3D Printed Pellets (Miniprintlets): A Novel, Multi-Drug, Controlled Release Platform Technology
Selective laser sintering (SLS) is a single-step three-dimensional printing (3DP) process that can be leveraged to engineer a wide array of drug delivery systems. The aim of this work was to utilise SLS 3DP, for the first time, to produce small oral dosage forms with modified release properties. As...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-03-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/11/4/148 |
| _version_ | 1798034389243789312 |
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| author | Atheer Awad Fabrizio Fina Sarah J. Trenfield Pavanesh Patel Alvaro Goyanes Simon Gaisford Abdul W. Basit |
| author_facet | Atheer Awad Fabrizio Fina Sarah J. Trenfield Pavanesh Patel Alvaro Goyanes Simon Gaisford Abdul W. Basit |
| author_sort | Atheer Awad |
| collection | DOAJ |
| description | Selective laser sintering (SLS) is a single-step three-dimensional printing (3DP) process that can be leveraged to engineer a wide array of drug delivery systems. The aim of this work was to utilise SLS 3DP, for the first time, to produce small oral dosage forms with modified release properties. As such, paracetamol-loaded 3D printed multiparticulates, termed miniprintlets, were fabricated in 1 mm and 2 mm diameters. Despite their large surface area compared with a conventional monolithic tablet, the ethyl cellulose-based miniprintlets exhibited prolonged drug release patterns. The possibility of producing miniprintlets combining two drugs, namely paracetamol and ibuprofen, was also investigated. By varying the polymer, the dual miniprintlets were programmed to achieve customised drug release patterns, whereby one drug was released immediately from a Kollicoat Instant Release matrix, whilst the effect of the second drug was sustained over an extended time span using ethyl cellulose. Herein, this work has highlighted the versatility of SLS 3DP to fabricate small and intricate formulations containing multiple active pharmaceutical ingredients with distinct release properties. |
| first_indexed | 2024-04-11T20:43:42Z |
| format | Article |
| id | doaj.art-9f359ba02b434855a0e452dfee253f53 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-11T20:43:42Z |
| publishDate | 2019-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-9f359ba02b434855a0e452dfee253f532022-12-22T04:04:07ZengMDPI AGPharmaceutics1999-49232019-03-0111414810.3390/pharmaceutics11040148pharmaceutics110401483D Printed Pellets (Miniprintlets): A Novel, Multi-Drug, Controlled Release Platform TechnologyAtheer Awad0Fabrizio Fina1Sarah J. Trenfield2Pavanesh Patel3Alvaro Goyanes4Simon Gaisford5Abdul W. Basit6Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UKDepartment of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UKDepartment of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UKDepartment of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UKFabRx Ltd., 3 Romney Road, Ashford, Kent TN24 0RW, UKDepartment of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UKDepartment of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UKSelective laser sintering (SLS) is a single-step three-dimensional printing (3DP) process that can be leveraged to engineer a wide array of drug delivery systems. The aim of this work was to utilise SLS 3DP, for the first time, to produce small oral dosage forms with modified release properties. As such, paracetamol-loaded 3D printed multiparticulates, termed miniprintlets, were fabricated in 1 mm and 2 mm diameters. Despite their large surface area compared with a conventional monolithic tablet, the ethyl cellulose-based miniprintlets exhibited prolonged drug release patterns. The possibility of producing miniprintlets combining two drugs, namely paracetamol and ibuprofen, was also investigated. By varying the polymer, the dual miniprintlets were programmed to achieve customised drug release patterns, whereby one drug was released immediately from a Kollicoat Instant Release matrix, whilst the effect of the second drug was sustained over an extended time span using ethyl cellulose. Herein, this work has highlighted the versatility of SLS 3DP to fabricate small and intricate formulations containing multiple active pharmaceutical ingredients with distinct release properties.https://www.mdpi.com/1999-4923/11/4/148three dimensional printingadditive manufacturing3D printed drug productsprintletspersonalised medicinespersonalized pharmaceuticalsmultiple unitsspheroidsbeadsacetaminophen |
| spellingShingle | Atheer Awad Fabrizio Fina Sarah J. Trenfield Pavanesh Patel Alvaro Goyanes Simon Gaisford Abdul W. Basit 3D Printed Pellets (Miniprintlets): A Novel, Multi-Drug, Controlled Release Platform Technology Pharmaceutics three dimensional printing additive manufacturing 3D printed drug products printlets personalised medicines personalized pharmaceuticals multiple units spheroids beads acetaminophen |
| title | 3D Printed Pellets (Miniprintlets): A Novel, Multi-Drug, Controlled Release Platform Technology |
| title_full | 3D Printed Pellets (Miniprintlets): A Novel, Multi-Drug, Controlled Release Platform Technology |
| title_fullStr | 3D Printed Pellets (Miniprintlets): A Novel, Multi-Drug, Controlled Release Platform Technology |
| title_full_unstemmed | 3D Printed Pellets (Miniprintlets): A Novel, Multi-Drug, Controlled Release Platform Technology |
| title_short | 3D Printed Pellets (Miniprintlets): A Novel, Multi-Drug, Controlled Release Platform Technology |
| title_sort | 3d printed pellets miniprintlets a novel multi drug controlled release platform technology |
| topic | three dimensional printing additive manufacturing 3D printed drug products printlets personalised medicines personalized pharmaceuticals multiple units spheroids beads acetaminophen |
| url | https://www.mdpi.com/1999-4923/11/4/148 |
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