IgA Vasculitis Complicated by Both CMV Reactivation and Tuberculosis
Immunoglobulin A (IgA) vasculitis is the most common systemic vasculitis in the pediatric population. We present the case of a patient with IgA vasculitis with nephritis who developed cytomegalovirus (CMV) infection followed by Mycobacterium tuberculosis infection. In the literature, there are a few...
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MDPI AG
2021-07-01
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| Series: | Pediatric Reports |
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| Online Access: | https://www.mdpi.com/2036-7503/13/3/48 |
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| author | Małgorzata Mizerska-Wasiak Maria Winiarska Karolina Nogal Karolina Cichoń-Kawa Małgorzata Pańczyk-Tomaszewska Jadwiga Małdyk |
| author_facet | Małgorzata Mizerska-Wasiak Maria Winiarska Karolina Nogal Karolina Cichoń-Kawa Małgorzata Pańczyk-Tomaszewska Jadwiga Małdyk |
| author_sort | Małgorzata Mizerska-Wasiak |
| collection | DOAJ |
| description | Immunoglobulin A (IgA) vasculitis is the most common systemic vasculitis in the pediatric population. We present the case of a patient with IgA vasculitis with nephritis who developed cytomegalovirus (CMV) infection followed by Mycobacterium tuberculosis infection. In the literature, there are a few cases of IgA nephropathy accompanied by reactivation of CMV or tuberculosis. To the best of our knowledge, this is the first reported case of IgA vasculitis complicated by both CMV reactivation and tuberculosis. It is important to detect infections in patients with IgA vasculitis because they can induce and exacerbate the symptoms of the disease. Effective antimicrobial treatment facilitates the management of proteinuria and slows down the decline of renal function. Immunosuppressive therapy is a risk factor for reactivation of latent infections and makes patients more susceptible to its generalized and complicated course. This can be prevented by actively screening for hidden sites of infection. |
| first_indexed | 2024-03-10T07:19:28Z |
| format | Article |
| id | doaj.art-9f377558fe4c474983b2f457ff0603f9 |
| institution | Directory Open Access Journal |
| issn | 2036-7503 |
| language | English |
| last_indexed | 2024-03-10T07:19:28Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pediatric Reports |
| spelling | doaj.art-9f377558fe4c474983b2f457ff0603f92023-11-22T14:43:49ZengMDPI AGPediatric Reports2036-75032021-07-0113341642010.3390/pediatric13030048IgA Vasculitis Complicated by Both CMV Reactivation and TuberculosisMałgorzata Mizerska-Wasiak0Maria Winiarska1Karolina Nogal2Karolina Cichoń-Kawa3Małgorzata Pańczyk-Tomaszewska4Jadwiga Małdyk5Department of Pediatrics and Nephrology, Medical University of Warsaw, 02-091 Warsaw, PolandStudent’s Scientific Group at the Department of Pediatrics and Nephrology, Medical University of Warsaw, 02-091 Warsaw, PolandStudent’s Scientific Group at the Department of Pediatrics and Nephrology, Medical University of Warsaw, 02-091 Warsaw, PolandDepartment of Pediatrics and Nephrology, Medical University of Warsaw, 02-091 Warsaw, PolandDepartment of Pediatrics and Nephrology, Medical University of Warsaw, 02-091 Warsaw, PolandDepartment of Pathology, Medical University of Warsaw, 02-091 Warsaw, PolandImmunoglobulin A (IgA) vasculitis is the most common systemic vasculitis in the pediatric population. We present the case of a patient with IgA vasculitis with nephritis who developed cytomegalovirus (CMV) infection followed by Mycobacterium tuberculosis infection. In the literature, there are a few cases of IgA nephropathy accompanied by reactivation of CMV or tuberculosis. To the best of our knowledge, this is the first reported case of IgA vasculitis complicated by both CMV reactivation and tuberculosis. It is important to detect infections in patients with IgA vasculitis because they can induce and exacerbate the symptoms of the disease. Effective antimicrobial treatment facilitates the management of proteinuria and slows down the decline of renal function. Immunosuppressive therapy is a risk factor for reactivation of latent infections and makes patients more susceptible to its generalized and complicated course. This can be prevented by actively screening for hidden sites of infection.https://www.mdpi.com/2036-7503/13/3/48tuberculosisCMVIgA nephropathyIgA vasculitisproteinuriaimmunosuppressive therapy |
| spellingShingle | Małgorzata Mizerska-Wasiak Maria Winiarska Karolina Nogal Karolina Cichoń-Kawa Małgorzata Pańczyk-Tomaszewska Jadwiga Małdyk IgA Vasculitis Complicated by Both CMV Reactivation and Tuberculosis Pediatric Reports tuberculosis CMV IgA nephropathy IgA vasculitis proteinuria immunosuppressive therapy |
| title | IgA Vasculitis Complicated by Both CMV Reactivation and Tuberculosis |
| title_full | IgA Vasculitis Complicated by Both CMV Reactivation and Tuberculosis |
| title_fullStr | IgA Vasculitis Complicated by Both CMV Reactivation and Tuberculosis |
| title_full_unstemmed | IgA Vasculitis Complicated by Both CMV Reactivation and Tuberculosis |
| title_short | IgA Vasculitis Complicated by Both CMV Reactivation and Tuberculosis |
| title_sort | iga vasculitis complicated by both cmv reactivation and tuberculosis |
| topic | tuberculosis CMV IgA nephropathy IgA vasculitis proteinuria immunosuppressive therapy |
| url | https://www.mdpi.com/2036-7503/13/3/48 |
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