Short-term versus long-term mentalization-based therapy for outpatients with subthreshold or diagnosed borderline personality disorder: a protocol for a randomized clinical trial
Abstract Background Psychotherapy for borderline personality disorder is often lengthy and resource-intensive. However, the current length of outpatient treatments is arbitrary and based on trials that never tested if the treatment intensity could be reduced. As a result, there is insufficient evide...
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| Format: | Article |
| Language: | English |
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BMC
2019-04-01
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| Series: | Trials |
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| Online Access: | http://link.springer.com/article/10.1186/s13063-019-3306-7 |
| _version_ | 1818913004015583232 |
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| author | Sophie Juul Susanne Lunn Stig Poulsen Per Sørensen Mehrak Salimi Janus Christian Jakobsen Anthony Bateman Sebastian Simonsen |
| author_facet | Sophie Juul Susanne Lunn Stig Poulsen Per Sørensen Mehrak Salimi Janus Christian Jakobsen Anthony Bateman Sebastian Simonsen |
| author_sort | Sophie Juul |
| collection | DOAJ |
| description | Abstract Background Psychotherapy for borderline personality disorder is often lengthy and resource-intensive. However, the current length of outpatient treatments is arbitrary and based on trials that never tested if the treatment intensity could be reduced. As a result, there is insufficient evidence to inform the decision between short-term and long-term psychotherapy for borderline personality disorder. Mentalization-based therapy is one treatment option for borderline personality disorder and consists traditionally of an 18-month treatment program. Methods/design This trial is an investigator-initiated single-center randomized clinical superiority trial of short-term (20 weeks) compared to long-term (14 months) mentalization-based therapy for outpatients with subthreshold or diagnosed borderline personality disorder. Participants will be recruited from the Outpatient Clinic for Personality Disorders at Stolpegaard Psychotherapy Centre, Mental Health Services, Capital Region of Denmark. Participants will be included if they meet a minimum of four DSM-V criteria for borderline personality disorder. Participants will be assessed before randomization, and at 8, 16, and 24 months after randomization. The primary outcome is severity of borderline symptomatology assessed with the Zanarini Rating Scale for borderline personality disorder. Secondary outcomes include self-harm incidents, functional impairment (Work and Social Adjustment Scale, Global Assessment of Functioning) and quality of life (Short-Form Health Survey 36). Severity of psychiatric symptoms (Symptom Checklist 90-R) will be included as an exploratory outcome. Measures of personality functioning, attachment, borderline symptoms, group alliance, and mentalization skills will be included to explore potential predictors and mechanisms of change. Discussion This trial will provide evidence of the beneficial and harmful effects of short-term compared to long-term mentalization-based therapy for outpatients with subthreshold or diagnosed borderline personality disorder. Trial registration ClinicalTrials.gov, NCT03677037. Registered on September 19, 2018. |
| first_indexed | 2024-12-19T23:23:35Z |
| format | Article |
| id | doaj.art-9f4bcec542084dbc86ebd917747690cb |
| institution | Directory Open Access Journal |
| issn | 1745-6215 |
| language | English |
| last_indexed | 2024-12-19T23:23:35Z |
| publishDate | 2019-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Trials |
| spelling | doaj.art-9f4bcec542084dbc86ebd917747690cb2022-12-21T20:01:54ZengBMCTrials1745-62152019-04-0120111010.1186/s13063-019-3306-7Short-term versus long-term mentalization-based therapy for outpatients with subthreshold or diagnosed borderline personality disorder: a protocol for a randomized clinical trialSophie Juul0Susanne Lunn1Stig Poulsen2Per Sørensen3Mehrak Salimi4Janus Christian Jakobsen5Anthony Bateman6Sebastian Simonsen7Stolpegaard Psychotherapy Centre, Mental Health ServicesDepartment of Psychology, University of CopenhagenDepartment of Psychology, University of CopenhagenStolpegaard Psychotherapy Centre, Mental Health ServicesStolpegaard Psychotherapy Centre, Mental Health ServicesCopenhagen Trial Unit, Center for Clinical Intervention Research, Rigshospitalet, Copenhagen University HospitalSt. Anns HospitalStolpegaard Psychotherapy Centre, Mental Health ServicesAbstract Background Psychotherapy for borderline personality disorder is often lengthy and resource-intensive. However, the current length of outpatient treatments is arbitrary and based on trials that never tested if the treatment intensity could be reduced. As a result, there is insufficient evidence to inform the decision between short-term and long-term psychotherapy for borderline personality disorder. Mentalization-based therapy is one treatment option for borderline personality disorder and consists traditionally of an 18-month treatment program. Methods/design This trial is an investigator-initiated single-center randomized clinical superiority trial of short-term (20 weeks) compared to long-term (14 months) mentalization-based therapy for outpatients with subthreshold or diagnosed borderline personality disorder. Participants will be recruited from the Outpatient Clinic for Personality Disorders at Stolpegaard Psychotherapy Centre, Mental Health Services, Capital Region of Denmark. Participants will be included if they meet a minimum of four DSM-V criteria for borderline personality disorder. Participants will be assessed before randomization, and at 8, 16, and 24 months after randomization. The primary outcome is severity of borderline symptomatology assessed with the Zanarini Rating Scale for borderline personality disorder. Secondary outcomes include self-harm incidents, functional impairment (Work and Social Adjustment Scale, Global Assessment of Functioning) and quality of life (Short-Form Health Survey 36). Severity of psychiatric symptoms (Symptom Checklist 90-R) will be included as an exploratory outcome. Measures of personality functioning, attachment, borderline symptoms, group alliance, and mentalization skills will be included to explore potential predictors and mechanisms of change. Discussion This trial will provide evidence of the beneficial and harmful effects of short-term compared to long-term mentalization-based therapy for outpatients with subthreshold or diagnosed borderline personality disorder. Trial registration ClinicalTrials.gov, NCT03677037. Registered on September 19, 2018.http://link.springer.com/article/10.1186/s13063-019-3306-7Mentalization-based therapyBorderline personality disorderRandomized clinical trialTreatment intensity |
| spellingShingle | Sophie Juul Susanne Lunn Stig Poulsen Per Sørensen Mehrak Salimi Janus Christian Jakobsen Anthony Bateman Sebastian Simonsen Short-term versus long-term mentalization-based therapy for outpatients with subthreshold or diagnosed borderline personality disorder: a protocol for a randomized clinical trial Trials Mentalization-based therapy Borderline personality disorder Randomized clinical trial Treatment intensity |
| title | Short-term versus long-term mentalization-based therapy for outpatients with subthreshold or diagnosed borderline personality disorder: a protocol for a randomized clinical trial |
| title_full | Short-term versus long-term mentalization-based therapy for outpatients with subthreshold or diagnosed borderline personality disorder: a protocol for a randomized clinical trial |
| title_fullStr | Short-term versus long-term mentalization-based therapy for outpatients with subthreshold or diagnosed borderline personality disorder: a protocol for a randomized clinical trial |
| title_full_unstemmed | Short-term versus long-term mentalization-based therapy for outpatients with subthreshold or diagnosed borderline personality disorder: a protocol for a randomized clinical trial |
| title_short | Short-term versus long-term mentalization-based therapy for outpatients with subthreshold or diagnosed borderline personality disorder: a protocol for a randomized clinical trial |
| title_sort | short term versus long term mentalization based therapy for outpatients with subthreshold or diagnosed borderline personality disorder a protocol for a randomized clinical trial |
| topic | Mentalization-based therapy Borderline personality disorder Randomized clinical trial Treatment intensity |
| url | http://link.springer.com/article/10.1186/s13063-019-3306-7 |
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