#247 : Correlation Between the Embryo Morphokinetic Parameters Up To Cleavage Stage and Blastocyst Implantation Capability in Frozen Embryo Transfer Cycles
I. BACKGROUND AND AIMS: Many studies have shown predicted value for embryo development potential or morpho-kinetic parameters. This study aims to determine the correlation between the embryo morpho-kinetic parameters up to the cleavage stage and blastocyst implantation capability in frozen embryo tr...
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Format: | Article |
Language: | English |
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World Scientific Publishing
2023-12-01
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Series: | Fertility & Reproduction |
Online Access: | https://www.worldscientific.com/doi/10.1142/S266131822374211X |
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author | Anh Phi Thi Tu Anh Vu Thi Mai Hop Vu Dinh Huong Nguyen Thi Lien |
author_facet | Anh Phi Thi Tu Anh Vu Thi Mai Hop Vu Dinh Huong Nguyen Thi Lien |
author_sort | Anh Phi Thi Tu |
collection | DOAJ |
description | I. BACKGROUND AND AIMS: Many studies have shown predicted value for embryo development potential or morpho-kinetic parameters. This study aims to determine the correlation between the embryo morpho-kinetic parameters up to the cleavage stage and blastocyst implantation capability in frozen embryo transfer (FET) cycles. II. METHODS: A retrospective cohort study was conducted on 383 good-quality blastocysts of FET cycles from March 2020 to December 2022 at Tam Anh General Hospital. The study evaluated the differences in parameters, including tPNa, tPNf, t2 - t8, cc1, cc2, cc3, s2, s3, and abnormal division (direct, reverse cleavage) between the implant and non-implant groups. Using R’s rpart package, a hierarchical implantation model was created using the decision tree approach. The prognostic value of the model was assessed using ROC. III. RESULTS: 383 blastocysts from 368 FET cycles were examined in our study, of which 222 (57.9%) were implanted and 161 (42.1%) were not. Timing parameters of implanted embryos tended to be longer than that in the non-implanted group, and the division process of blastomeres was more synchronized, however not statistically. Embryos with direct cleavage had a significantly reduced implantation rate compared with non-direct groups (29.0% and 61.0%, p < 0.05) Analysis of morpho-kinetic parameters enabled us to develop a hierarchical model that places the direct cleavage, tPNa, and cc1 as the variables with the best prognosis of implantation. The AUC value of the model was 0.641. IV. CONCLUSION: The study showed that morpho-kinetic parameters at the early division stage have the predictive value of blastocyst implantation and can supplement traditional morphological assessment in embryo selection. |
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issn | 2661-3182 2661-3174 |
language | English |
last_indexed | 2024-04-24T17:13:00Z |
publishDate | 2023-12-01 |
publisher | World Scientific Publishing |
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series | Fertility & Reproduction |
spelling | doaj.art-9f554133819e4fd1beb8bbb34225cc692024-03-28T07:54:19ZengWorld Scientific PublishingFertility & Reproduction2661-31822661-31742023-12-01050442742810.1142/S266131822374211X#247 : Correlation Between the Embryo Morphokinetic Parameters Up To Cleavage Stage and Blastocyst Implantation Capability in Frozen Embryo Transfer CyclesAnh Phi Thi Tu0Anh Vu Thi Mai1Hop Vu Dinh2Huong Nguyen Thi Lien3Tam Anh General Hospital, Hanoi, Hanoi, VietnamTam Anh General Hospital, Hanoi, Hanoi, VietnamTam Anh General Hospital, Hanoi, Hanoi, VietnamTam Anh General Hospital, Hanoi, Hanoi, VietnamI. BACKGROUND AND AIMS: Many studies have shown predicted value for embryo development potential or morpho-kinetic parameters. This study aims to determine the correlation between the embryo morpho-kinetic parameters up to the cleavage stage and blastocyst implantation capability in frozen embryo transfer (FET) cycles. II. METHODS: A retrospective cohort study was conducted on 383 good-quality blastocysts of FET cycles from March 2020 to December 2022 at Tam Anh General Hospital. The study evaluated the differences in parameters, including tPNa, tPNf, t2 - t8, cc1, cc2, cc3, s2, s3, and abnormal division (direct, reverse cleavage) between the implant and non-implant groups. Using R’s rpart package, a hierarchical implantation model was created using the decision tree approach. The prognostic value of the model was assessed using ROC. III. RESULTS: 383 blastocysts from 368 FET cycles were examined in our study, of which 222 (57.9%) were implanted and 161 (42.1%) were not. Timing parameters of implanted embryos tended to be longer than that in the non-implanted group, and the division process of blastomeres was more synchronized, however not statistically. Embryos with direct cleavage had a significantly reduced implantation rate compared with non-direct groups (29.0% and 61.0%, p < 0.05) Analysis of morpho-kinetic parameters enabled us to develop a hierarchical model that places the direct cleavage, tPNa, and cc1 as the variables with the best prognosis of implantation. The AUC value of the model was 0.641. IV. CONCLUSION: The study showed that morpho-kinetic parameters at the early division stage have the predictive value of blastocyst implantation and can supplement traditional morphological assessment in embryo selection.https://www.worldscientific.com/doi/10.1142/S266131822374211X |
spellingShingle | Anh Phi Thi Tu Anh Vu Thi Mai Hop Vu Dinh Huong Nguyen Thi Lien #247 : Correlation Between the Embryo Morphokinetic Parameters Up To Cleavage Stage and Blastocyst Implantation Capability in Frozen Embryo Transfer Cycles Fertility & Reproduction |
title | #247 : Correlation Between the Embryo Morphokinetic Parameters Up To Cleavage Stage and Blastocyst Implantation Capability in Frozen Embryo Transfer Cycles |
title_full | #247 : Correlation Between the Embryo Morphokinetic Parameters Up To Cleavage Stage and Blastocyst Implantation Capability in Frozen Embryo Transfer Cycles |
title_fullStr | #247 : Correlation Between the Embryo Morphokinetic Parameters Up To Cleavage Stage and Blastocyst Implantation Capability in Frozen Embryo Transfer Cycles |
title_full_unstemmed | #247 : Correlation Between the Embryo Morphokinetic Parameters Up To Cleavage Stage and Blastocyst Implantation Capability in Frozen Embryo Transfer Cycles |
title_short | #247 : Correlation Between the Embryo Morphokinetic Parameters Up To Cleavage Stage and Blastocyst Implantation Capability in Frozen Embryo Transfer Cycles |
title_sort | 247 correlation between the embryo morphokinetic parameters up to cleavage stage and blastocyst implantation capability in frozen embryo transfer cycles |
url | https://www.worldscientific.com/doi/10.1142/S266131822374211X |
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