z |
| publishDate | 2014-10-01 |
| publisher | Universidade Estadual de Londrina |
| record_format | Article |
| series | Semina: Ciências Agrárias |
| spelling | doaj.art-9f2bcda04b4c4200b0e35f47030a2a352022-12-22T00:24:43ZengUniversidade Estadual de LondrinaSemina: Ciências Agrárias1676-546X1679-03592014-10-013552625263410.5433/1679-0359.2014v35n5p2625The participation of nitric oxide the pathophysiology of chronic kidney disease André Luiz Baptista Galvão 0Marileda Bonafim Carvalho 1Centro Universitário de Rio PretoFaculdade de Ciências Agrárias e Medicina Veterinária/Universidade Estadual PaulistaNitric oxide (NO) is a free radical gas, inorganic, which has seven electrons of nitrogen and oxygen eight, possessing an unpaired electron. This radical is produced from L-arginine by a reaction mediated by the enzyme NO synthase. NO it is about a radical of who acts abundant on a variety of biological processes, particularly when produced by endothelial cells plays a significant role in cardiovascular control, as a modulator of peripheral vascular resistance and platelet aggregation. This free radical has also a neurotransmitter and mediator of the immune system. NO kidney function has been considered in many physiological functions such as: (a) regulation of hemodynamics and glomerular function tubuloglomerular, (b) participation in pressure natriuresis (c) maintaining medullar perfusion (d) inhibiting sodium reabsorption tubular, and (e) acting as a modulator of the activity of the sympathetic nervous system. Given these functions, the occurrence of its deficiency is associated with chronic kidney disease (CKD) in vasoconstriction and consequently glomerular hypertension, high blood pressure (HBP), proteinuria and progression of renal dysfunction. This work has the scope to describe the role of NO in renal physiology and pathophysiology of CKD.http://www.uel.br/revistas/uel/index.php/semagrarias/editor/submission/16049Creatinine; Hypertension; Proteinuria |
| spellingShingle | André Luiz Baptista Galvão Marileda Bonafim Carvalho The participation of nitric oxide the pathophysiology of chronic kidney disease Semina: Ciências Agrárias Creatinine; Hypertension; Proteinuria |
| title | The participation of nitric oxide the pathophysiology of chronic kidney disease |
| title_full | The participation of nitric oxide the pathophysiology of chronic kidney disease |
| title_fullStr | The participation of nitric oxide the pathophysiology of chronic kidney disease |
| title_full_unstemmed | The participation of nitric oxide the pathophysiology of chronic kidney disease |
| title_short | The participation of nitric oxide the pathophysiology of chronic kidney disease |
| title_sort | participation of nitric oxide the pathophysiology of chronic kidney disease |
| topic | Creatinine; Hypertension; Proteinuria |
| url | http://www.uel.br/revistas/uel/index.php/semagrarias/editor/submission/16049 |
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