Development of a Manufacturing Process toward the Convergent Synthesis of the COVID-19 Antiviral Ensitrelvir
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
American Chemical Society
2023-04-01
|
| Series: | ACS Central Science |
| Online Access: | https://doi.org/10.1021/acscentsci.2c01203 |
| _version_ | 1797838996403912704 |
|---|---|
| author | Takahiro Kawajiri Akihito Kijima Atsuhiro Iimuro Eisaku Ohashi Katsuya Yamakawa Kazushi Agura Kengo Masuda Kensuke Kouki Koji Kasamatsu Shuichi Yanagisawa Sho Nakashima Setsuya Shibahara Takashi Toyota Takafumi Higuchi Takahiro Suto Tadashi Oohara Toshikatsu Maki Naoto Sahara Nobuaki Fukui Hisayuki Wakamori Hidaka Ikemoto Hiroaki Murakami Hiroyasu Ando Masahiro Hosoya Mizuki Sato Yusuke Suzuki Yuta Nakagawa Yuto Unoh Yoichi Hirano Yoshitomo Nagasawa Satoshi Goda Takafumi Ohara Takayuki Tsuritani |
| author_facet | Takahiro Kawajiri Akihito Kijima Atsuhiro Iimuro Eisaku Ohashi Katsuya Yamakawa Kazushi Agura Kengo Masuda Kensuke Kouki Koji Kasamatsu Shuichi Yanagisawa Sho Nakashima Setsuya Shibahara Takashi Toyota Takafumi Higuchi Takahiro Suto Tadashi Oohara Toshikatsu Maki Naoto Sahara Nobuaki Fukui Hisayuki Wakamori Hidaka Ikemoto Hiroaki Murakami Hiroyasu Ando Masahiro Hosoya Mizuki Sato Yusuke Suzuki Yuta Nakagawa Yuto Unoh Yoichi Hirano Yoshitomo Nagasawa Satoshi Goda Takafumi Ohara Takayuki Tsuritani |
| author_sort | Takahiro Kawajiri |
| collection | DOAJ |
| first_indexed | 2024-04-09T15:51:01Z |
| format | Article |
| id | doaj.art-9f38b46b1b194cdaac85377b26776798 |
| institution | Directory Open Access Journal |
| issn | 2374-7951 |
| language | English |
| last_indexed | 2024-04-09T15:51:01Z |
| publishDate | 2023-04-01 |
| publisher | American Chemical Society |
| record_format | Article |
| series | ACS Central Science |
| spelling | doaj.art-9f38b46b1b194cdaac85377b267767982023-04-26T07:39:55ZengAmerican Chemical SocietyACS Central Science2374-79512023-04-019483684310.1021/acscentsci.2c01203Development of a Manufacturing Process toward the Convergent Synthesis of the COVID-19 Antiviral EnsitrelvirTakahiro Kawajiri0Akihito Kijima1Atsuhiro Iimuro2Eisaku Ohashi3Katsuya Yamakawa4Kazushi Agura5Kengo Masuda6Kensuke Kouki7Koji Kasamatsu8Shuichi Yanagisawa9Sho Nakashima10Setsuya Shibahara11Takashi Toyota12Takafumi Higuchi13Takahiro Suto14Tadashi Oohara15Toshikatsu Maki16Naoto Sahara17Nobuaki Fukui18Hisayuki Wakamori19Hidaka Ikemoto20Hiroaki Murakami21Hiroyasu Ando22Masahiro Hosoya23Mizuki Sato24Yusuke Suzuki25Yuta Nakagawa26Yuto Unoh27Yoichi Hirano28Yoshitomo Nagasawa29Satoshi Goda30Takafumi Ohara31Takayuki Tsuritani32API R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, JapanAPI R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, JapanLaboratory for Medicinal Chemistry Research, Research Division, Shionogi & Co., Ltd., Toyonaka, Osaka, JapanAPI R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, JapanAPI R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, JapanAPI R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, JapanLaboratory for Medicinal Chemistry Research, Research Division, Shionogi & Co., Ltd., Toyonaka, Osaka, JapanLaboratory for Medicinal Chemistry Research, Research Division, Shionogi & Co., Ltd., Toyonaka, Osaka, JapanLaboratory for Medicinal Chemistry Research, Research Division, Shionogi & Co., Ltd., Toyonaka, Osaka, JapanAPI R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, JapanAPI R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, JapanAPI R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, JapanAPI R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, JapanAPI R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, JapanLaboratory for Medicinal Chemistry Research, Research Division, Shionogi & Co., Ltd., Toyonaka, Osaka, JapanAPI R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, JapanAPI R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, JapanAPI R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, JapanAPI R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, JapanAPI R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, JapanAPI R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, JapanAPI R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, JapanAPI R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, JapanAPI R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, JapanAPI R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, JapanAPI R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, JapanAPI R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, JapanLaboratory for Medicinal Chemistry Research, Research Division, Shionogi & Co., Ltd., Toyonaka, Osaka, JapanAPI R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, JapanAPI R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, JapanAPI R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, JapanAPI R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, JapanAPI R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, Japanhttps://doi.org/10.1021/acscentsci.2c01203 |
| spellingShingle | Takahiro Kawajiri Akihito Kijima Atsuhiro Iimuro Eisaku Ohashi Katsuya Yamakawa Kazushi Agura Kengo Masuda Kensuke Kouki Koji Kasamatsu Shuichi Yanagisawa Sho Nakashima Setsuya Shibahara Takashi Toyota Takafumi Higuchi Takahiro Suto Tadashi Oohara Toshikatsu Maki Naoto Sahara Nobuaki Fukui Hisayuki Wakamori Hidaka Ikemoto Hiroaki Murakami Hiroyasu Ando Masahiro Hosoya Mizuki Sato Yusuke Suzuki Yuta Nakagawa Yuto Unoh Yoichi Hirano Yoshitomo Nagasawa Satoshi Goda Takafumi Ohara Takayuki Tsuritani Development of a Manufacturing Process toward the Convergent Synthesis of the COVID-19 Antiviral Ensitrelvir ACS Central Science |
| title | Development of a Manufacturing Process toward the Convergent Synthesis of the COVID-19 Antiviral Ensitrelvir |
| title_full | Development of a Manufacturing Process toward the Convergent Synthesis of the COVID-19 Antiviral Ensitrelvir |
| title_fullStr | Development of a Manufacturing Process toward the Convergent Synthesis of the COVID-19 Antiviral Ensitrelvir |
| title_full_unstemmed | Development of a Manufacturing Process toward the Convergent Synthesis of the COVID-19 Antiviral Ensitrelvir |
| title_short | Development of a Manufacturing Process toward the Convergent Synthesis of the COVID-19 Antiviral Ensitrelvir |
| title_sort | development of a manufacturing process toward the convergent synthesis of the covid 19 antiviral ensitrelvir |
| url | https://doi.org/10.1021/acscentsci.2c01203 |
| work_keys_str_mv | AT takahirokawajiri developmentofamanufacturingprocesstowardtheconvergentsynthesisofthecovid19antiviralensitrelvir AT akihitokijima developmentofamanufacturingprocesstowardtheconvergentsynthesisofthecovid19antiviralensitrelvir AT atsuhiroiimuro developmentofamanufacturingprocesstowardtheconvergentsynthesisofthecovid19antiviralensitrelvir AT eisakuohashi developmentofamanufacturingprocesstowardtheconvergentsynthesisofthecovid19antiviralensitrelvir AT katsuyayamakawa developmentofamanufacturingprocesstowardtheconvergentsynthesisofthecovid19antiviralensitrelvir AT kazushiagura developmentofamanufacturingprocesstowardtheconvergentsynthesisofthecovid19antiviralensitrelvir AT kengomasuda developmentofamanufacturingprocesstowardtheconvergentsynthesisofthecovid19antiviralensitrelvir AT kensukekouki developmentofamanufacturingprocesstowardtheconvergentsynthesisofthecovid19antiviralensitrelvir AT kojikasamatsu developmentofamanufacturingprocesstowardtheconvergentsynthesisofthecovid19antiviralensitrelvir AT shuichiyanagisawa developmentofamanufacturingprocesstowardtheconvergentsynthesisofthecovid19antiviralensitrelvir AT shonakashima developmentofamanufacturingprocesstowardtheconvergentsynthesisofthecovid19antiviralensitrelvir AT setsuyashibahara developmentofamanufacturingprocesstowardtheconvergentsynthesisofthecovid19antiviralensitrelvir AT takashitoyota developmentofamanufacturingprocesstowardtheconvergentsynthesisofthecovid19antiviralensitrelvir AT takafumihiguchi developmentofamanufacturingprocesstowardtheconvergentsynthesisofthecovid19antiviralensitrelvir AT takahirosuto developmentofamanufacturingprocesstowardtheconvergentsynthesisofthecovid19antiviralensitrelvir AT tadashioohara developmentofamanufacturingprocesstowardtheconvergentsynthesisofthecovid19antiviralensitrelvir AT toshikatsumaki developmentofamanufacturingprocesstowardtheconvergentsynthesisofthecovid19antiviralensitrelvir AT naotosahara developmentofamanufacturingprocesstowardtheconvergentsynthesisofthecovid19antiviralensitrelvir AT nobuakifukui developmentofamanufacturingprocesstowardtheconvergentsynthesisofthecovid19antiviralensitrelvir AT hisayukiwakamori developmentofamanufacturingprocesstowardtheconvergentsynthesisofthecovid19antiviralensitrelvir AT hidakaikemoto developmentofamanufacturingprocesstowardtheconvergentsynthesisofthecovid19antiviralensitrelvir AT hiroakimurakami developmentofamanufacturingprocesstowardtheconvergentsynthesisofthecovid19antiviralensitrelvir AT hiroyasuando developmentofamanufacturingprocesstowardtheconvergentsynthesisofthecovid19antiviralensitrelvir AT masahirohosoya developmentofamanufacturingprocesstowardtheconvergentsynthesisofthecovid19antiviralensitrelvir AT mizukisato developmentofamanufacturingprocesstowardtheconvergentsynthesisofthecovid19antiviralensitrelvir AT yusukesuzuki developmentofamanufacturingprocesstowardtheconvergentsynthesisofthecovid19antiviralensitrelvir AT yutanakagawa developmentofamanufacturingprocesstowardtheconvergentsynthesisofthecovid19antiviralensitrelvir AT yutounoh developmentofamanufacturingprocesstowardtheconvergentsynthesisofthecovid19antiviralensitrelvir AT yoichihirano developmentofamanufacturingprocesstowardtheconvergentsynthesisofthecovid19antiviralensitrelvir AT yoshitomonagasawa developmentofamanufacturingprocesstowardtheconvergentsynthesisofthecovid19antiviralensitrelvir AT satoshigoda developmentofamanufacturingprocesstowardtheconvergentsynthesisofthecovid19antiviralensitrelvir AT takafumiohara developmentofamanufacturingprocesstowardtheconvergentsynthesisofthecovid19antiviralensitrelvir AT takayukitsuritani developmentofamanufacturingprocesstowardtheconvergentsynthesisofthecovid19antiviralensitrelvir |