Changes in clinical indicators among human immunodeficiency virus patients who failed in antiretroviral therapy during 2004–2016 in Yunnan, China: an observational cohort study
Background: This study aimed to investigate the changes in the clinical indicators and influencing factors of treatment duration among human immunodeficiency virus (HIV) patients in whom antiretroviral therapy (ART) was unsuccessful. Methods: In this retrospective study, a total of 9,418 HIV patient...
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KeAi Communications Co., Ltd.
2020-06-01
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| Series: | Global Health Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2414644720300191 |
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| author | Peicheng Wang Junfang Xu Bingbing Guo Jason K. Wang Liangmin Gao Qianyun Wang Jun Jing Feng Cheng |
| author_facet | Peicheng Wang Junfang Xu Bingbing Guo Jason K. Wang Liangmin Gao Qianyun Wang Jun Jing Feng Cheng |
| author_sort | Peicheng Wang |
| collection | DOAJ |
| description | Background: This study aimed to investigate the changes in the clinical indicators and influencing factors of treatment duration among human immunodeficiency virus (HIV) patients in whom antiretroviral therapy (ART) was unsuccessful. Methods: In this retrospective study, a total of 9,418 HIV patients who failed in ART during 2004–2016 were included and divided into two treatment groups—Group 1 (treatment time ≤3 years, n1 = 5,218) and Group 2 (treatment time > 3 years, n2 = 4,200). Patient follow-up data, including age, cluster of differentiation 4 (CD4) count, and viral load, glucose, creatinine, and triglyceride levels, were extracted from electronic health record databases. Covariance analysis for repeated measures was used to analyze the biochemical indicators, and multiple logistic regression modeling was used to compare relevant data extracted from the Group 1 and Group 2 HIV patient cohorts with different treatment time. Results: The median initial CD4 count was 175.0 cells/μl (interquartile range, 77.0–282.0), while the initial CD4 counts for Group 1 were lower than those for Group 2 (P < 0.05). A significant interaction between group and time effects was observed (P < 0.05) in total cholesterol (TC). Changes in hemoglobin level among HIV patients were also significantly associated with treatment time (P = 0.001). The initial CD4 count (odds ratio [OR] = 0.756), female sex (OR = 0.713), Zerit (d4T) (OR = 1.443), TC (OR = 1.285), and aspartate aminotransferase level (OR = 1.002) were significantly associated with the survival time of dead patients with HIV (P < 0.05). Additionally, the initial CD4 count (OR = 1.456), age (OR = 1.022), time interval (OR = 0.903), patient's living status (OR = 0.597), d4T (OR = 2.256), and triglyceride (OR = 0.930) and hemoglobin levels (OR = 0.997) were significantly associated with the treatment time of HIV patients with drug withdrawal (P < 0.05). Conclusion: The initial biochemical parameters can affect the survival and treatment time of HIV patients. With a comprehensive understanding of the physiological and biochemical indicators of patients, we can reduce the probability of drug withdrawal and prolong the survival time of HIV patients. |
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| id | doaj.art-9f5440738f5e440588bdb64c299f4d4a |
| institution | Directory Open Access Journal |
| issn | 2096-3947 |
| language | English |
| last_indexed | 2024-04-10T00:16:51Z |
| publishDate | 2020-06-01 |
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| spelling | doaj.art-9f5440738f5e440588bdb64c299f4d4a2023-03-16T05:05:25ZengKeAi Communications Co., Ltd.Global Health Journal2096-39472020-06-01425763Changes in clinical indicators among human immunodeficiency virus patients who failed in antiretroviral therapy during 2004–2016 in Yunnan, China: an observational cohort studyPeicheng Wang0Junfang Xu1Bingbing Guo2Jason K. Wang3Liangmin Gao4Qianyun Wang5Jun Jing6Feng Cheng7Research Center for Public Health, School of Medicine, Tsinghua University, 30 Shuangqing Road, Beijing 100084, ChinaResearch Institute of Health Policy, School of Public Health, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, ChinaCollege of Life Science and Bioengineering, Beijing University of Technology, 100 Ping Le Yuan, Beijing 100124, ChinaSchwarzman College, Tsinghua University, 30 Shuangqing Road, Beijing 100084, ChinaDepartment of Sociology, Tsinghua University, 30 Shuangqing Road, Beijing 100084, ChinaResearch Center for Public Health, School of Medicine, Tsinghua University, 30 Shuangqing Road, Beijing 100084, ChinaResearch Center for Public Health, School of Medicine, Tsinghua University, 30 Shuangqing Road, Beijing 100084, ChinaResearch Center for Public Health, School of Medicine, Tsinghua University, 30 Shuangqing Road, Beijing 100084, China; Corresponding author.Background: This study aimed to investigate the changes in the clinical indicators and influencing factors of treatment duration among human immunodeficiency virus (HIV) patients in whom antiretroviral therapy (ART) was unsuccessful. Methods: In this retrospective study, a total of 9,418 HIV patients who failed in ART during 2004–2016 were included and divided into two treatment groups—Group 1 (treatment time ≤3 years, n1 = 5,218) and Group 2 (treatment time > 3 years, n2 = 4,200). Patient follow-up data, including age, cluster of differentiation 4 (CD4) count, and viral load, glucose, creatinine, and triglyceride levels, were extracted from electronic health record databases. Covariance analysis for repeated measures was used to analyze the biochemical indicators, and multiple logistic regression modeling was used to compare relevant data extracted from the Group 1 and Group 2 HIV patient cohorts with different treatment time. Results: The median initial CD4 count was 175.0 cells/μl (interquartile range, 77.0–282.0), while the initial CD4 counts for Group 1 were lower than those for Group 2 (P < 0.05). A significant interaction between group and time effects was observed (P < 0.05) in total cholesterol (TC). Changes in hemoglobin level among HIV patients were also significantly associated with treatment time (P = 0.001). The initial CD4 count (odds ratio [OR] = 0.756), female sex (OR = 0.713), Zerit (d4T) (OR = 1.443), TC (OR = 1.285), and aspartate aminotransferase level (OR = 1.002) were significantly associated with the survival time of dead patients with HIV (P < 0.05). Additionally, the initial CD4 count (OR = 1.456), age (OR = 1.022), time interval (OR = 0.903), patient's living status (OR = 0.597), d4T (OR = 2.256), and triglyceride (OR = 0.930) and hemoglobin levels (OR = 0.997) were significantly associated with the treatment time of HIV patients with drug withdrawal (P < 0.05). Conclusion: The initial biochemical parameters can affect the survival and treatment time of HIV patients. With a comprehensive understanding of the physiological and biochemical indicators of patients, we can reduce the probability of drug withdrawal and prolong the survival time of HIV patients.http://www.sciencedirect.com/science/article/pii/S2414644720300191Treatment timeBiochemical indicatorsHIV/AIDSFailure of antiretroviral therapy |
| spellingShingle | Peicheng Wang Junfang Xu Bingbing Guo Jason K. Wang Liangmin Gao Qianyun Wang Jun Jing Feng Cheng Changes in clinical indicators among human immunodeficiency virus patients who failed in antiretroviral therapy during 2004–2016 in Yunnan, China: an observational cohort study Global Health Journal Treatment time Biochemical indicators HIV/AIDS Failure of antiretroviral therapy |
| title | Changes in clinical indicators among human immunodeficiency virus patients who failed in antiretroviral therapy during 2004–2016 in Yunnan, China: an observational cohort study |
| title_full | Changes in clinical indicators among human immunodeficiency virus patients who failed in antiretroviral therapy during 2004–2016 in Yunnan, China: an observational cohort study |
| title_fullStr | Changes in clinical indicators among human immunodeficiency virus patients who failed in antiretroviral therapy during 2004–2016 in Yunnan, China: an observational cohort study |
| title_full_unstemmed | Changes in clinical indicators among human immunodeficiency virus patients who failed in antiretroviral therapy during 2004–2016 in Yunnan, China: an observational cohort study |
| title_short | Changes in clinical indicators among human immunodeficiency virus patients who failed in antiretroviral therapy during 2004–2016 in Yunnan, China: an observational cohort study |
| title_sort | changes in clinical indicators among human immunodeficiency virus patients who failed in antiretroviral therapy during 2004 2016 in yunnan china an observational cohort study |
| topic | Treatment time Biochemical indicators HIV/AIDS Failure of antiretroviral therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2414644720300191 |
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