Polyglycerol Adipate-Grafted Polycaprolactone Nanoparticles as Carriers for the Antimicrobial Compound Usnic Acid
Nanoparticle (NP) drug delivery systems are known to potentially enhance the efficacy of therapeutic agents. As for antimicrobial drugs, therapeutic solutions against drug-resistant microbes are urgently needed due to the worldwide antimicrobial resistance issue. Usnic acid is a widely investigated...
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MDPI AG
2022-11-01
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author | Vincenzo Taresco Isotta Tulini Iolanda Francolini Antonella Piozzi |
author_facet | Vincenzo Taresco Isotta Tulini Iolanda Francolini Antonella Piozzi |
author_sort | Vincenzo Taresco |
collection | DOAJ |
description | Nanoparticle (NP) drug delivery systems are known to potentially enhance the efficacy of therapeutic agents. As for antimicrobial drugs, therapeutic solutions against drug-resistant microbes are urgently needed due to the worldwide antimicrobial resistance issue. Usnic acid is a widely investigated antimicrobial agent suffering from poor water solubility. In this study, polymer nanoparticles based on polyglycerol adipate (PGA) grafted with polycaprolactone (PCL) were developed as carriers for usnic acid. We demonstrated the potential of the developed systems in ensuring prolonged bactericidal activity against a model bacterial species, <i>Staphylococcus epidermidis</i>. The macromolecular architecture changes produced by PCL grafted from PGA significantly influenced the drug release profile and mechanism. Specifically, by varying the length of PCL arms linked to the PGA backbone, it was possible to tune the drug release from a burst anomalous drug release (high PCL chain length) to a slow diffusion-controlled release (low PCL chain length). The developed nanosystems showed a prolonged antimicrobial activity (up to at least 7 days) which could be used in preventing/treating infections occurring at different body sites, including medical device-related infection and mucosal/skin surface, where Gram-positive bacteria are commonly involved. |
first_indexed | 2024-03-09T18:15:53Z |
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id | doaj.art-9f3f67d19251444a8b7eed4a917ffc06 |
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issn | 1661-6596 1422-0067 |
language | English |
last_indexed | 2024-03-09T18:15:53Z |
publishDate | 2022-11-01 |
publisher | MDPI AG |
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series | International Journal of Molecular Sciences |
spelling | doaj.art-9f3f67d19251444a8b7eed4a917ffc062023-11-24T08:42:35ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-11-0123221433910.3390/ijms232214339Polyglycerol Adipate-Grafted Polycaprolactone Nanoparticles as Carriers for the Antimicrobial Compound Usnic AcidVincenzo Taresco0Isotta Tulini1Iolanda Francolini2Antonella Piozzi3Department of Chemistry, The University of Nottingham, Nottingham NG7 2RD, UKDepartment of Chemistry, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Chemistry, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Chemistry, Sapienza University of Rome, 00185 Rome, ItalyNanoparticle (NP) drug delivery systems are known to potentially enhance the efficacy of therapeutic agents. As for antimicrobial drugs, therapeutic solutions against drug-resistant microbes are urgently needed due to the worldwide antimicrobial resistance issue. Usnic acid is a widely investigated antimicrobial agent suffering from poor water solubility. In this study, polymer nanoparticles based on polyglycerol adipate (PGA) grafted with polycaprolactone (PCL) were developed as carriers for usnic acid. We demonstrated the potential of the developed systems in ensuring prolonged bactericidal activity against a model bacterial species, <i>Staphylococcus epidermidis</i>. The macromolecular architecture changes produced by PCL grafted from PGA significantly influenced the drug release profile and mechanism. Specifically, by varying the length of PCL arms linked to the PGA backbone, it was possible to tune the drug release from a burst anomalous drug release (high PCL chain length) to a slow diffusion-controlled release (low PCL chain length). The developed nanosystems showed a prolonged antimicrobial activity (up to at least 7 days) which could be used in preventing/treating infections occurring at different body sites, including medical device-related infection and mucosal/skin surface, where Gram-positive bacteria are commonly involved.https://www.mdpi.com/1422-0067/23/22/14339nanoparticlespolyglycerol adipatepolycaprolactoneusnic acidmicrobial infectionsdrug release |
spellingShingle | Vincenzo Taresco Isotta Tulini Iolanda Francolini Antonella Piozzi Polyglycerol Adipate-Grafted Polycaprolactone Nanoparticles as Carriers for the Antimicrobial Compound Usnic Acid International Journal of Molecular Sciences nanoparticles polyglycerol adipate polycaprolactone usnic acid microbial infections drug release |
title | Polyglycerol Adipate-Grafted Polycaprolactone Nanoparticles as Carriers for the Antimicrobial Compound Usnic Acid |
title_full | Polyglycerol Adipate-Grafted Polycaprolactone Nanoparticles as Carriers for the Antimicrobial Compound Usnic Acid |
title_fullStr | Polyglycerol Adipate-Grafted Polycaprolactone Nanoparticles as Carriers for the Antimicrobial Compound Usnic Acid |
title_full_unstemmed | Polyglycerol Adipate-Grafted Polycaprolactone Nanoparticles as Carriers for the Antimicrobial Compound Usnic Acid |
title_short | Polyglycerol Adipate-Grafted Polycaprolactone Nanoparticles as Carriers for the Antimicrobial Compound Usnic Acid |
title_sort | polyglycerol adipate grafted polycaprolactone nanoparticles as carriers for the antimicrobial compound usnic acid |
topic | nanoparticles polyglycerol adipate polycaprolactone usnic acid microbial infections drug release |
url | https://www.mdpi.com/1422-0067/23/22/14339 |
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