Impact of TP53 mutations in Triple Negative Breast Cancer
Abstract Identifying triple negative breast cancer (TNBC) patients expected to have poor outcomes provides an opportunity to enhance clinical management. We applied an Evolutionary Action Score to functionally characterize TP53 mutations (EAp53) in 96 TNBC patients and observed that EAp53 stratifica...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-09-01
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| Series: | npj Precision Oncology |
| Online Access: | https://doi.org/10.1038/s41698-022-00303-6 |
| _version_ | 1827776102881296384 |
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| author | Zahi I. Mitri Nour Abuhadra Shaun M. Goodyear Evthokia A. Hobbs Andy Kaempf Alastair M. Thompson Stacy L. Moulder |
| author_facet | Zahi I. Mitri Nour Abuhadra Shaun M. Goodyear Evthokia A. Hobbs Andy Kaempf Alastair M. Thompson Stacy L. Moulder |
| author_sort | Zahi I. Mitri |
| collection | DOAJ |
| description | Abstract Identifying triple negative breast cancer (TNBC) patients expected to have poor outcomes provides an opportunity to enhance clinical management. We applied an Evolutionary Action Score to functionally characterize TP53 mutations (EAp53) in 96 TNBC patients and observed that EAp53 stratification may identify TP53 mutations associated with worse outcomes. These findings merit further exploration in larger TNBC cohorts and in patients treated with neoadjuvant chemotherapy regimens. |
| first_indexed | 2024-03-11T13:59:22Z |
| format | Article |
| id | doaj.art-9f43d2c137084c2b949a03adf0c1d3b4 |
| institution | Directory Open Access Journal |
| issn | 2397-768X |
| language | English |
| last_indexed | 2024-03-11T13:59:22Z |
| publishDate | 2022-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Precision Oncology |
| spelling | doaj.art-9f43d2c137084c2b949a03adf0c1d3b42023-11-02T05:15:36ZengNature Portfolionpj Precision Oncology2397-768X2022-09-01611510.1038/s41698-022-00303-6Impact of TP53 mutations in Triple Negative Breast CancerZahi I. Mitri0Nour Abuhadra1Shaun M. Goodyear2Evthokia A. Hobbs3Andy Kaempf4Alastair M. Thompson5Stacy L. Moulder6Knight Cancer Institute, Oregon Health & Science UniversityMemorial Sloan Kettering Cancer CenterKnight Cancer Institute, Oregon Health & Science UniversityKnight Cancer Institute, Oregon Health & Science UniversityKnight Cancer Institute, Oregon Health & Science UniversityBaylor College of MedicineEli Lilly and CompanyAbstract Identifying triple negative breast cancer (TNBC) patients expected to have poor outcomes provides an opportunity to enhance clinical management. We applied an Evolutionary Action Score to functionally characterize TP53 mutations (EAp53) in 96 TNBC patients and observed that EAp53 stratification may identify TP53 mutations associated with worse outcomes. These findings merit further exploration in larger TNBC cohorts and in patients treated with neoadjuvant chemotherapy regimens.https://doi.org/10.1038/s41698-022-00303-6 |
| spellingShingle | Zahi I. Mitri Nour Abuhadra Shaun M. Goodyear Evthokia A. Hobbs Andy Kaempf Alastair M. Thompson Stacy L. Moulder Impact of TP53 mutations in Triple Negative Breast Cancer npj Precision Oncology |
| title | Impact of TP53 mutations in Triple Negative Breast Cancer |
| title_full | Impact of TP53 mutations in Triple Negative Breast Cancer |
| title_fullStr | Impact of TP53 mutations in Triple Negative Breast Cancer |
| title_full_unstemmed | Impact of TP53 mutations in Triple Negative Breast Cancer |
| title_short | Impact of TP53 mutations in Triple Negative Breast Cancer |
| title_sort | impact of tp53 mutations in triple negative breast cancer |
| url | https://doi.org/10.1038/s41698-022-00303-6 |
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