Effect of combination antihypertensive therapy on the endothelial function in women with hypertension in perimenopause
The study covered 109 female patients with 1-2 degree hypertension in perimenopause and daily evaluated the results of 24-hour blood pressure monitoring, endothelial function using endothelium-dependent and endothelium-dependent vasodilation of the brachial artery, and endothelin-1 concentration in...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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Remedium Group LLC
2013-12-01
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| Series: | Медицинский совет |
| Subjects: | |
| Online Access: | https://www.med-sovet.pro/jour/article/view/965 |
| _version_ | 1797841646144978944 |
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| author | Y. V. Brytkova I. S. Gomova O. V. Tatarinova R. I. Stryuk |
| author_facet | Y. V. Brytkova I. S. Gomova O. V. Tatarinova R. I. Stryuk |
| author_sort | Y. V. Brytkova |
| collection | DOAJ |
| description | The study covered 109 female patients with 1-2 degree hypertension in perimenopause and daily evaluated the results of 24-hour blood pressure monitoring, endothelial function using endothelium-dependent and endothelium-dependent vasodilation of the brachial artery, and endothelin-1 concentration in blood serum before treatment and after 12 weeks of monotherapy with ramipril ACE inhibitor (7 people), losartan angiotensin II receptor blocker (8 people) or combination of ramipril with Lodoz (45 people) and losartan with Lodoz (49 people). In all the observed groups, blood pressure decrease to recommended levels and an improvement of endothelial function were achieved; the latter was manifested in the positive decrease of endothelin-1 concentration in the serum which was high in comparison with reference values already in 1 degree AH, and in the improvement of vasodilator properties in the shoulder artery. |
| first_indexed | 2024-04-09T16:34:43Z |
| format | Article |
| id | doaj.art-9f5424d1a0664da0be8f715d043ec4a5 |
| institution | Directory Open Access Journal |
| issn | 2079-701X 2658-5790 |
| language | Russian |
| last_indexed | 2024-04-09T16:34:43Z |
| publishDate | 2013-12-01 |
| publisher | Remedium Group LLC |
| record_format | Article |
| series | Медицинский совет |
| spelling | doaj.art-9f5424d1a0664da0be8f715d043ec4a52023-04-23T06:56:58ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902013-12-0103-2626810.21518/2079-701X-2013-3-2-62-68965Effect of combination antihypertensive therapy on the endothelial function in women with hypertension in perimenopauseY. V. Brytkova0I. S. Gomova1O. V. Tatarinova2R. I. Stryuk3Moscow State University of Medicine and Dentistry named after A.I. Evdokimov, Russia’s Ministry of HealthMoscow State University of Medicine and Dentistry named after A.I. Evdokimov, Russia’s Ministry of HealthMoscow State University of Medicine and Dentistry named after A.I. Evdokimov, Russia’s Ministry of HealthMoscow State University of Medicine and Dentistry named after A.I. Evdokimov, Russia’s Ministry of HealthThe study covered 109 female patients with 1-2 degree hypertension in perimenopause and daily evaluated the results of 24-hour blood pressure monitoring, endothelial function using endothelium-dependent and endothelium-dependent vasodilation of the brachial artery, and endothelin-1 concentration in blood serum before treatment and after 12 weeks of monotherapy with ramipril ACE inhibitor (7 people), losartan angiotensin II receptor blocker (8 people) or combination of ramipril with Lodoz (45 people) and losartan with Lodoz (49 people). In all the observed groups, blood pressure decrease to recommended levels and an improvement of endothelial function were achieved; the latter was manifested in the positive decrease of endothelin-1 concentration in the serum which was high in comparison with reference values already in 1 degree AH, and in the improvement of vasodilator properties in the shoulder artery.https://www.med-sovet.pro/jour/article/view/965артериальная гипертонияженщины в перименопаузевазодилатирующая функция эндотелияэндотелиальная дисфункцияэндотелин-1рамиприллозартанлодозhypertensionwomen in perimenopausevasodilator endothelial functionendothelial dysfunctionendothelin-1ramiprillosartanlodoz |
| spellingShingle | Y. V. Brytkova I. S. Gomova O. V. Tatarinova R. I. Stryuk Effect of combination antihypertensive therapy on the endothelial function in women with hypertension in perimenopause Медицинский совет артериальная гипертония женщины в перименопаузе вазодилатирующая функция эндотелия эндотелиальная дисфункция эндотелин-1 рамиприл лозартан лодоз hypertension women in perimenopause vasodilator endothelial function endothelial dysfunction endothelin-1 ramipril losartan lodoz |
| title | Effect of combination antihypertensive therapy on the endothelial function in women with hypertension in perimenopause |
| title_full | Effect of combination antihypertensive therapy on the endothelial function in women with hypertension in perimenopause |
| title_fullStr | Effect of combination antihypertensive therapy on the endothelial function in women with hypertension in perimenopause |
| title_full_unstemmed | Effect of combination antihypertensive therapy on the endothelial function in women with hypertension in perimenopause |
| title_short | Effect of combination antihypertensive therapy on the endothelial function in women with hypertension in perimenopause |
| title_sort | effect of combination antihypertensive therapy on the endothelial function in women with hypertension in perimenopause |
| topic | артериальная гипертония женщины в перименопаузе вазодилатирующая функция эндотелия эндотелиальная дисфункция эндотелин-1 рамиприл лозартан лодоз hypertension women in perimenopause vasodilator endothelial function endothelial dysfunction endothelin-1 ramipril losartan lodoz |
| url | https://www.med-sovet.pro/jour/article/view/965 |
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