Macular perfusion normative data acquired with optical coherence tomography angiography in healthy four-year-old Caucasian children
Abstract Background The purpose of this cross-sectional study involving healthy emmetropic four-year-old Caucasian children was to provide a macular perfusion normative database acquired with optical coherence tomography angiography (OCTA). One eye of each examinee underwent OCTA imaging. The follow...
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| Format: | Article |
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BMC
2021-10-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-021-02122-y |
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| author | Dunja Bajtl Mirjana Bjeloš Mladen Bušić Ana Križanović Leon Marković Biljana Kuzmanović Elabjer |
| author_facet | Dunja Bajtl Mirjana Bjeloš Mladen Bušić Ana Križanović Leon Marković Biljana Kuzmanović Elabjer |
| author_sort | Dunja Bajtl |
| collection | DOAJ |
| description | Abstract Background The purpose of this cross-sectional study involving healthy emmetropic four-year-old Caucasian children was to provide a macular perfusion normative database acquired with optical coherence tomography angiography (OCTA). One eye of each examinee underwent OCTA imaging. The following parameters were analyzed using AngioTool Image J software: vessels area (VA), vessels density (VD), total number of junctions (TNJ), junctions density (JD), total vessel length (TVL), average vessel length (AVL), total number of endpoints (TNEP), lacunarity (L), vessel diameter index (VDI), tortuosity (T) and foveal avascular zone (FAZ). Average central macular thickness (CMT) and average central macular volume (CMV) were measured. Result Sixty-two eyes of 62 children of average age 50.4 ± 3.8 months were examined. VA, VD, and T increased from the inner towards the outer layers of the retina. The intermediate capillary plexus had the highest JD and TNEP and narrowest FAZ. Retinal sexual differentiation was supported with higher values of the retinal VA, VDI and TNEP, and chorioretinal VA, VDI and L in males. The choriocapillaris presented with the highest VD, AVL, and T and the lowest L and TNEP. Conclusion The study provides the first detailed normative database of the macular vascular network in the youngest uniform cohort of emmetropic four-year-old children. |
| first_indexed | 2024-12-17T12:40:06Z |
| format | Article |
| id | doaj.art-9f31d11bf8a34195bf4b5d8ce3c4e94e |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-12-17T12:40:06Z |
| publishDate | 2021-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-9f31d11bf8a34195bf4b5d8ce3c4e94e2022-12-21T21:48:04ZengBMCBMC Ophthalmology1471-24152021-10-0121111110.1186/s12886-021-02122-yMacular perfusion normative data acquired with optical coherence tomography angiography in healthy four-year-old Caucasian childrenDunja Bajtl0Mirjana Bjeloš1Mladen Bušić2Ana Križanović3Leon Marković4Biljana Kuzmanović Elabjer5University Eye Department, University Hospital Centre OsijekFaculty of Medicine, Josip Juraj Strossmayer University of OsijekFaculty of Medicine, Josip Juraj Strossmayer University of OsijekUniversity Eye Department, University Hospital “Sveti Duh”University Eye Department, University Hospital “Sveti Duh”Faculty of Medicine, Josip Juraj Strossmayer University of OsijekAbstract Background The purpose of this cross-sectional study involving healthy emmetropic four-year-old Caucasian children was to provide a macular perfusion normative database acquired with optical coherence tomography angiography (OCTA). One eye of each examinee underwent OCTA imaging. The following parameters were analyzed using AngioTool Image J software: vessels area (VA), vessels density (VD), total number of junctions (TNJ), junctions density (JD), total vessel length (TVL), average vessel length (AVL), total number of endpoints (TNEP), lacunarity (L), vessel diameter index (VDI), tortuosity (T) and foveal avascular zone (FAZ). Average central macular thickness (CMT) and average central macular volume (CMV) were measured. Result Sixty-two eyes of 62 children of average age 50.4 ± 3.8 months were examined. VA, VD, and T increased from the inner towards the outer layers of the retina. The intermediate capillary plexus had the highest JD and TNEP and narrowest FAZ. Retinal sexual differentiation was supported with higher values of the retinal VA, VDI and TNEP, and chorioretinal VA, VDI and L in males. The choriocapillaris presented with the highest VD, AVL, and T and the lowest L and TNEP. Conclusion The study provides the first detailed normative database of the macular vascular network in the youngest uniform cohort of emmetropic four-year-old children.https://doi.org/10.1186/s12886-021-02122-yChildrenRetinaPerfusionAngiographyRetinal vessels |
| spellingShingle | Dunja Bajtl Mirjana Bjeloš Mladen Bušić Ana Križanović Leon Marković Biljana Kuzmanović Elabjer Macular perfusion normative data acquired with optical coherence tomography angiography in healthy four-year-old Caucasian children BMC Ophthalmology Children Retina Perfusion Angiography Retinal vessels |
| title | Macular perfusion normative data acquired with optical coherence tomography angiography in healthy four-year-old Caucasian children |
| title_full | Macular perfusion normative data acquired with optical coherence tomography angiography in healthy four-year-old Caucasian children |
| title_fullStr | Macular perfusion normative data acquired with optical coherence tomography angiography in healthy four-year-old Caucasian children |
| title_full_unstemmed | Macular perfusion normative data acquired with optical coherence tomography angiography in healthy four-year-old Caucasian children |
| title_short | Macular perfusion normative data acquired with optical coherence tomography angiography in healthy four-year-old Caucasian children |
| title_sort | macular perfusion normative data acquired with optical coherence tomography angiography in healthy four year old caucasian children |
| topic | Children Retina Perfusion Angiography Retinal vessels |
| url | https://doi.org/10.1186/s12886-021-02122-y |
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