Targeted photoimmunotherapy for cancer
Photodynamic therapy (PDT) is a clinically approved procedure that can exert a curative action against malignant cells. The treatment implies the administration of a photoactive molecular species that, upon absorption of visible or near infrared light, sensitizes the formation of reactive oxygen spe...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2022-03-01
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| Series: | Biomolecular Concepts |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/bmc-2022-0010 |
| _version_ | 1811236706741911552 |
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| author | Mussini Andrea Uriati Eleonora Bianchini Paolo Diaspro Alberto Cavanna Luigi Abbruzzetti Stefania Viappiani Cristiano |
| author_facet | Mussini Andrea Uriati Eleonora Bianchini Paolo Diaspro Alberto Cavanna Luigi Abbruzzetti Stefania Viappiani Cristiano |
| author_sort | Mussini Andrea |
| collection | DOAJ |
| description | Photodynamic therapy (PDT) is a clinically approved procedure that can exert a curative action against malignant cells. The treatment implies the administration of a photoactive molecular species that, upon absorption of visible or near infrared light, sensitizes the formation of reactive oxygen species. These species are cytotoxic and lead to tumor cell death, damage vasculature, and induce inflammation. Clinical investigations demonstrated that PDT is curative and does not compromise other treatment options. One of the major limitations of the original method was the low selectivity of the photoactive compounds for malignant over healthy tissues. The development of conjugates with antibodies has endowed photosensitizing molecules with targeting capability, so that the compounds are delivered with unprecedented precision to the site of action. Given their fluorescence emission capability, these supramolecular species are intrinsically theranostic agents. |
| first_indexed | 2024-04-12T12:12:38Z |
| format | Article |
| id | doaj.art-9f542e7cdcd2486789cd506803acad26 |
| institution | Directory Open Access Journal |
| issn | 1868-503X |
| language | English |
| last_indexed | 2024-04-12T12:12:38Z |
| publishDate | 2022-03-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Biomolecular Concepts |
| spelling | doaj.art-9f542e7cdcd2486789cd506803acad262022-12-22T03:33:32ZengDe GruyterBiomolecular Concepts1868-503X2022-03-0113112614710.1515/bmc-2022-0010Targeted photoimmunotherapy for cancerMussini Andrea0Uriati Eleonora1Bianchini Paolo2Diaspro Alberto3Cavanna Luigi4Abbruzzetti Stefania5Viappiani Cristiano6Dipartimento di Scienze Matematiche, Fisiche e Informatiche, Università Degli Studi di Parma, Parma, ItalyDipartimento di Scienze Matematiche, Fisiche e Informatiche, Università Degli Studi di Parma, Parma, ItalyDipartimento di Scienze Matematiche, Fisiche e Informatiche, Università Degli Studi di Parma, Parma, ItalyDepartment of Nanophysics, Nanoscopy, Istituto Italiano di Tecnologia, Genova, ItalyDipartimento di Oncologia-Ematologia, Azienda USL di Piacenza, Piacenza, ItalyDipartimento di Scienze Matematiche, Fisiche e Informatiche, Università Degli Studi di Parma, Parma, ItalyDipartimento di Scienze Matematiche, Fisiche e Informatiche, Università Degli Studi di Parma, Parma, ItalyPhotodynamic therapy (PDT) is a clinically approved procedure that can exert a curative action against malignant cells. The treatment implies the administration of a photoactive molecular species that, upon absorption of visible or near infrared light, sensitizes the formation of reactive oxygen species. These species are cytotoxic and lead to tumor cell death, damage vasculature, and induce inflammation. Clinical investigations demonstrated that PDT is curative and does not compromise other treatment options. One of the major limitations of the original method was the low selectivity of the photoactive compounds for malignant over healthy tissues. The development of conjugates with antibodies has endowed photosensitizing molecules with targeting capability, so that the compounds are delivered with unprecedented precision to the site of action. Given their fluorescence emission capability, these supramolecular species are intrinsically theranostic agents.https://doi.org/10.1515/bmc-2022-0010targeted photodynamic therapycancerantibodyphotosensitizerreactive oxygen speciesfluorescence |
| spellingShingle | Mussini Andrea Uriati Eleonora Bianchini Paolo Diaspro Alberto Cavanna Luigi Abbruzzetti Stefania Viappiani Cristiano Targeted photoimmunotherapy for cancer Biomolecular Concepts targeted photodynamic therapy cancer antibody photosensitizer reactive oxygen species fluorescence |
| title | Targeted photoimmunotherapy for cancer |
| title_full | Targeted photoimmunotherapy for cancer |
| title_fullStr | Targeted photoimmunotherapy for cancer |
| title_full_unstemmed | Targeted photoimmunotherapy for cancer |
| title_short | Targeted photoimmunotherapy for cancer |
| title_sort | targeted photoimmunotherapy for cancer |
| topic | targeted photodynamic therapy cancer antibody photosensitizer reactive oxygen species fluorescence |
| url | https://doi.org/10.1515/bmc-2022-0010 |
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