The Role of NADPH Oxidase in Neuronal Death and Neurogenesis after Acute Neurological Disorders
Oxidative stress is a well-known common pathological process involved in mediating acute neurological injuries, such as stroke, traumatic brain injury, epilepsy, and hypoglycemia-related neuronal injury. However, effective therapeutic measures aimed at scavenging free reactive oxygen species have sh...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/10/5/739 |
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| author | Song Hee Lee Minwoo Lee Dong Gyun Ko Bo Young Choi Sang Won Suh |
| author_facet | Song Hee Lee Minwoo Lee Dong Gyun Ko Bo Young Choi Sang Won Suh |
| author_sort | Song Hee Lee |
| collection | DOAJ |
| description | Oxidative stress is a well-known common pathological process involved in mediating acute neurological injuries, such as stroke, traumatic brain injury, epilepsy, and hypoglycemia-related neuronal injury. However, effective therapeutic measures aimed at scavenging free reactive oxygen species have shown little success in clinical trials. Recent studies have revealed that NADPH oxidase, a membrane-bound enzyme complex that catalyzes the production of a superoxide free radical, is one of the major sources of cellular reactive oxygen species in acute neurological disorders. Furthermore, several studies, including our previous ones, have shown that the inhibition of NADPH oxidase can reduce subsequent neuronal injury in neurological disease. Moreover, maintaining appropriate levels of NADPH oxidase has also been shown to be associated with proper neurogenesis after neuronal injury. This review aims to present a comprehensive overview of the role of NADPH oxidase in neuronal death and neurogenesis in multiple acute neurological disorders and to explore potential pharmacological strategies targeting the NADPH-related oxidative stress pathways. |
| first_indexed | 2024-03-10T11:38:46Z |
| format | Article |
| id | doaj.art-9f4bec79130e49e6bb67da1e8fddcadc |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T11:38:46Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-9f4bec79130e49e6bb67da1e8fddcadc2023-11-21T18:39:42ZengMDPI AGAntioxidants2076-39212021-05-0110573910.3390/antiox10050739The Role of NADPH Oxidase in Neuronal Death and Neurogenesis after Acute Neurological DisordersSong Hee Lee0Minwoo Lee1Dong Gyun Ko2Bo Young Choi3Sang Won Suh4Department of Physiology, College of Medicine, Hallym University, Chuncheon 24252, KoreaDepartment of Physiology, College of Medicine, Hallym University, Chuncheon 24252, KoreaDepartment of Physiology, College of Medicine, Hallym University, Chuncheon 24252, KoreaDepartment of Physiology, College of Medicine, Hallym University, Chuncheon 24252, KoreaDepartment of Physiology, College of Medicine, Hallym University, Chuncheon 24252, KoreaOxidative stress is a well-known common pathological process involved in mediating acute neurological injuries, such as stroke, traumatic brain injury, epilepsy, and hypoglycemia-related neuronal injury. However, effective therapeutic measures aimed at scavenging free reactive oxygen species have shown little success in clinical trials. Recent studies have revealed that NADPH oxidase, a membrane-bound enzyme complex that catalyzes the production of a superoxide free radical, is one of the major sources of cellular reactive oxygen species in acute neurological disorders. Furthermore, several studies, including our previous ones, have shown that the inhibition of NADPH oxidase can reduce subsequent neuronal injury in neurological disease. Moreover, maintaining appropriate levels of NADPH oxidase has also been shown to be associated with proper neurogenesis after neuronal injury. This review aims to present a comprehensive overview of the role of NADPH oxidase in neuronal death and neurogenesis in multiple acute neurological disorders and to explore potential pharmacological strategies targeting the NADPH-related oxidative stress pathways.https://www.mdpi.com/2076-3921/10/5/739NADPH oxidaseneuronal deathneurogenesisstroketraumatic brain injuryepilepsy |
| spellingShingle | Song Hee Lee Minwoo Lee Dong Gyun Ko Bo Young Choi Sang Won Suh The Role of NADPH Oxidase in Neuronal Death and Neurogenesis after Acute Neurological Disorders Antioxidants NADPH oxidase neuronal death neurogenesis stroke traumatic brain injury epilepsy |
| title | The Role of NADPH Oxidase in Neuronal Death and Neurogenesis after Acute Neurological Disorders |
| title_full | The Role of NADPH Oxidase in Neuronal Death and Neurogenesis after Acute Neurological Disorders |
| title_fullStr | The Role of NADPH Oxidase in Neuronal Death and Neurogenesis after Acute Neurological Disorders |
| title_full_unstemmed | The Role of NADPH Oxidase in Neuronal Death and Neurogenesis after Acute Neurological Disorders |
| title_short | The Role of NADPH Oxidase in Neuronal Death and Neurogenesis after Acute Neurological Disorders |
| title_sort | role of nadph oxidase in neuronal death and neurogenesis after acute neurological disorders |
| topic | NADPH oxidase neuronal death neurogenesis stroke traumatic brain injury epilepsy |
| url | https://www.mdpi.com/2076-3921/10/5/739 |
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