P183 INCREASED ARTERIAL STIFFNESS IS ASSOCIATED WITH POORER LEFT VENTRICULAR STRUCTURE AND FUNCTION IN ADOLESCENCE
Introduction: Increased arterial stiffness (AS) in adults causes increased left ventricular (LV) afterload, putting additional strain on the heart. Long-term, this can lead to an adverse cardiovascular phenotype and AS has been found to be a determinant of CVD, independent of traditional cardiovascu...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2017-12-01
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| Series: | Artery Research |
| Online Access: | https://www.atlantis-press.com/article/125930358/view |
| _version_ | 1811301759731105792 |
|---|---|
| author | Hannah Taylor Alun Hughes Marietta Charakida Nishi Chaturvedi George Davey- Smith John Deanfield Abigail Fraser Laura Howe Debbie Lawlor Chloe Park |
| author_facet | Hannah Taylor Alun Hughes Marietta Charakida Nishi Chaturvedi George Davey- Smith John Deanfield Abigail Fraser Laura Howe Debbie Lawlor Chloe Park |
| author_sort | Hannah Taylor |
| collection | DOAJ |
| description | Introduction: Increased arterial stiffness (AS) in adults causes increased left ventricular (LV) afterload, putting additional strain on the heart. Long-term, this can lead to an adverse cardiovascular phenotype and AS has been found to be a determinant of CVD, independent of traditional cardiovascular risk factors. However, limited evidence exists for this association in children and adolescents.
Methods: 1625 young adults (age 17y; 46% male) from the Avon Longitudinal Study of Parents and Children (ALSPAC), a UK based birth cohort, underwent echocardiography and carotid-to-femoral pulse wave velocity (PWV) measures. Linear regression was used to investigate associations between PWV and LV structure and function, including LV mass, relative wall thickness (RWT), left atrial diameter (LAD), mitral inflow (E:A), midwall fractional shortening (MFS) and tissue Doppler peak systolic velocity (s′).
Results: Elevated PWV was associated with increased LV mass and RWT and inversely associated with E:A and MFS (Table 1). Adjustment for age and sex attenuated the association with LV mass. Further adjustment for body mass index (BMI), systolic blood pressure (SBP), alcohol, smoking and socioeconomic status (SES) attenuated the association with RWT, whilst the associations with E:A and MFS remained.
Unadjusted
Age and sex adjusted
Age, sex, BMI, SBP, alcohol, smoking, SES adjusted
Coefficient±SE
P value
Coefficient±SE
P value
Coefficient±SE
P value
LV mass2.7 (g/m2.7)
0.55±0.21
0.009
−0.066±0.225
0.768
−0.123±0.225
0.584
RWT
0.007±0.002
<0.001
0.008±0.002
<0.001
0.005±0.00
0.069
LAD (cm)
−0.004±0.015
0.784
−0.017±0.015
0.268
−0.010±0.016
0.516
E:A
−0.054±0.014
<0.001
−0.073±0.015
<0.001
−0.067±0.019
<0.001
MFS (%)
−0.40±0.079
<0.001
−0.246±0.085
0.004
−0.232±0.1
0.022
s′ (cm/s)
0.078±0.05
0.138
0.004±0.057
0.937
−0.038±0.067
0.567
Conclusion: Increased AS is already associated with poorer measures of LV structure and function in adolescence. Adjustment for potential confounders did not substantially attenuate these associations with LV function. |
| first_indexed | 2024-04-13T07:15:53Z |
| format | Article |
| id | doaj.art-9f3d29d322184a22b3c6c0ee2c6e278f |
| institution | Directory Open Access Journal |
| issn | 1876-4401 |
| language | English |
| last_indexed | 2024-04-13T07:15:53Z |
| publishDate | 2017-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Artery Research |
| spelling | doaj.art-9f3d29d322184a22b3c6c0ee2c6e278f2022-12-22T02:56:46ZengBMCArtery Research1876-44012017-12-012010.1016/j.artres.2017.10.184P183 INCREASED ARTERIAL STIFFNESS IS ASSOCIATED WITH POORER LEFT VENTRICULAR STRUCTURE AND FUNCTION IN ADOLESCENCEHannah TaylorAlun HughesMarietta CharakidaNishi ChaturvediGeorge Davey- SmithJohn DeanfieldAbigail FraserLaura HoweDebbie LawlorChloe ParkIntroduction: Increased arterial stiffness (AS) in adults causes increased left ventricular (LV) afterload, putting additional strain on the heart. Long-term, this can lead to an adverse cardiovascular phenotype and AS has been found to be a determinant of CVD, independent of traditional cardiovascular risk factors. However, limited evidence exists for this association in children and adolescents. Methods: 1625 young adults (age 17y; 46% male) from the Avon Longitudinal Study of Parents and Children (ALSPAC), a UK based birth cohort, underwent echocardiography and carotid-to-femoral pulse wave velocity (PWV) measures. Linear regression was used to investigate associations between PWV and LV structure and function, including LV mass, relative wall thickness (RWT), left atrial diameter (LAD), mitral inflow (E:A), midwall fractional shortening (MFS) and tissue Doppler peak systolic velocity (s′). Results: Elevated PWV was associated with increased LV mass and RWT and inversely associated with E:A and MFS (Table 1). Adjustment for age and sex attenuated the association with LV mass. Further adjustment for body mass index (BMI), systolic blood pressure (SBP), alcohol, smoking and socioeconomic status (SES) attenuated the association with RWT, whilst the associations with E:A and MFS remained. Unadjusted Age and sex adjusted Age, sex, BMI, SBP, alcohol, smoking, SES adjusted Coefficient±SE P value Coefficient±SE P value Coefficient±SE P value LV mass2.7 (g/m2.7) 0.55±0.21 0.009 −0.066±0.225 0.768 −0.123±0.225 0.584 RWT 0.007±0.002 <0.001 0.008±0.002 <0.001 0.005±0.00 0.069 LAD (cm) −0.004±0.015 0.784 −0.017±0.015 0.268 −0.010±0.016 0.516 E:A −0.054±0.014 <0.001 −0.073±0.015 <0.001 −0.067±0.019 <0.001 MFS (%) −0.40±0.079 <0.001 −0.246±0.085 0.004 −0.232±0.1 0.022 s′ (cm/s) 0.078±0.05 0.138 0.004±0.057 0.937 −0.038±0.067 0.567 Conclusion: Increased AS is already associated with poorer measures of LV structure and function in adolescence. Adjustment for potential confounders did not substantially attenuate these associations with LV function.https://www.atlantis-press.com/article/125930358/view |
| spellingShingle | Hannah Taylor Alun Hughes Marietta Charakida Nishi Chaturvedi George Davey- Smith John Deanfield Abigail Fraser Laura Howe Debbie Lawlor Chloe Park P183 INCREASED ARTERIAL STIFFNESS IS ASSOCIATED WITH POORER LEFT VENTRICULAR STRUCTURE AND FUNCTION IN ADOLESCENCE Artery Research |
| title | P183 INCREASED ARTERIAL STIFFNESS IS ASSOCIATED WITH POORER LEFT VENTRICULAR STRUCTURE AND FUNCTION IN ADOLESCENCE |
| title_full | P183 INCREASED ARTERIAL STIFFNESS IS ASSOCIATED WITH POORER LEFT VENTRICULAR STRUCTURE AND FUNCTION IN ADOLESCENCE |
| title_fullStr | P183 INCREASED ARTERIAL STIFFNESS IS ASSOCIATED WITH POORER LEFT VENTRICULAR STRUCTURE AND FUNCTION IN ADOLESCENCE |
| title_full_unstemmed | P183 INCREASED ARTERIAL STIFFNESS IS ASSOCIATED WITH POORER LEFT VENTRICULAR STRUCTURE AND FUNCTION IN ADOLESCENCE |
| title_short | P183 INCREASED ARTERIAL STIFFNESS IS ASSOCIATED WITH POORER LEFT VENTRICULAR STRUCTURE AND FUNCTION IN ADOLESCENCE |
| title_sort | p183 increased arterial stiffness is associated with poorer left ventricular structure and function in adolescence |
| url | https://www.atlantis-press.com/article/125930358/view |
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