Bioluminescence Detection of Cells Having Stabilized p53 in Response to a Genotoxic Event
Inactivation of p53 is one of the most frequent molecular events in neoplastic transformation. Approximately 60% of all human tumors have mutations in both p53 alleles. Wild-type p53 activity is regulated in large part by the proteosome-dependent degradation of p53, resulting in a short p53 half-lif...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2004-01-01
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| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.1162/15353500200403175 |