Comparison of superb microvascular imaging and shear wave elastography for assessing liver fibrosis in chronic hepatitis B
Purpose The present study investigated the effectiveness and applicability of superb microvascular imaging (SMI) in determining the degree of liver fibrosis noninvasively in comparison with shear wave elastography (SWE). Methods Ninety-eight consecutive patients with chronic hepatitis B who underwen...
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| Format: | Article |
| Language: | English |
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Korean Society of Ultrasound in Medicine
2022-04-01
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| Series: | Ultrasonography |
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| Online Access: | http://www.e-ultrasonography.org/upload/usg-21136.pdf |
| _version_ | 1818314504744730624 |
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| author | Mesude Tosun Hande Uslu |
| author_facet | Mesude Tosun Hande Uslu |
| author_sort | Mesude Tosun |
| collection | DOAJ |
| description | Purpose The present study investigated the effectiveness and applicability of superb microvascular imaging (SMI) in determining the degree of liver fibrosis noninvasively in comparison with shear wave elastography (SWE). Methods Ninety-eight consecutive patients with chronic hepatitis B who underwent ultrasound (US)-guided needle biopsy were examined using US combined with SMI and SWE. The predictive performance of the two US techniques in staging liver fibrosis and inflammation was compared with reference to the histological findings obtained from liver biopsy. The intraobserver and interobserver reproducibility of SMI in vascularity scores were evaluated. Results SWE values and SMI vascular scores were statistically significantly different among fibrosis stages (χ2(3)=76.3, χ2(3)=81.5, P<0.001). The SWE and SMI models significantly predicted fibrosis stages separately, and SMI scores alone predicted fibrosis stages better than SWE values (50.1% for SWE, 63.5% for SMI, P<0.001). A model with both SMI scores and SWE values together explained 73.2% of variance in fibrosis stages. When other clinical and laboratory predictors were added to the model (81.5%, P<0.001), SWE values and SMI scores remained the main predictors of fibrosis stages. SWE and SMI were also applicable in predicting inflammatory grades, explaining 31% and 34% of variance, respectively, and 37.7% when used together (P<0.001). Conclusion Both SWE and SMI had good diagnostic performance in determining the degree of liver fibrosis in chronic hepatitis B patients. The efficacy of SMI was better than that of SWE. SMI can improve diagnostic performance for staging liver fibrosis and shows potential for estimating necroinflammation of the liver. |
| first_indexed | 2024-12-13T08:50:42Z |
| format | Article |
| id | doaj.art-9f2ed02b66184eed9e52189bbfc5a726 |
| institution | Directory Open Access Journal |
| issn | 2288-5919 2288-5943 |
| language | English |
| last_indexed | 2024-12-13T08:50:42Z |
| publishDate | 2022-04-01 |
| publisher | Korean Society of Ultrasound in Medicine |
| record_format | Article |
| series | Ultrasonography |
| spelling | doaj.art-9f2ed02b66184eed9e52189bbfc5a7262022-12-21T23:53:22ZengKorean Society of Ultrasound in MedicineUltrasonography2288-59192288-59432022-04-0141239440210.14366/usg.211361586Comparison of superb microvascular imaging and shear wave elastography for assessing liver fibrosis in chronic hepatitis BMesude Tosun0Hande Uslu1 Department of Radiology, Kocaeli University School of Medicine, Kocaeli, Turkey Department of Radiology, Kocaeli University School of Medicine, Kocaeli, TurkeyPurpose The present study investigated the effectiveness and applicability of superb microvascular imaging (SMI) in determining the degree of liver fibrosis noninvasively in comparison with shear wave elastography (SWE). Methods Ninety-eight consecutive patients with chronic hepatitis B who underwent ultrasound (US)-guided needle biopsy were examined using US combined with SMI and SWE. The predictive performance of the two US techniques in staging liver fibrosis and inflammation was compared with reference to the histological findings obtained from liver biopsy. The intraobserver and interobserver reproducibility of SMI in vascularity scores were evaluated. Results SWE values and SMI vascular scores were statistically significantly different among fibrosis stages (χ2(3)=76.3, χ2(3)=81.5, P<0.001). The SWE and SMI models significantly predicted fibrosis stages separately, and SMI scores alone predicted fibrosis stages better than SWE values (50.1% for SWE, 63.5% for SMI, P<0.001). A model with both SMI scores and SWE values together explained 73.2% of variance in fibrosis stages. When other clinical and laboratory predictors were added to the model (81.5%, P<0.001), SWE values and SMI scores remained the main predictors of fibrosis stages. SWE and SMI were also applicable in predicting inflammatory grades, explaining 31% and 34% of variance, respectively, and 37.7% when used together (P<0.001). Conclusion Both SWE and SMI had good diagnostic performance in determining the degree of liver fibrosis in chronic hepatitis B patients. The efficacy of SMI was better than that of SWE. SMI can improve diagnostic performance for staging liver fibrosis and shows potential for estimating necroinflammation of the liver.http://www.e-ultrasonography.org/upload/usg-21136.pdfliver cirrhosisshear wave us elastographysuperb microvascular imagingvascularity scorechronic hepatitis binflammation |
| spellingShingle | Mesude Tosun Hande Uslu Comparison of superb microvascular imaging and shear wave elastography for assessing liver fibrosis in chronic hepatitis B Ultrasonography liver cirrhosis shear wave us elastography superb microvascular imaging vascularity score chronic hepatitis b inflammation |
| title | Comparison of superb microvascular imaging and shear wave elastography for assessing liver fibrosis in chronic hepatitis B |
| title_full | Comparison of superb microvascular imaging and shear wave elastography for assessing liver fibrosis in chronic hepatitis B |
| title_fullStr | Comparison of superb microvascular imaging and shear wave elastography for assessing liver fibrosis in chronic hepatitis B |
| title_full_unstemmed | Comparison of superb microvascular imaging and shear wave elastography for assessing liver fibrosis in chronic hepatitis B |
| title_short | Comparison of superb microvascular imaging and shear wave elastography for assessing liver fibrosis in chronic hepatitis B |
| title_sort | comparison of superb microvascular imaging and shear wave elastography for assessing liver fibrosis in chronic hepatitis b |
| topic | liver cirrhosis shear wave us elastography superb microvascular imaging vascularity score chronic hepatitis b inflammation |
| url | http://www.e-ultrasonography.org/upload/usg-21136.pdf |
| work_keys_str_mv | AT mesudetosun comparisonofsuperbmicrovascularimagingandshearwaveelastographyforassessingliverfibrosisinchronichepatitisb AT handeuslu comparisonofsuperbmicrovascularimagingandshearwaveelastographyforassessingliverfibrosisinchronichepatitisb |