Comparison of cardiovascular event predictability between the 2009 and 2021 Chronic Kidney Disease Epidemiology Collaboration equations in a Korean chronic kidney disease cohort: the KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease study
Background The 2009 Chronic Kidney Disease Epidemiology Collaboration creatinine-based estimated glomerular filtration rate (eGFRcr) equation contains a race component that is not based on biology and may cause a bias in results. Therefore, the 2021 eGFRcr and creatinine-cystatin C–based eGFR (eGFRc...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
The Korean Society of Nephrology
2023-11-01
|
| Series: | Kidney Research and Clinical Practice |
| Subjects: | |
| Online Access: | http://krcp-ksn.org/upload/pdf/j-krcp-22-206.pdf |
| _version_ | 1797311460708188160 |
|---|---|
| author | Ji Hye Kim Minjung Kang Eunjeong Kang Hyunjin Ryu Yujin Jeong Jayoun Kim Sue K. Park Jong Cheol Jeong Tae-Hyun Yoo Yaeni Kim Yong Chul Kim Seung Seok Han Hajeong Lee Kook-Hwan Oh |
| author_facet | Ji Hye Kim Minjung Kang Eunjeong Kang Hyunjin Ryu Yujin Jeong Jayoun Kim Sue K. Park Jong Cheol Jeong Tae-Hyun Yoo Yaeni Kim Yong Chul Kim Seung Seok Han Hajeong Lee Kook-Hwan Oh |
| author_sort | Ji Hye Kim |
| collection | DOAJ |
| description | Background The 2009 Chronic Kidney Disease Epidemiology Collaboration creatinine-based estimated glomerular filtration rate (eGFRcr) equation contains a race component that is not based on biology and may cause a bias in results. Therefore, the 2021 eGFRcr and creatinine-cystatin C–based eGFR (eGFRcr-cysC) equations were developed with no consideration of race. This study compared the cardiovascular event (CVE) and all-cause mortality and CVE combined predictability among the three eGFR equations in Korean chronic kidney disease (CKD) patients. Methods This study included 2,207 patients from the KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease. Receiver operating characteristic (ROC) and net reclassification improvement (NRI) index were used to compare the predictability of the study outcomes according to the 2009 eGFRcr, 2021 eGFRcr, and 2021 eGFRcr-cysC equations. Results The overall prevalence of CVE and all-cause mortality were 9% and 7%, respectively. There was no difference in area under the curve of ROC for CVE and mortality and CVE combined among all three equations. Compared to the 2009 eGFRcr, both the 2021 eGFRcr (NRI, 0.013; 95% confidence interval [CI], –0.002 to 0.028) and the eGFRcr-cysC (NRI, –0.001; 95% CI, –0.031 to 0.029) equations did not show improved CVE predictability. Similar findings were observed for mortality and CVE combined predictability with both the 2021 eGFRcr (NRI, –0.019; 95% CI, –0.039–0.000) and the eGFRcr-cysC (NRI, –0.002; 95% CI, –0.023 to 0.018). Conclusion The 2009 eGFRcr equation was not inferior to either the 2021 eGFRcr or eGFRcr-cysC equation in predicting CVE and the composite of mortality and CVE in Korean CKD patients. |
| first_indexed | 2024-03-08T02:00:01Z |
| format | Article |
| id | doaj.art-9f30992db6a6420e890df06876d70a0b |
| institution | Directory Open Access Journal |
| issn | 2211-9132 2211-9140 |
| language | English |
| last_indexed | 2024-03-08T02:00:01Z |
| publishDate | 2023-11-01 |
| publisher | The Korean Society of Nephrology |
| record_format | Article |
| series | Kidney Research and Clinical Practice |
| spelling | doaj.art-9f30992db6a6420e890df06876d70a0b2024-02-14T06:27:47ZengThe Korean Society of NephrologyKidney Research and Clinical Practice2211-91322211-91402023-11-0142670071110.23876/j.krcp.22.2066198Comparison of cardiovascular event predictability between the 2009 and 2021 Chronic Kidney Disease Epidemiology Collaboration equations in a Korean chronic kidney disease cohort: the KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease studyJi Hye Kim0Minjung Kang1Eunjeong Kang2Hyunjin Ryu3Yujin Jeong4Jayoun Kim5Sue K. Park6Jong Cheol Jeong7Tae-Hyun Yoo8Yaeni Kim9Yong Chul Kim10Seung Seok Han11Hajeong Lee12Kook-Hwan Oh13 Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea Department of Internal Medicine, Ewha Womans University College of Medicine, Ewha Womans University Seoul Hospital, Seoul, Republic of Korea Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea Department of Biostatistics, Korea University College of Medicine, Seoul, Republic of Korea Medical Research Collaborating Center, Seoul National University Hospital, Seoul, Republic of Korea Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of KoreaBackground The 2009 Chronic Kidney Disease Epidemiology Collaboration creatinine-based estimated glomerular filtration rate (eGFRcr) equation contains a race component that is not based on biology and may cause a bias in results. Therefore, the 2021 eGFRcr and creatinine-cystatin C–based eGFR (eGFRcr-cysC) equations were developed with no consideration of race. This study compared the cardiovascular event (CVE) and all-cause mortality and CVE combined predictability among the three eGFR equations in Korean chronic kidney disease (CKD) patients. Methods This study included 2,207 patients from the KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease. Receiver operating characteristic (ROC) and net reclassification improvement (NRI) index were used to compare the predictability of the study outcomes according to the 2009 eGFRcr, 2021 eGFRcr, and 2021 eGFRcr-cysC equations. Results The overall prevalence of CVE and all-cause mortality were 9% and 7%, respectively. There was no difference in area under the curve of ROC for CVE and mortality and CVE combined among all three equations. Compared to the 2009 eGFRcr, both the 2021 eGFRcr (NRI, 0.013; 95% confidence interval [CI], –0.002 to 0.028) and the eGFRcr-cysC (NRI, –0.001; 95% CI, –0.031 to 0.029) equations did not show improved CVE predictability. Similar findings were observed for mortality and CVE combined predictability with both the 2021 eGFRcr (NRI, –0.019; 95% CI, –0.039–0.000) and the eGFRcr-cysC (NRI, –0.002; 95% CI, –0.023 to 0.018). Conclusion The 2009 eGFRcr equation was not inferior to either the 2021 eGFRcr or eGFRcr-cysC equation in predicting CVE and the composite of mortality and CVE in Korean CKD patients.http://krcp-ksn.org/upload/pdf/j-krcp-22-206.pdfcardiovascular diseaseschronic renal insufficiencycreatininecystatin cracial groups |
| spellingShingle | Ji Hye Kim Minjung Kang Eunjeong Kang Hyunjin Ryu Yujin Jeong Jayoun Kim Sue K. Park Jong Cheol Jeong Tae-Hyun Yoo Yaeni Kim Yong Chul Kim Seung Seok Han Hajeong Lee Kook-Hwan Oh Comparison of cardiovascular event predictability between the 2009 and 2021 Chronic Kidney Disease Epidemiology Collaboration equations in a Korean chronic kidney disease cohort: the KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease study Kidney Research and Clinical Practice cardiovascular diseases chronic renal insufficiency creatinine cystatin c racial groups |
| title | Comparison of cardiovascular event predictability between the 2009 and 2021 Chronic Kidney Disease Epidemiology Collaboration equations in a Korean chronic kidney disease cohort: the KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease study |
| title_full | Comparison of cardiovascular event predictability between the 2009 and 2021 Chronic Kidney Disease Epidemiology Collaboration equations in a Korean chronic kidney disease cohort: the KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease study |
| title_fullStr | Comparison of cardiovascular event predictability between the 2009 and 2021 Chronic Kidney Disease Epidemiology Collaboration equations in a Korean chronic kidney disease cohort: the KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease study |
| title_full_unstemmed | Comparison of cardiovascular event predictability between the 2009 and 2021 Chronic Kidney Disease Epidemiology Collaboration equations in a Korean chronic kidney disease cohort: the KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease study |
| title_short | Comparison of cardiovascular event predictability between the 2009 and 2021 Chronic Kidney Disease Epidemiology Collaboration equations in a Korean chronic kidney disease cohort: the KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease study |
| title_sort | comparison of cardiovascular event predictability between the 2009 and 2021 chronic kidney disease epidemiology collaboration equations in a korean chronic kidney disease cohort the korean cohort study for outcome in patients with chronic kidney disease study |
| topic | cardiovascular diseases chronic renal insufficiency creatinine cystatin c racial groups |
| url | http://krcp-ksn.org/upload/pdf/j-krcp-22-206.pdf |
| work_keys_str_mv | AT jihyekim comparisonofcardiovasculareventpredictabilitybetweenthe2009and2021chronickidneydiseaseepidemiologycollaborationequationsinakoreanchronickidneydiseasecohortthekoreancohortstudyforoutcomeinpatientswithchronickidneydiseasestudy AT minjungkang comparisonofcardiovasculareventpredictabilitybetweenthe2009and2021chronickidneydiseaseepidemiologycollaborationequationsinakoreanchronickidneydiseasecohortthekoreancohortstudyforoutcomeinpatientswithchronickidneydiseasestudy AT eunjeongkang comparisonofcardiovasculareventpredictabilitybetweenthe2009and2021chronickidneydiseaseepidemiologycollaborationequationsinakoreanchronickidneydiseasecohortthekoreancohortstudyforoutcomeinpatientswithchronickidneydiseasestudy AT hyunjinryu comparisonofcardiovasculareventpredictabilitybetweenthe2009and2021chronickidneydiseaseepidemiologycollaborationequationsinakoreanchronickidneydiseasecohortthekoreancohortstudyforoutcomeinpatientswithchronickidneydiseasestudy AT yujinjeong comparisonofcardiovasculareventpredictabilitybetweenthe2009and2021chronickidneydiseaseepidemiologycollaborationequationsinakoreanchronickidneydiseasecohortthekoreancohortstudyforoutcomeinpatientswithchronickidneydiseasestudy AT jayounkim comparisonofcardiovasculareventpredictabilitybetweenthe2009and2021chronickidneydiseaseepidemiologycollaborationequationsinakoreanchronickidneydiseasecohortthekoreancohortstudyforoutcomeinpatientswithchronickidneydiseasestudy AT suekpark comparisonofcardiovasculareventpredictabilitybetweenthe2009and2021chronickidneydiseaseepidemiologycollaborationequationsinakoreanchronickidneydiseasecohortthekoreancohortstudyforoutcomeinpatientswithchronickidneydiseasestudy AT jongcheoljeong comparisonofcardiovasculareventpredictabilitybetweenthe2009and2021chronickidneydiseaseepidemiologycollaborationequationsinakoreanchronickidneydiseasecohortthekoreancohortstudyforoutcomeinpatientswithchronickidneydiseasestudy AT taehyunyoo comparisonofcardiovasculareventpredictabilitybetweenthe2009and2021chronickidneydiseaseepidemiologycollaborationequationsinakoreanchronickidneydiseasecohortthekoreancohortstudyforoutcomeinpatientswithchronickidneydiseasestudy AT yaenikim comparisonofcardiovasculareventpredictabilitybetweenthe2009and2021chronickidneydiseaseepidemiologycollaborationequationsinakoreanchronickidneydiseasecohortthekoreancohortstudyforoutcomeinpatientswithchronickidneydiseasestudy AT yongchulkim comparisonofcardiovasculareventpredictabilitybetweenthe2009and2021chronickidneydiseaseepidemiologycollaborationequationsinakoreanchronickidneydiseasecohortthekoreancohortstudyforoutcomeinpatientswithchronickidneydiseasestudy AT seungseokhan comparisonofcardiovasculareventpredictabilitybetweenthe2009and2021chronickidneydiseaseepidemiologycollaborationequationsinakoreanchronickidneydiseasecohortthekoreancohortstudyforoutcomeinpatientswithchronickidneydiseasestudy AT hajeonglee comparisonofcardiovasculareventpredictabilitybetweenthe2009and2021chronickidneydiseaseepidemiologycollaborationequationsinakoreanchronickidneydiseasecohortthekoreancohortstudyforoutcomeinpatientswithchronickidneydiseasestudy AT kookhwanoh comparisonofcardiovasculareventpredictabilitybetweenthe2009and2021chronickidneydiseaseepidemiologycollaborationequationsinakoreanchronickidneydiseasecohortthekoreancohortstudyforoutcomeinpatientswithchronickidneydiseasestudy |