In Vitro Toxicity testing in the 21st Century
The National Research Council (NRC) article Toxicity Testing in the 21st Century: A vision and A Strategy (National Research Council, 2007) was written to bring attention to the application of scientific advances for use in toxicity tests so that chemicals can be tested in a more time and cost effic...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2011-02-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphar.2011.00003/full |
| _version_ | 1811257157297897472 |
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| author | Erwin L Roggen |
| author_facet | Erwin L Roggen |
| author_sort | Erwin L Roggen |
| collection | DOAJ |
| description | The National Research Council (NRC) article Toxicity Testing in the 21st Century: A vision and A Strategy (National Research Council, 2007) was written to bring attention to the application of scientific advances for use in toxicity tests so that chemicals can be tested in a more time and cost efficient manner while providing a more relevant and mechanistic insight into the toxic potential of a compound.Development of tools for in vitro toxicity testing constitutes an important activity of this vision and contributes to the provision of test systems as well as data that are essential for the development of computer modelling tools for e.g. system biology, physiologically-based modelling. This article intends to highlight some of the issues that have to be addressed in order to make in vitro toxicity testing a reality in the 21st century. |
| first_indexed | 2024-04-12T17:52:57Z |
| format | Article |
| id | doaj.art-9f2f91aa887c4455abb2c12241accb14 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-12T17:52:57Z |
| publishDate | 2011-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-9f2f91aa887c4455abb2c12241accb142022-12-22T03:22:27ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122011-02-01210.3389/fphar.2011.000032042In Vitro Toxicity testing in the 21st CenturyErwin L Roggen0Novozymes ASThe National Research Council (NRC) article Toxicity Testing in the 21st Century: A vision and A Strategy (National Research Council, 2007) was written to bring attention to the application of scientific advances for use in toxicity tests so that chemicals can be tested in a more time and cost efficient manner while providing a more relevant and mechanistic insight into the toxic potential of a compound.Development of tools for in vitro toxicity testing constitutes an important activity of this vision and contributes to the provision of test systems as well as data that are essential for the development of computer modelling tools for e.g. system biology, physiologically-based modelling. This article intends to highlight some of the issues that have to be addressed in order to make in vitro toxicity testing a reality in the 21st century.http://journal.frontiersin.org/Journal/10.3389/fphar.2011.00003/fullValidationIn vitro toxicologyadaptive responsesadverse responseshuman-specific methodsintegrated tersting strategies |
| spellingShingle | Erwin L Roggen In Vitro Toxicity testing in the 21st Century Frontiers in Pharmacology Validation In vitro toxicology adaptive responses adverse responses human-specific methods integrated tersting strategies |
| title | In Vitro Toxicity testing in the 21st Century |
| title_full | In Vitro Toxicity testing in the 21st Century |
| title_fullStr | In Vitro Toxicity testing in the 21st Century |
| title_full_unstemmed | In Vitro Toxicity testing in the 21st Century |
| title_short | In Vitro Toxicity testing in the 21st Century |
| title_sort | in vitro toxicity testing in the 21st century |
| topic | Validation In vitro toxicology adaptive responses adverse responses human-specific methods integrated tersting strategies |
| url | http://journal.frontiersin.org/Journal/10.3389/fphar.2011.00003/full |
| work_keys_str_mv | AT erwinlroggen invitrotoxicitytestinginthe21stcentury |