Pancreatic Proteolytic Enzymes and Cancer: New Support for an Old Theory
In 1905, the embryologist John Beard first proposed that pancreatic proteolytic enzymes had potential as a treatment for cancer. His theories were dismissed by the medical world a decade later, but various practitioners have kept the concept alive through the publication of case reports of cancer pa...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2022-05-01
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| Series: | Integrative Cancer Therapies |
| Online Access: | https://doi.org/10.1177/15347354221096077 |
| _version_ | 1811338602055991296 |
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| author | Linda L. Isaacs MD |
| author_facet | Linda L. Isaacs MD |
| author_sort | Linda L. Isaacs MD |
| collection | DOAJ |
| description | In 1905, the embryologist John Beard first proposed that pancreatic proteolytic enzymes had potential as a treatment for cancer. His theories were dismissed by the medical world a decade later, but various practitioners have kept the concept alive through the publication of case reports of cancer patients treated with pancreatic proteolytic enzymes. In the last 2 decades, studies of the role of proteases in physiology have made it clear that they do more than digest food. This article reviews the history of the clinical use of pancreatic proteolytic enzymes in cancer treatment, and recent research on protease activated receptors and their role in cancer. |
| first_indexed | 2024-04-13T18:13:31Z |
| format | Article |
| id | doaj.art-9f2fabc4798c4c7e93374bcd24788028 |
| institution | Directory Open Access Journal |
| issn | 1534-7354 1552-695X |
| language | English |
| last_indexed | 2024-04-13T18:13:31Z |
| publishDate | 2022-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Integrative Cancer Therapies |
| spelling | doaj.art-9f2fabc4798c4c7e93374bcd247880282022-12-22T02:35:49ZengSAGE PublishingIntegrative Cancer Therapies1534-73541552-695X2022-05-012110.1177/15347354221096077Pancreatic Proteolytic Enzymes and Cancer: New Support for an Old TheoryLinda L. Isaacs MD0Private Practice, Austin, TX, USAIn 1905, the embryologist John Beard first proposed that pancreatic proteolytic enzymes had potential as a treatment for cancer. His theories were dismissed by the medical world a decade later, but various practitioners have kept the concept alive through the publication of case reports of cancer patients treated with pancreatic proteolytic enzymes. In the last 2 decades, studies of the role of proteases in physiology have made it clear that they do more than digest food. This article reviews the history of the clinical use of pancreatic proteolytic enzymes in cancer treatment, and recent research on protease activated receptors and their role in cancer.https://doi.org/10.1177/15347354221096077 |
| spellingShingle | Linda L. Isaacs MD Pancreatic Proteolytic Enzymes and Cancer: New Support for an Old Theory Integrative Cancer Therapies |
| title | Pancreatic Proteolytic Enzymes and Cancer: New Support for an Old Theory |
| title_full | Pancreatic Proteolytic Enzymes and Cancer: New Support for an Old Theory |
| title_fullStr | Pancreatic Proteolytic Enzymes and Cancer: New Support for an Old Theory |
| title_full_unstemmed | Pancreatic Proteolytic Enzymes and Cancer: New Support for an Old Theory |
| title_short | Pancreatic Proteolytic Enzymes and Cancer: New Support for an Old Theory |
| title_sort | pancreatic proteolytic enzymes and cancer new support for an old theory |
| url | https://doi.org/10.1177/15347354221096077 |
| work_keys_str_mv | AT lindalisaacsmd pancreaticproteolyticenzymesandcancernewsupportforanoldtheory |