Nanoparticles Stokes radius assessment through permeability coefficient determination within a new stratified epithelium on-chip model
AbstractTissue barrier permeability plays a crucial role in determining the selective transport of substances across epithelial tissues, including drugs, cosmetic substances, and chemicals. The ability of these substances to cross through tissue barriers affects their absorption into the bloodstream...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Artificial Cells, Nanomedicine, and Biotechnology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21691401.2023.2253534 |
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| author | E. Fernandez-Carro R. Salomon-Cambero L. Armero H. A. Castro-Abril J. Ayensa-Jiménez Miguel A. Martínez I. Ochoa C. Alcaine I. García J. Ciriza |
| author_facet | E. Fernandez-Carro R. Salomon-Cambero L. Armero H. A. Castro-Abril J. Ayensa-Jiménez Miguel A. Martínez I. Ochoa C. Alcaine I. García J. Ciriza |
| author_sort | E. Fernandez-Carro |
| collection | DOAJ |
| description | AbstractTissue barrier permeability plays a crucial role in determining the selective transport of substances across epithelial tissues, including drugs, cosmetic substances, and chemicals. The ability of these substances to cross through tissue barriers affects their absorption into the bloodstream and ultimately their effectiveness. Therefore, the determination of their permeability on these type of tissue barriers represents a useful tool for pharmaceutical and cosmetic industries as well as for toxicological studies.In this regard, microfluidic devices and organ-on-chip technologies are becoming more important to generate reliable data. We have designed and performed an alternative new stratified epithelia-on-chip model that allows to correlate the Stokes radius and the diffusion of molecules and/or nanoformulations through the in vitro generated barrier and establish a system suitable for the analysis of diffusion through stratified epithelium. Thus, extrapolating from experimental data we can predict the Stokes radius for unknown fluorescent labelled particles within a molecular size range, such as gold nanoparticles. |
| first_indexed | 2024-03-09T10:51:38Z |
| format | Article |
| id | doaj.art-9f3082180c794d64af7d026cd5b05bd8 |
| institution | Directory Open Access Journal |
| issn | 2169-1401 2169-141X |
| language | English |
| last_indexed | 2024-03-09T10:51:38Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Artificial Cells, Nanomedicine, and Biotechnology |
| spelling | doaj.art-9f3082180c794d64af7d026cd5b05bd82023-12-01T06:41:40ZengTaylor & Francis GroupArtificial Cells, Nanomedicine, and Biotechnology2169-14012169-141X2023-12-0151146647510.1080/21691401.2023.2253534Nanoparticles Stokes radius assessment through permeability coefficient determination within a new stratified epithelium on-chip modelE. Fernandez-Carro0R. Salomon-Cambero1L. Armero2H. A. Castro-Abril3J. Ayensa-Jiménez4Miguel A. Martínez5I. Ochoa6C. Alcaine7I. García8J. Ciriza9Tissue Microenvironment (TME) Lab. Aragón Institute of Engineering Research (I3A), University of Zaragoza, Zaragoza, SpainTissue Microenvironment (TME) Lab. Aragón Institute of Engineering Research (I3A), University of Zaragoza, Zaragoza, SpainCenter for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Donostia-San Sebastián, SpainTissue Microenvironment (TME) Lab. Aragón Institute of Engineering Research (I3A), University of Zaragoza, Zaragoza, SpainTissue Microenvironment (TME) Lab. Aragón Institute of Engineering Research (I3A), University of Zaragoza, Zaragoza, SpainTissue Microenvironment (TME) Lab. Aragón Institute of Engineering Research (I3A), University of Zaragoza, Zaragoza, SpainTissue Microenvironment (TME) Lab. Aragón Institute of Engineering Research (I3A), University of Zaragoza, Zaragoza, SpainTissue Microenvironment (TME) Lab. Aragón Institute of Engineering Research (I3A), University of Zaragoza, Zaragoza, SpainCenter for Cooperative Research in Biomaterials (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), Donostia-San Sebastián, SpainTissue Microenvironment (TME) Lab. Aragón Institute of Engineering Research (I3A), University of Zaragoza, Zaragoza, SpainAbstractTissue barrier permeability plays a crucial role in determining the selective transport of substances across epithelial tissues, including drugs, cosmetic substances, and chemicals. The ability of these substances to cross through tissue barriers affects their absorption into the bloodstream and ultimately their effectiveness. Therefore, the determination of their permeability on these type of tissue barriers represents a useful tool for pharmaceutical and cosmetic industries as well as for toxicological studies.In this regard, microfluidic devices and organ-on-chip technologies are becoming more important to generate reliable data. We have designed and performed an alternative new stratified epithelia-on-chip model that allows to correlate the Stokes radius and the diffusion of molecules and/or nanoformulations through the in vitro generated barrier and establish a system suitable for the analysis of diffusion through stratified epithelium. Thus, extrapolating from experimental data we can predict the Stokes radius for unknown fluorescent labelled particles within a molecular size range, such as gold nanoparticles.https://www.tandfonline.com/doi/10.1080/21691401.2023.2253534Skin on chipmicrofluidic devicespermeabilitystokes radiusnanoparticles |
| spellingShingle | E. Fernandez-Carro R. Salomon-Cambero L. Armero H. A. Castro-Abril J. Ayensa-Jiménez Miguel A. Martínez I. Ochoa C. Alcaine I. García J. Ciriza Nanoparticles Stokes radius assessment through permeability coefficient determination within a new stratified epithelium on-chip model Artificial Cells, Nanomedicine, and Biotechnology Skin on chip microfluidic devices permeability stokes radius nanoparticles |
| title | Nanoparticles Stokes radius assessment through permeability coefficient determination within a new stratified epithelium on-chip model |
| title_full | Nanoparticles Stokes radius assessment through permeability coefficient determination within a new stratified epithelium on-chip model |
| title_fullStr | Nanoparticles Stokes radius assessment through permeability coefficient determination within a new stratified epithelium on-chip model |
| title_full_unstemmed | Nanoparticles Stokes radius assessment through permeability coefficient determination within a new stratified epithelium on-chip model |
| title_short | Nanoparticles Stokes radius assessment through permeability coefficient determination within a new stratified epithelium on-chip model |
| title_sort | nanoparticles stokes radius assessment through permeability coefficient determination within a new stratified epithelium on chip model |
| topic | Skin on chip microfluidic devices permeability stokes radius nanoparticles |
| url | https://www.tandfonline.com/doi/10.1080/21691401.2023.2253534 |
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