Methylenetetrahydrofolate Reductase C677T (rs1801133) Polymorphism Is Associated with Bladder Cancer in Asian Population: Epigenetic Meta-Analysis as Precision Medicine Approach
The etiology of bladder cancer remains unclear. This study investigates the impact of gene polymorphisms, particularly methylenetetrahydrofolate reductase gene (MTHFR), on bladder cancer susceptibility, focusing on the rs1801133 single-nucleotide polymorphism (SNP). A meta-analysis was conducted aft...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/17/4402 |
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| author | Athaya Febriantyo Purnomo Besut Daryanto Kurnia Penta Seputra Taufiq Nur Budaya Nurul Cholifah Lutfiana Fahrul Nurkolis Sanghyun Chung Jin Young Suh Moon Nyeo Park Byung-Kwan Seo Bonglee Kim |
| author_facet | Athaya Febriantyo Purnomo Besut Daryanto Kurnia Penta Seputra Taufiq Nur Budaya Nurul Cholifah Lutfiana Fahrul Nurkolis Sanghyun Chung Jin Young Suh Moon Nyeo Park Byung-Kwan Seo Bonglee Kim |
| author_sort | Athaya Febriantyo Purnomo |
| collection | DOAJ |
| description | The etiology of bladder cancer remains unclear. This study investigates the impact of gene polymorphisms, particularly methylenetetrahydrofolate reductase gene (MTHFR), on bladder cancer susceptibility, focusing on the rs1801133 single-nucleotide polymorphism (SNP). A meta-analysis was conducted after systematically reviewing the MTHFR gene literature, adhering to PRISMA guidelines and registering in PROSPERO (CRD42023423064). Seven studies were included, showing a significant association between the MTHFR C677T (rs1801133) polymorphism and bladder cancer susceptibility. Individuals with the T-allele or TT genotype had a higher likelihood of bladder cancer. In the Asian population, the overall analysis revealed an odds ratio (OR) of 1.15 (95% CI 1.03–1.30; <i>p</i>-value = 0.03) for T-allele versus C-allele and an OR of 1.34 (95% CI 1.04–1.72; <i>p</i>-value = 0.02) for TT genotype versus TC+CC genotype. The CC genotype, however, showed no significant association with bladder cancer. Notably, epigenetic findings displayed low sensitivity but high specificity, indicating reliable identified associations while potentially overlooking some epigenetic factors related to bladder cancer. In conclusion, the MTHFR T-allele and TT genotype were associated with increased bladder cancer risk in the Asian population. These insights into genetic factors influencing bladder cancer susceptibility could inform targeted prevention and treatment strategies. Further research is warranted to validate and expand these findings. |
| first_indexed | 2024-03-10T23:26:55Z |
| format | Article |
| id | doaj.art-9f3310cb8a9b4c28b467292a07d44899 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T23:26:55Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-9f3310cb8a9b4c28b467292a07d448992023-11-19T07:57:15ZengMDPI AGCancers2072-66942023-09-011517440210.3390/cancers15174402Methylenetetrahydrofolate Reductase C677T (rs1801133) Polymorphism Is Associated with Bladder Cancer in Asian Population: Epigenetic Meta-Analysis as Precision Medicine ApproachAthaya Febriantyo Purnomo0Besut Daryanto1Kurnia Penta Seputra2Taufiq Nur Budaya3Nurul Cholifah Lutfiana4Fahrul Nurkolis5Sanghyun Chung6Jin Young Suh7Moon Nyeo Park8Byung-Kwan Seo9Bonglee Kim10Department of Oncology, University of Oxford, Oxford OX3 7DQ, UKDepartment of Urology, Faculty of Medicine, Universitas Brawijaya, Malang 65142, IndonesiaDepartment of Urology, Faculty of Medicine, Universitas Brawijaya, Malang 65142, IndonesiaDepartment of Urology, Faculty of Medicine, Universitas Brawijaya, Malang 65142, IndonesiaDepartment of Biosciences and Biomedicine, Faculty of Medicine, Universitas Muhammadiyah Surabaya, Surabaya 36201, IndonesiaDepartment of Biological Sciences, State Islamic University of Sunan Kalijaga (UIN Sunan Kalijaga), Yogyakarta 55281, IndonesiaDepartment of Pathology, College of Korean Medicine, Kyung Hee University, Hoegidong Dongdaemun-gu, Seoul 02447, Republic of KoreaDepartment of Pathology, College of Korean Medicine, Kyung Hee University, Hoegidong Dongdaemun-gu, Seoul 02447, Republic of KoreaDepartment of Pathology, College of Korean Medicine, Kyung Hee University, Hoegidong Dongdaemun-gu, Seoul 02447, Republic of KoreaDepartment of Pathology, College of Korean Medicine, Kyung Hee University, Hoegidong Dongdaemun-gu, Seoul 02447, Republic of KoreaDepartment of Pathology, College of Korean Medicine, Kyung Hee University, Hoegidong Dongdaemun-gu, Seoul 02447, Republic of KoreaThe etiology of bladder cancer remains unclear. This study investigates the impact of gene polymorphisms, particularly methylenetetrahydrofolate reductase gene (MTHFR), on bladder cancer susceptibility, focusing on the rs1801133 single-nucleotide polymorphism (SNP). A meta-analysis was conducted after systematically reviewing the MTHFR gene literature, adhering to PRISMA guidelines and registering in PROSPERO (CRD42023423064). Seven studies were included, showing a significant association between the MTHFR C677T (rs1801133) polymorphism and bladder cancer susceptibility. Individuals with the T-allele or TT genotype had a higher likelihood of bladder cancer. In the Asian population, the overall analysis revealed an odds ratio (OR) of 1.15 (95% CI 1.03–1.30; <i>p</i>-value = 0.03) for T-allele versus C-allele and an OR of 1.34 (95% CI 1.04–1.72; <i>p</i>-value = 0.02) for TT genotype versus TC+CC genotype. The CC genotype, however, showed no significant association with bladder cancer. Notably, epigenetic findings displayed low sensitivity but high specificity, indicating reliable identified associations while potentially overlooking some epigenetic factors related to bladder cancer. In conclusion, the MTHFR T-allele and TT genotype were associated with increased bladder cancer risk in the Asian population. These insights into genetic factors influencing bladder cancer susceptibility could inform targeted prevention and treatment strategies. Further research is warranted to validate and expand these findings.https://www.mdpi.com/2072-6694/15/17/4402bladder cancerepigeneticmeta-analysismethylenetetrahydrofolate reductaseprecision medicine |
| spellingShingle | Athaya Febriantyo Purnomo Besut Daryanto Kurnia Penta Seputra Taufiq Nur Budaya Nurul Cholifah Lutfiana Fahrul Nurkolis Sanghyun Chung Jin Young Suh Moon Nyeo Park Byung-Kwan Seo Bonglee Kim Methylenetetrahydrofolate Reductase C677T (rs1801133) Polymorphism Is Associated with Bladder Cancer in Asian Population: Epigenetic Meta-Analysis as Precision Medicine Approach Cancers bladder cancer epigenetic meta-analysis methylenetetrahydrofolate reductase precision medicine |
| title | Methylenetetrahydrofolate Reductase C677T (rs1801133) Polymorphism Is Associated with Bladder Cancer in Asian Population: Epigenetic Meta-Analysis as Precision Medicine Approach |
| title_full | Methylenetetrahydrofolate Reductase C677T (rs1801133) Polymorphism Is Associated with Bladder Cancer in Asian Population: Epigenetic Meta-Analysis as Precision Medicine Approach |
| title_fullStr | Methylenetetrahydrofolate Reductase C677T (rs1801133) Polymorphism Is Associated with Bladder Cancer in Asian Population: Epigenetic Meta-Analysis as Precision Medicine Approach |
| title_full_unstemmed | Methylenetetrahydrofolate Reductase C677T (rs1801133) Polymorphism Is Associated with Bladder Cancer in Asian Population: Epigenetic Meta-Analysis as Precision Medicine Approach |
| title_short | Methylenetetrahydrofolate Reductase C677T (rs1801133) Polymorphism Is Associated with Bladder Cancer in Asian Population: Epigenetic Meta-Analysis as Precision Medicine Approach |
| title_sort | methylenetetrahydrofolate reductase c677t rs1801133 polymorphism is associated with bladder cancer in asian population epigenetic meta analysis as precision medicine approach |
| topic | bladder cancer epigenetic meta-analysis methylenetetrahydrofolate reductase precision medicine |
| url | https://www.mdpi.com/2072-6694/15/17/4402 |
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