Ginsenosides in cancer: A focus on the regulation of cell metabolism
Metabolic alterations play a key role in promoting tumor initiation and progression, leading to extensive tumor heterogeneity and adaptability. Thus, targeting abnormal metabolic processes is a promising novel approach for cancer treatment. Numerous pharmacological studies have indicated that many t...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332222011453 |
| _version_ | 1811308641905541120 |
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| author | Wang Yao Yunfeng Guan |
| author_facet | Wang Yao Yunfeng Guan |
| author_sort | Wang Yao |
| collection | DOAJ |
| description | Metabolic alterations play a key role in promoting tumor initiation and progression, leading to extensive tumor heterogeneity and adaptability. Thus, targeting abnormal metabolic processes is a promising novel approach for cancer treatment. Numerous pharmacological studies have indicated that many traditional Chinese medicines possess remarkable antitumor activities. Ginsenosides, the main bioactive ingredients of Panax and other types of ginseng, exert beneficial antitumor effects, in addition to the anti-inflammation, anti-oxidant, and anti-fatigue effects. Recently, considerable attention has been paid to the regulation of cancer cell metabolism by ginsenosides. Here, we summarize the structural characteristics and classification of ginsenosides, their antitumor mechanisms, recent progress and the achievements of ginsenoside research in modulating cancer cell metabolism, including the diverse metabolic processes and their regulatory processes, as well as the opportunities and challenges of strategies targeting metabolic vulnerabilities. This review provides novel perspectives on the potential applications of ginsenosides that exert antitumor effects by reshaping cancer metabolism. |
| first_indexed | 2024-04-13T09:26:56Z |
| format | Article |
| id | doaj.art-9f4e4e1c4e924ea09ffef9a8633ee857 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-13T09:26:56Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-9f4e4e1c4e924ea09ffef9a8633ee8572022-12-22T02:52:24ZengElsevierBiomedicine & Pharmacotherapy0753-33222022-12-01156113756Ginsenosides in cancer: A focus on the regulation of cell metabolismWang Yao0Yunfeng Guan1Academy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Medical Oncology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Correspondence to: Department of Medical Oncology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.Metabolic alterations play a key role in promoting tumor initiation and progression, leading to extensive tumor heterogeneity and adaptability. Thus, targeting abnormal metabolic processes is a promising novel approach for cancer treatment. Numerous pharmacological studies have indicated that many traditional Chinese medicines possess remarkable antitumor activities. Ginsenosides, the main bioactive ingredients of Panax and other types of ginseng, exert beneficial antitumor effects, in addition to the anti-inflammation, anti-oxidant, and anti-fatigue effects. Recently, considerable attention has been paid to the regulation of cancer cell metabolism by ginsenosides. Here, we summarize the structural characteristics and classification of ginsenosides, their antitumor mechanisms, recent progress and the achievements of ginsenoside research in modulating cancer cell metabolism, including the diverse metabolic processes and their regulatory processes, as well as the opportunities and challenges of strategies targeting metabolic vulnerabilities. This review provides novel perspectives on the potential applications of ginsenosides that exert antitumor effects by reshaping cancer metabolism.http://www.sciencedirect.com/science/article/pii/S0753332222011453GinsenosidesCancerCell metabolismAntitumor activityMechanism |
| spellingShingle | Wang Yao Yunfeng Guan Ginsenosides in cancer: A focus on the regulation of cell metabolism Biomedicine & Pharmacotherapy Ginsenosides Cancer Cell metabolism Antitumor activity Mechanism |
| title | Ginsenosides in cancer: A focus on the regulation of cell metabolism |
| title_full | Ginsenosides in cancer: A focus on the regulation of cell metabolism |
| title_fullStr | Ginsenosides in cancer: A focus on the regulation of cell metabolism |
| title_full_unstemmed | Ginsenosides in cancer: A focus on the regulation of cell metabolism |
| title_short | Ginsenosides in cancer: A focus on the regulation of cell metabolism |
| title_sort | ginsenosides in cancer a focus on the regulation of cell metabolism |
| topic | Ginsenosides Cancer Cell metabolism Antitumor activity Mechanism |
| url | http://www.sciencedirect.com/science/article/pii/S0753332222011453 |
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