Precision stratification of prognostic risk factors associated with outcomes in gestational diabetes mellitus: a systematic review
Abstract Background The objective of this systematic review is to identify prognostic factors among women and their offspring affected by gestational diabetes mellitus (GDM), focusing on endpoints of cardiovascular disease (CVD) and type 2 diabetes (T2D) for women, and cardiometabolic profile for of...
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| Format: | Article |
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Nature Portfolio
2024-01-01
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| Series: | Communications Medicine |
| Online Access: | https://doi.org/10.1038/s43856-023-00427-1 |
| _version_ | 1797355592524759040 |
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| author | Zhila Semnani-Azad Romy Gaillard Alice E. Hughes Kristen E. Boyle Deirdre K. Tobias ADA/EASD PMDI Wei Perng |
| author_facet | Zhila Semnani-Azad Romy Gaillard Alice E. Hughes Kristen E. Boyle Deirdre K. Tobias ADA/EASD PMDI Wei Perng |
| author_sort | Zhila Semnani-Azad |
| collection | DOAJ |
| description | Abstract Background The objective of this systematic review is to identify prognostic factors among women and their offspring affected by gestational diabetes mellitus (GDM), focusing on endpoints of cardiovascular disease (CVD) and type 2 diabetes (T2D) for women, and cardiometabolic profile for offspring. Methods This review included studies published in English language from January 1st, 1990, through September 30th, 2021, that focused on the above outcomes of interest with respect to sociodemographic factors, lifestyle and behavioral characteristics, traditional clinical traits, and ‘omics biomarkers in the mothers and offspring during the perinatal/postpartum periods and across the lifecourse. Studies that did not report associations of prognostic factors with outcomes of interest among GDM-exposed women or children were excluded. Results Here, we identified 109 publications comprising 98 observational studies and 11 randomized-controlled trials. Findings indicate that GDM severity, maternal obesity, race/ethnicity, and unhealthy diet and physical activity levels predict T2D and CVD in women, and greater cardiometabolic risk in offspring. However, using the Diabetes Canada 2018 Clinical Practice Guidelines for studies, the level of evidence was low due to potential for confounding, reverse causation, and selection biases. Conclusions GDM pregnancies with greater severity, as well as those accompanied by maternal obesity, unhealthy diet, and low physical activity, as well as cases that occur among women who identify as racial/ethnic minorities are associated with worse cardiometabolic prognosis in mothers and offspring. However, given the low quality of evidence, prospective studies with detailed covariate data collection and high fidelity of follow-up are warranted. |
| first_indexed | 2024-03-08T14:13:21Z |
| format | Article |
| id | doaj.art-9f556ad8015a41bd976925532771ffc6 |
| institution | Directory Open Access Journal |
| issn | 2730-664X |
| language | English |
| last_indexed | 2024-03-08T14:13:21Z |
| publishDate | 2024-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Medicine |
| spelling | doaj.art-9f556ad8015a41bd976925532771ffc62024-01-14T12:34:14ZengNature PortfolioCommunications Medicine2730-664X2024-01-014111410.1038/s43856-023-00427-1Precision stratification of prognostic risk factors associated with outcomes in gestational diabetes mellitus: a systematic reviewZhila Semnani-Azad0Romy Gaillard1Alice E. Hughes2Kristen E. Boyle3Deirdre K. Tobias4ADA/EASD PMDIWei Perng5Department of Nutrition, Harvard T.H. Chan School of Public HealthDepartment of Pediatrics, Erasmus MC, University Medical CenterFaculty of Health and Life Sciences, University of Exeter Medical SchoolDepartment of Pediatrics and the Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical CampusDepartment of Nutrition, Harvard T.H. Chan School of Public HealthDepartment of Epidemiology and the Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical CampusAbstract Background The objective of this systematic review is to identify prognostic factors among women and their offspring affected by gestational diabetes mellitus (GDM), focusing on endpoints of cardiovascular disease (CVD) and type 2 diabetes (T2D) for women, and cardiometabolic profile for offspring. Methods This review included studies published in English language from January 1st, 1990, through September 30th, 2021, that focused on the above outcomes of interest with respect to sociodemographic factors, lifestyle and behavioral characteristics, traditional clinical traits, and ‘omics biomarkers in the mothers and offspring during the perinatal/postpartum periods and across the lifecourse. Studies that did not report associations of prognostic factors with outcomes of interest among GDM-exposed women or children were excluded. Results Here, we identified 109 publications comprising 98 observational studies and 11 randomized-controlled trials. Findings indicate that GDM severity, maternal obesity, race/ethnicity, and unhealthy diet and physical activity levels predict T2D and CVD in women, and greater cardiometabolic risk in offspring. However, using the Diabetes Canada 2018 Clinical Practice Guidelines for studies, the level of evidence was low due to potential for confounding, reverse causation, and selection biases. Conclusions GDM pregnancies with greater severity, as well as those accompanied by maternal obesity, unhealthy diet, and low physical activity, as well as cases that occur among women who identify as racial/ethnic minorities are associated with worse cardiometabolic prognosis in mothers and offspring. However, given the low quality of evidence, prospective studies with detailed covariate data collection and high fidelity of follow-up are warranted.https://doi.org/10.1038/s43856-023-00427-1 |
| spellingShingle | Zhila Semnani-Azad Romy Gaillard Alice E. Hughes Kristen E. Boyle Deirdre K. Tobias ADA/EASD PMDI Wei Perng Precision stratification of prognostic risk factors associated with outcomes in gestational diabetes mellitus: a systematic review Communications Medicine |
| title | Precision stratification of prognostic risk factors associated with outcomes in gestational diabetes mellitus: a systematic review |
| title_full | Precision stratification of prognostic risk factors associated with outcomes in gestational diabetes mellitus: a systematic review |
| title_fullStr | Precision stratification of prognostic risk factors associated with outcomes in gestational diabetes mellitus: a systematic review |
| title_full_unstemmed | Precision stratification of prognostic risk factors associated with outcomes in gestational diabetes mellitus: a systematic review |
| title_short | Precision stratification of prognostic risk factors associated with outcomes in gestational diabetes mellitus: a systematic review |
| title_sort | precision stratification of prognostic risk factors associated with outcomes in gestational diabetes mellitus a systematic review |
| url | https://doi.org/10.1038/s43856-023-00427-1 |
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