Effects of Fucoidan Powder Combined with Mineral Trioxide Aggregate as a Direct Pulp-Capping Material
The development of direct pulp-capping materials with favorable biological and structural properties is an important goal in restorative dentistry. Fucoidan is a sulfated, fucose-containing polysaccharide obtained from brown seaweed, with a wide range of applications; however, its use as a direct pu...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/14/12/2315 |
| _version_ | 1797483080697511936 |
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| author | Mijoo Kim Marc Hayashi Bo Yu Thomas K. Lee Reuben H. Kim Deuk-Won Jo |
| author_facet | Mijoo Kim Marc Hayashi Bo Yu Thomas K. Lee Reuben H. Kim Deuk-Won Jo |
| author_sort | Mijoo Kim |
| collection | DOAJ |
| description | The development of direct pulp-capping materials with favorable biological and structural properties is an important goal in restorative dentistry. Fucoidan is a sulfated, fucose-containing polysaccharide obtained from brown seaweed, with a wide range of applications; however, its use as a direct pulp-capping material has not been examined. This study aimed to evaluate the mechanical, physical, and biological effects of fucoidan combined with conventional mineral trioxide aggregate (MTA) for direct pulp capping. The capping materials were created using Portland cement (80 wt%) and zirconium oxide (20 wt%) as base components, compared with base components plus 5 wt% fucoidan (PZF5) and base components plus 10 wt% fucoidan (PZF10). The initial and final setting time, compressive strength, chemical components, cell viability, adhesion, migration, osteogenesis, and gene expression were analyzed. Fucoidan significantly reduced the initial and final setting time, regardless of quantity. However, the compressive strength was lower for PZF5. Sulfur levels increased with fucoidan. The biological activity improved, especially in the PZF5 group. Cell migration, Alizarin Red S staining, and alkaline phosphatase activity were upregulated in the PZF5 group. Fucoidan is a useful regenerative additive for conventional pulp-capping materials because it reduces the setting time and improves cell migration and osteogenic ability. |
| first_indexed | 2024-03-09T22:42:44Z |
| format | Article |
| id | doaj.art-9f2fd941449b41bab3315cf6633fd6e8 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-09T22:42:44Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-9f2fd941449b41bab3315cf6633fd6e82023-11-23T18:35:55ZengMDPI AGPolymers2073-43602022-06-011412231510.3390/polym14122315Effects of Fucoidan Powder Combined with Mineral Trioxide Aggregate as a Direct Pulp-Capping MaterialMijoo Kim0Marc Hayashi1Bo Yu2Thomas K. Lee3Reuben H. Kim4Deuk-Won Jo5UCLA School of Dentistry Restorative Materials and Applied Dental Research Laboratory, Los Angeles, CA 90095, USAUCLA School of Dentistry Restorative Materials and Applied Dental Research Laboratory, Los Angeles, CA 90095, USAUCLA School of Dentistry Restorative Materials and Applied Dental Research Laboratory, Los Angeles, CA 90095, USAUCLA School of Dentistry Restorative Materials and Applied Dental Research Laboratory, Los Angeles, CA 90095, USAUCLA School of Dentistry Restorative Materials and Applied Dental Research Laboratory, Los Angeles, CA 90095, USASection of Dentistry, Department of Prosthodontics, Seoul National University Bundang Hospital, Seongnam 13620, KoreaThe development of direct pulp-capping materials with favorable biological and structural properties is an important goal in restorative dentistry. Fucoidan is a sulfated, fucose-containing polysaccharide obtained from brown seaweed, with a wide range of applications; however, its use as a direct pulp-capping material has not been examined. This study aimed to evaluate the mechanical, physical, and biological effects of fucoidan combined with conventional mineral trioxide aggregate (MTA) for direct pulp capping. The capping materials were created using Portland cement (80 wt%) and zirconium oxide (20 wt%) as base components, compared with base components plus 5 wt% fucoidan (PZF5) and base components plus 10 wt% fucoidan (PZF10). The initial and final setting time, compressive strength, chemical components, cell viability, adhesion, migration, osteogenesis, and gene expression were analyzed. Fucoidan significantly reduced the initial and final setting time, regardless of quantity. However, the compressive strength was lower for PZF5. Sulfur levels increased with fucoidan. The biological activity improved, especially in the PZF5 group. Cell migration, Alizarin Red S staining, and alkaline phosphatase activity were upregulated in the PZF5 group. Fucoidan is a useful regenerative additive for conventional pulp-capping materials because it reduces the setting time and improves cell migration and osteogenic ability.https://www.mdpi.com/2073-4360/14/12/2315direct pulp cappingfucoidanmineral trioxide aggregateosteogenesisportland cementtooth regeneration |
| spellingShingle | Mijoo Kim Marc Hayashi Bo Yu Thomas K. Lee Reuben H. Kim Deuk-Won Jo Effects of Fucoidan Powder Combined with Mineral Trioxide Aggregate as a Direct Pulp-Capping Material Polymers direct pulp capping fucoidan mineral trioxide aggregate osteogenesis portland cement tooth regeneration |
| title | Effects of Fucoidan Powder Combined with Mineral Trioxide Aggregate as a Direct Pulp-Capping Material |
| title_full | Effects of Fucoidan Powder Combined with Mineral Trioxide Aggregate as a Direct Pulp-Capping Material |
| title_fullStr | Effects of Fucoidan Powder Combined with Mineral Trioxide Aggregate as a Direct Pulp-Capping Material |
| title_full_unstemmed | Effects of Fucoidan Powder Combined with Mineral Trioxide Aggregate as a Direct Pulp-Capping Material |
| title_short | Effects of Fucoidan Powder Combined with Mineral Trioxide Aggregate as a Direct Pulp-Capping Material |
| title_sort | effects of fucoidan powder combined with mineral trioxide aggregate as a direct pulp capping material |
| topic | direct pulp capping fucoidan mineral trioxide aggregate osteogenesis portland cement tooth regeneration |
| url | https://www.mdpi.com/2073-4360/14/12/2315 |
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