Impact of TP53 mutations in Triple Negative Breast Cancer

Impact of TP53 mutations in Triple Negative Breast Cancer

Abstract Identifying triple negative breast cancer (TNBC) patients expected to have poor outcomes provides an opportunity to enhance clinical management. We applied an Evolutionary Action Score to functionally characterize TP53 mutations (EAp53) in 96 TNBC patients and observed that EAp53 stratifica...

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Bibliographic Details
Main Authors: Zahi I. Mitri, Nour Abuhadra, Shaun M. Goodyear, Evthokia A. Hobbs, Andy Kaempf, Alastair M. Thompson, Stacy L. Moulder
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-022-00303-6
Description
Summary:Abstract Identifying triple negative breast cancer (TNBC) patients expected to have poor outcomes provides an opportunity to enhance clinical management. We applied an Evolutionary Action Score to functionally characterize TP53 mutations (EAp53) in 96 TNBC patients and observed that EAp53 stratification may identify TP53 mutations associated with worse outcomes. These findings merit further exploration in larger TNBC cohorts and in patients treated with neoadjuvant chemotherapy regimens.
ISSN:2397-768X

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