Clinicopathological features of primary thyroid Burkitt’s lymphoma: a systematic review and meta-analysis
Abstract Background Primary thyroid Burkitt’s lymphoma (BL) is an extremely rare and highly aggressive form of non-Hodgkin’s lymphoma; only isolated case reports are available for patients with this disease. Methods We analyzed the clinicopathological features of thyroid BL by conducting a meta-anal...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-02-01
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| Series: | Diagnostic Pathology |
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| Online Access: | https://doi.org/10.1186/s13000-020-00933-z |
| _version_ | 1818575890041274368 |
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| author | Toshitetsu Hayashi Mitsuyoshi Hirokawa Seiji Kuma Miyoko Higuchi Ayana Suzuki Risa Kanematsu Takumi Kudo Naomi Katsuki Reiji Haba Akira Miyauchi |
| author_facet | Toshitetsu Hayashi Mitsuyoshi Hirokawa Seiji Kuma Miyoko Higuchi Ayana Suzuki Risa Kanematsu Takumi Kudo Naomi Katsuki Reiji Haba Akira Miyauchi |
| author_sort | Toshitetsu Hayashi |
| collection | DOAJ |
| description | Abstract Background Primary thyroid Burkitt’s lymphoma (BL) is an extremely rare and highly aggressive form of non-Hodgkin’s lymphoma; only isolated case reports are available for patients with this disease. Methods We analyzed the clinicopathological features of thyroid BL by conducting a meta-analysis of 21 known patients (including ours) and compared them to those of extrathyroidal BL. Results There were 13 men and 8 women with a median age of 39.3 years (range, 6–75 years). The median follow-up was 46.5 months (range, 0.5–361 months). Six patients (28.6%) had stage I disease, 2 (9.5%) had stage II, 2 (9.5%) had stage III, and 11 (52.4%) had stage IV. Five of 7 tested patients with thyroid BL (71.4%) had histological evidence of underlying Hashimoto’s thyroiditis. Ki-67 labeling indices exceeding 90% in all 19 patients tested (100%). Fluorescence in situ hybridization performed on 12 patient samples revealed that all (100%) had MYC rearrangement. Among the 16 patients for whom follow-up data were available, 4 died of disease-related causes. Kaplan-Meier analysis revealed that the 12- and 60-month overall survival rates for patients with thyroid BL were 87.5 and 70.7%, respectively. Conclusions Ours was the largest study of thyroid BL and its detailed clinicopathological features to date. Thyroid BL is not associated with underlying Epstein-Barr virus infection but is closely linked to Hashimoto’s thyroiditis; patients generally have good overall survival and respond well to intensive chemotherapy. The correct pathological diagnosis is essential for treatment selection and outcome improvement. |
| first_indexed | 2024-12-15T00:47:16Z |
| format | Article |
| id | doaj.art-9f4229f89c3b42c4b642c1266106bdb0 |
| institution | Directory Open Access Journal |
| issn | 1746-1596 |
| language | English |
| last_indexed | 2024-12-15T00:47:16Z |
| publishDate | 2020-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Diagnostic Pathology |
| spelling | doaj.art-9f4229f89c3b42c4b642c1266106bdb02022-12-21T22:41:31ZengBMCDiagnostic Pathology1746-15962020-02-011511810.1186/s13000-020-00933-zClinicopathological features of primary thyroid Burkitt’s lymphoma: a systematic review and meta-analysisToshitetsu Hayashi0Mitsuyoshi Hirokawa1Seiji Kuma2Miyoko Higuchi3Ayana Suzuki4Risa Kanematsu5Takumi Kudo6Naomi Katsuki7Reiji Haba8Akira Miyauchi9Department of Diagnostic Pathology and Cytology, Kuma HospitalDepartment of Diagnostic Pathology and Cytology, Kuma HospitalDepartment of Diagnostic Pathology and Cytology, Kuma HospitalDepartment of Diagnostic Pathology and Cytology, Kuma HospitalDepartment of Diagnostic Pathology and Cytology, Kuma HospitalDepartment of Diagnostic Pathology and Cytology, Kuma HospitalDepartment of Internal Medicine, Kuma HospitalDepartment of Diagnostic Pathology, Takamatsu Red Cross HospitalDepartment of Diagnostic Pathology, Faculty of Medicine, Kagawa UniversityDepartment of Surgery, Kuma HospitalAbstract Background Primary thyroid Burkitt’s lymphoma (BL) is an extremely rare and highly aggressive form of non-Hodgkin’s lymphoma; only isolated case reports are available for patients with this disease. Methods We analyzed the clinicopathological features of thyroid BL by conducting a meta-analysis of 21 known patients (including ours) and compared them to those of extrathyroidal BL. Results There were 13 men and 8 women with a median age of 39.3 years (range, 6–75 years). The median follow-up was 46.5 months (range, 0.5–361 months). Six patients (28.6%) had stage I disease, 2 (9.5%) had stage II, 2 (9.5%) had stage III, and 11 (52.4%) had stage IV. Five of 7 tested patients with thyroid BL (71.4%) had histological evidence of underlying Hashimoto’s thyroiditis. Ki-67 labeling indices exceeding 90% in all 19 patients tested (100%). Fluorescence in situ hybridization performed on 12 patient samples revealed that all (100%) had MYC rearrangement. Among the 16 patients for whom follow-up data were available, 4 died of disease-related causes. Kaplan-Meier analysis revealed that the 12- and 60-month overall survival rates for patients with thyroid BL were 87.5 and 70.7%, respectively. Conclusions Ours was the largest study of thyroid BL and its detailed clinicopathological features to date. Thyroid BL is not associated with underlying Epstein-Barr virus infection but is closely linked to Hashimoto’s thyroiditis; patients generally have good overall survival and respond well to intensive chemotherapy. The correct pathological diagnosis is essential for treatment selection and outcome improvement.https://doi.org/10.1186/s13000-020-00933-zThyroid Burkitt’s lymphomaHashimoto’s thyroiditisMeta-analysisClinicopathological features |
| spellingShingle | Toshitetsu Hayashi Mitsuyoshi Hirokawa Seiji Kuma Miyoko Higuchi Ayana Suzuki Risa Kanematsu Takumi Kudo Naomi Katsuki Reiji Haba Akira Miyauchi Clinicopathological features of primary thyroid Burkitt’s lymphoma: a systematic review and meta-analysis Diagnostic Pathology Thyroid Burkitt’s lymphoma Hashimoto’s thyroiditis Meta-analysis Clinicopathological features |
| title | Clinicopathological features of primary thyroid Burkitt’s lymphoma: a systematic review and meta-analysis |
| title_full | Clinicopathological features of primary thyroid Burkitt’s lymphoma: a systematic review and meta-analysis |
| title_fullStr | Clinicopathological features of primary thyroid Burkitt’s lymphoma: a systematic review and meta-analysis |
| title_full_unstemmed | Clinicopathological features of primary thyroid Burkitt’s lymphoma: a systematic review and meta-analysis |
| title_short | Clinicopathological features of primary thyroid Burkitt’s lymphoma: a systematic review and meta-analysis |
| title_sort | clinicopathological features of primary thyroid burkitt s lymphoma a systematic review and meta analysis |
| topic | Thyroid Burkitt’s lymphoma Hashimoto’s thyroiditis Meta-analysis Clinicopathological features |
| url | https://doi.org/10.1186/s13000-020-00933-z |
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